[1]窦 娜,刘筱茂,张 媛,等.胎宝汤治疗黄体功能不全型先兆流产疗效研究[J].陕西中医,2024,(9):1222-1225.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.016]
　DOU Na,LIU Xiaomao,ZHANG Yuan,et al.Efficacy of Taibao decoction on patients with luteal insufficiency type of threatened abortion[J].,2024,(9):1222-1225.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.016]
点击复制

胎宝汤治疗黄体功能不全型先兆流产疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1222-1225
栏目:
临床研究
出版日期:
2024-09-05

文章信息/Info

Title:
Efficacy of Taibao decoction on patients with luteal insufficiency type of threatened abortion
作者:
窦 娜; 刘筱茂; 张 媛; 霍艳宁; 李春春
(榆林市中医医院,陕西 榆林 719000)
Author(s):
DOU Na; LIU Xiaomao; ZHANG Yuan; HUO Yanning; LI Chunchun
(Yulin Traditional Chinese Medicine Hospital,Yulin 719000,China)
关键词:
先兆流产;  胎宝汤;  黄体功能不全;  孕酮;  血绒毛膜促性腺激素;  雌二醇
Keywords:
Threatened abortion;  Taibao decoction;  Luteal insufficiency;  Progesterone;  Blood chorionic gonadotropin;  Estradiol
分类号:
R 714.21
DOI:
DOI:10.3969/j.issn.1000-7369.2024.09.016
文献标志码:
A
摘要:
目的:探究胎宝汤对治疗黄体功能不全型先兆流产患者的应用价值。方法:选取黄体功能不全型先兆流产患者72例,采用信封随机抽取法分为对照组(n=36)和治疗组(n=36),对照组给予地屈孕酮治疗,治疗组给予胎宝汤联合地屈孕酮治疗。比较两组疗效、中医症状评分、症状缓解时间、血清同型半胱氨酸(Hcy)和内分泌激素水平[血绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E2)]及不良反应。结果:治疗组临床总有效率(97.22%)高于对照组(80.56%)(P<0.05); 治疗后治疗组中医症状评分低于对照组(P<0.05); 治疗组腹痛、腰酸消失时间、阴道止血时间及孕酮恢复时间均短于对照组(P<0.05); 治疗后两组Hcy均下降,且治疗组低于对照组; β-HCG、P及E2均上升,且治疗组高于对照组(均P<0.05); 对照组和观察组不良反应总发生率分别为16.67%和8.33%(P>0.05)。结论:胎宝汤治疗黄体功能不全型先兆流产疗效佳,可有效缓解临床症状,促进血清内分泌激素水平升高,Hcy水平降低,且安全性良好。
Abstract:
Objective:To explore the application value of Taibao decoction in the treatment of patients with luteal insufficiency type of threatened abortion.Methods:72 patients with luteal insufficiency type of threatened abortion were classified into control group(n=36)and treatment group(n=36)by adopting random envelope sampling method.The control group received dydrogesterone treatment,whereas the treatment group was treated with Taibao decoction combined with dydrogesterone.The efficacy,TCM symptoms scores,symptom relief time,serum homocysteine(Hcy)and endocrine hormones [blood chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E2)] and adverse reactions were compared.Results:The treatment group(97.22%)had total clinical effective rate than control group(80.56%)(P<0.05).The TCM symptoms scores were lower in treatment group after treatment(P<0.05).The abdominal pain relief time,disappearance time of waist soreness,vaginal hemostasis time and progesterone recovery time in treatment group were shorter compared with those in control group(P<0.05).After treatment,Hcy level was declined in both groups,and the Hcy level in treatment group was lower.The levels of β-HCG,P and E2 were enhanced,and the treatment group had higher levels(P<0.05).The total incidence rates of adverse reactions in control group and treatment group were 16.67% and 8.33%(P>0.05).Conclusion:Taibao decoction has good efficacy in the treatment of luteal insufficiency type of threatened abortion.In addition,it can effectively relieve the clinical symptoms,promote the increases of serum endocrine hormones,and reduce Hcy level,and it has good safety.

参考文献/References:

[1] 王建锋,贺青文,范秀芳,等.血清抗载脂蛋白A1抗体、抗C末端apoA-1抗体水平与先兆流产相关性研究[J].陕西医学杂志,2022,51(11):1368-1371.
[2] 李柯狄.经阴道彩色多普勒超声联合血清E2、β-HCG早期预测妊娠结局价值研究[J].陕西医学杂志,2020,49(6):732-735.
[3] 宋林科,程颢,张群青.彩色多普勒超声检查联合血清学指标检测在先兆流产诊断及预后评估中的价值分析[J].陕西医学杂志,2021,50(9):1086-1089.
[4] 陈俭勤,邓小中,姚周平.地屈孕酮片治疗黄体功能不全所致先兆流产疗效[J].中国计划生育学杂志,2022,30(12):2807-2811.
[5] 邓丽丽,邱翠华,孟玉会,等.滋肾安胎汤联合HCG、黄体酮治疗先兆流产疗效及对患者内分泌及免疫指标的影响[J].中国计划生育学杂志,2022,30(10):2208-2212.
[6] 谢幸,孔北华,段涛.妇产科学[M].9版.北京:人民卫生出版社,2018:70.
[7] 张杨,罗玉萍,成文俊.血清β-HCG、IL-6、ALP预测先兆性流产临床效果[J].中国计划生育学杂志,2023,31(4):894-897.
[8] 韩晗,张跃辉,韩亚鹏,等.从铁死亡角度探讨寿胎丸加味方对PCOS早期先兆流产患者的疗效机制[J].中医药学报,2023,51(10):67-71.
[9] 黄艳茜,邓高丕.邓高丕基于固冲通络辨治先兆流产合并宫腔积液经验[J].中医药导报,2023,29(10):173-176.
[10] 吴金兰,马岚,张丽.补肾安胎饮加减联合穴位贴敷治疗先兆流产疗效及对患者血清β-HCG、孕酮、雌二醇的影响[J].陕西中医,2021,42(9):1193-1196.
[11] 李雅静,孙光娟.固元稳胎汤联合地屈孕酮治疗先兆流产肾虚证效果及对子宫动脉血流、内分泌指标影响[J].中国计划生育学杂志,2023,31(10):2332-2337.
[12] 李艳青,赵方,吉萌萌,等.加味寿胎丸治疗先兆流产的疗效及对生殖免疫-内分泌功能的影响[J].时珍国医国药,2020,31(12):2971-2973.
[13] 方昉,徐晓栋,廖慧慧.中医妇科经典专著中中药治疗先兆流产用药规律的数据挖掘[J].广州中医药大学学报,2023,40(7):1832-1838.
[14] 顾姣,史琳茜.“加味补肾安胎饮”对肾虚型早期先兆流产患者性激素水平及免疫功能的影响——附46例临床资料[J].江苏中医药,2023,55(3):27-30.
[15] 尚鑫桐,黄楠,裘雅芬.中药汤剂辅助地屈孕酮治疗早期先兆流产的效果分析[J].中华全科医学,2021,19(7):1206-1209.
[16] 陈蔚,于田华,纪颖.益肾活血安胎方对多囊卵巢综合征胰岛素抵抗先兆流产肾虚血瘀证患者子宫动脉血流变化、糖代谢、血清β-人绒毛膜促性腺激素、抗心磷脂抗体的影响[J].河北中医,2020,42(10):1501-1507.
[17] 全向梅,吴桂云,蒋贤伟.超声监测黄体血流指数及外周血TPOAb、β-HCG水平对早期先兆流产预后临床意义[J].中国计划生育学杂志,2023,31(9):2134-2137.
[18] 翁兆银,季莉,钱春枝.辨证中药穴位贴敷辅助黄体酮治疗IVF-ET术后先兆流产的临床研究[J].川北医学院学报,2023,38(8):1130-1133.
[19] 林淑霞,陈锦红,徐慧娴,等.苎根合剂对高龄先兆流产患者滋养细胞增殖的影响[J].中国中西医结合杂志,2023,43(2):212-218.
[20] 林仲珊,姜小花,俞淑君,等.血Hcy水平对PCOS患者FET治疗流产风险的预测价值[J].安徽医科大学学报,2022,57(9):1503-1507.
[21] 赵婧含,李雪,吴文轩,等.熟地黄的化学成分及药理作用研究进展[J].中医药学报,2023,51(6):110-114.
[22] 陆启滨.陆启滨效方治验——固元升提汤[J].江苏中医药,2022,54(1):18-19.
[23] 张旻轶,楼毅云.滑胎安胎协定方促进滋养细胞迁移侵袭治疗复发性流产的作用机制研究[J].浙江医学,2023,45(14):1486-1491.
[24] 黄明珠,王景龙,崔晓萍,等.菟丝子的药理作用研究进展[J].安徽中医药大学学报,2023,42(5):101-104.
[25] 奚嘉.奚嘉效方治验——助孕益膜汤[J].江苏中医药,2022,54(8):5-6.

相似文献/References:

[1]吴金兰,马 岚,张 丽.补肾安胎饮加减联合穴位贴敷治疗先兆流产疗效及对患者血清β-HCG、孕酮、雌二醇的影响[J].陕西中医,2021,(9):1193.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.010]
　WU Jinlan,MA Lan,ZHANG Li.Clinical effect of modified Bushen Antai decoction combined with acupoint application in threatened abortion and influence on serum β-HCG,progesterone and estradiol[J].,2021,(9):1193.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.010]
[2]朱俊楠,霍 艳,高 帅,等.从“肝肾同源”论治先兆流产[J].陕西中医,2023,(5):612.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.016]
　ZHU Junnan,HUO Yan,GAO Shuai,et al.Discussion of treating threatened abortion based on “homogeny of liver and kidney” theory[J].,2023,(9):612.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.016]

备注/Memo

备注/Memo:
基金项目:陕西省中医药管理局委托课题(SZY-NLTL-2022-027)
更新日期/Last Update: 2024-09-09