[1]黄玉迎,杨培伟,王晓杰,等.基于土壅木郁理论探讨铁死亡与代谢相关脂肪性肝病的关系[J].陕西中医,2024,(10):1395-1398.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.022]
　HUANG Yuying,YANG Peiwei,WANG Xiaojie,et al.Exploration on relationship between ferroptosis and metabolism-associated fatty liver disease based on earth stagnation and wood depression[J].,2024,(10):1395-1398.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.022]
点击复制

基于土壅木郁理论探讨铁死亡与代谢相关脂肪性肝病的关系
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年10期
页码:
1395-1398
栏目:
学术探讨
出版日期:
2024-10-05

文章信息/Info

Title:
Exploration on relationship between ferroptosis and metabolism-associated fatty liver disease based on earth stagnation and wood depression
作者:
黄玉迎1; 杨培伟2; 王晓杰1; 刘镇亚1; 赵文霞2
(1.河南中医药大学第一临床医学院,河南 郑州 450000; 2.河南中医药大学第一附属医院脾胃肝胆科,河南 郑州 450000)
Author(s):
HUANG Yuying; YANG Peiwei; WANG Xiaojie; LIU Zhenya; ZHAO Wenxia
(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,China)
关键词:
土壅木郁;  铁死亡;  代谢相关脂肪性肝病;  非酒精性脂肪性肝病;  健脾疏肝;  铁代谢
Keywords:
Earth stagnation and wood depression;  Ferroptosis;  Metabolic-associated fatty liver disease;  Non-alcoholic fatty liver disease;  Soothing liver and invigorating spleen;  Iron metabolism
分类号:
R 575.5
DOI:
DOI:10.3969/j.issn.1000-7369.2024.10.022
文献标志码:
A
摘要:
代谢相关脂肪性肝病(MAFLD)作为一种常见肝病,发病机制复杂,但多与机体代谢障碍有关,如高脂血症、肥胖、胰岛素抵抗等。脾的运化功能与机体代谢的关系已被多次证实,中医学也认为MAFLD虽病位在肝,但与脾密切相关。现代研究发现以铁代谢紊乱为基础的铁死亡在MAFLD向炎症、纤维化进展中起到重要作用。本文基于传统医学的土壅木郁理论,从铁死亡发生过程中铁代谢及脂质过氧化物聚集机制分析中医学的肝与脾在MAFLD发生发展中的作用,提出健脾疏肝可通过抑制铁死亡从而起到防治MAFLD作用的新途径。
Abstract:
As a common liver disease,Metabolic-associated fatty liver disease(MAFLD)has a complex pathogenesis but is mostly associated with metabolic disorders,such as hyperlipidemia,obesity,and insulin resistance.The relationship between the transport function of the spleen and body metabolism has been confirmed many times.Traditional Chinese medicine also believes that MAFLD is closely related to the spleen,although it is located in the liver.Modern studies have found that ferroptosis based on iron metabolism disorders plays an important role in the progression of MAFLD to inflammation and fibrosis.Based on the theory of “earth stagnation and wood depression”,in this paper,the role of liver and spleen in traditional Chinese medicine in the occurrence and development of MAFLD was analyzed from the mechanism of iron metabolism and lipid peroxide aggregation during the occurrence of ferroptosis,and also proposed a new way to soothing liver and invigorating spleen to prevent and treat MAFLD by inhibiting ferroptosis.

参考文献/References:

[1] XIAO J,WANG F,WONG N K,et al.Global liver disease burdens and research trends:Analysis from a Chinese perspective[J].J Hepatol,2019,71(1):212-221.
[2] MAHER J J,SCHATTENBERG J M.Nonalcoholic latty liver disease in 2020[J].Gastroenterology,2020,158(7):1849-1850.
[3] PAFILI K,RODEN M.Nonalcoholic fatty liver disease(NAFLD)from pathogenesis to treatment concepts in humans[J].Mol Metab,2021,50:101122.
[4] YOUNOSSI Z,ANSTEE Q M,MARIETTI M,et al.Global burden of NAFLD and NASH:Trends,predictions,risk factors and prevention[J].Nat Rev Gastroenterol Hepatol,2018,15(1):11-20.
[5] ESLAM M,SANYAL A J,GEORGE J.MAFLD:A consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J].Gastroenterology,2020,158(7):1999-2014.
[6] GAUTHERON J,GORES G J,RODRIGUES C M.Lytic cell death in metabolic liver disease[J].J Hepatol,2020,73(2):394-408.
[7] 刘頔,纪立金.浅谈“土壅木郁”理论与临床运用[J].中华中医药杂志,2021,36(4):1956-1958.
[8] 黄祖鸿,石清兰,柏文婕,等.毛德文教授运用“调肝理脾”法治疗慢性肝病经验总结[J].陕西中医,2021,42(8):1112-1114,1119.
[9] KHAN R S,BRIL F,CUSI K,et al.Modulation of insulin resistance in nonalcoholic fatty liver disease[J].Hepatology,2019,70(2):711-724.
[10] CHEN Z,TIAN R,SHE Z,et al.Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease[J].Free Radic Biol Med,2020,152:116-141.
[11] 延华,柴春艳,张丹,等.基于JNK信号通路探讨自噬、胰岛素抵抗在非酒精性脂肪性肝病中的发病机制[J].陕西医学杂志,2023,52(11):1506-1510.
[12] SCHWABE R F,LUEDDE T.Apoptosis and necroptosis in the liver:a matter of life and death[J].Nat Rev Gastroenterol Hepatol,2018,15(12):738-752.
[13] WU S,YANG J,SUN G,et al.Macrophage extracellular traps aggravate iron overload-related liver ischaemia/reperfusion injury[J].Br J Pharmacol,2021,178(18):3783-3796.
[14] 刘应莉,王艳荣,张秋瓒.肠道菌群-过氧化物酶体增殖物激活受体信号通路及其在代谢相关脂肪性肝病发病中的作用研究进展[J].陕西医学杂志,2021,50(9):1166-1169.
[15] QI J,KIM J W,ZHOU Z,et al.Ferroptosis affects the progression of nonalcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice[J].Am J Pathol,2020,190(1):68-81.
[16] STOCKWELL B R.Ferroptosis turns 10:Emerging mechanisms,physiological functions,and therapeutic applications[J].Cell,2022,185(14):2401-2421.
[17] ZHENG J,CONRAD M.The metabolic underpinnings of ferroptosis[J].Cell Metab,2020,32(6):920-937.
[18] 孙静文,孙铭良,袁静云,等.基于“土壅木郁”探析非酒精性脂肪肝的痰湿体质分布研究[J].中华中医药杂志,2020,35(2):956-958.
[19] 金伶,龙兴江,袁大华,等.重度β-地中海贫血患儿脾脏切除术前后铁负荷的变化[J].临床儿科杂志,2014,32(4):343-345.
[20] CHENG R,DHORAJIA V V,KIM J,et al.Mitochondrial iron metabolism and neurodegenerative diseases[J].Neurotoxicology,2022,88:88-101.
[21] WANG C Y,BABITT J L.Liver iron sensing and body iron homeostasis[J].Blood,2019,133(1):18-29.
[22] ALTAMURA S,MUDDER K,SCHLOTTERER A,et al.Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload[J].Mol Metab,2021,51:101235.
[23] HIRSCHHORN T,STOCKWELL B R.The development of the concept of ferroptosis[J].Free Radic Biol Med,2019,133:130-143.
[24] JIANG X,STOCKWELL B R,CONRAD M.Ferroptosis:Mechanisms,biology and role in disease[J].Nat Rev Mol Cell Biol,2021,22(4):266-282.
[25] LI J,CAO F,YIN H L,et al.Ferroptosis:past,present and future[J].Cell Death Dis,2020,11(2):88.
[26] 李莎,寇少杰,薛敬东.薛敬东运用“浊毒理论”治疗非酒精性脂肪肝经验总结[J].陕西中医,2021,42(3):363-365.

相似文献/References:

[1]陈抒鹏,王思梦,唐娜娜,等.基于浊邪与铁死亡相关性探析动脉粥样硬化之病机[J].陕西中医,2022,(11):1589.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.023]
　CHEN Shupeng,WANG Simeng,TANG Nana,et al.Exploring the pathogenesis of atherosclerosis based on the correlation between turbid pathogens and ferroptosis[J].,2022,(10):1589.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.023]
[2]胡哲君,汤穆浛,张 锐,等.基于“肝病实脾”理论探讨逍遥散对肝纤维化大鼠肝星状细胞铁死亡的影响[J].陕西中医,2024,(2):159.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.003]
　HU Zhejun,TANG Muhan,ZHANG Rui,et al.Effect of Xiaoyao powder on ferroptosis of hepatic stellate cells in rats with liver fibrosis based on the theory of “treating liver by nourishing spleen”[J].,2024,(10):159.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.003]
[3]郭桓博,马瑞雪,朱正望,等.中药基于铁死亡机制防治肝癌研究进展[J].陕西中医,2024,(2):282.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.030]
　GUO Huanbo,MA Ruixue,ZHU Zhengwang,et al.Research progress in the prevention and treatment of liver cancer based on the mechanism of iron osis in traditional Chinese medicine[J].,2024,(10):282.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.030]
[4]李忠泽,李嘉玮,白春晓,等.补中益气汤加减治疗气血亏虚型腰椎间盘突出症疗效及对患者疼痛程度的影响研究[J].陕西中医,2024,(10):1340.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.009]
　LI Zhongze,LI Jiawei,BAI Chunxiao,et al.Effects of modified Buzhong Yiqi decoction on score of pain degree in LDH of qi-blood deficiency syndrome[J].,2024,(10):1340.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.009]
[5]廖飞飞,杨文文,路爱梅,等.麝香通心滴丸调控HIF-1α/HO-1通路抑制铁死亡缓解心肌缺血再灌注损伤研究[J].陕西中医,2025,46(2):147.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.001]
　LIAO Feifei,YANG Wenwen,LU Aimei,et al.Shexiang Tongxin dripping pills alleviate myocardial ischemia-reperfusion injury through inhibition of ferroptosis via regulation of the HIF-1α/HO-1 signaling pathway[J].,2025,46(10):147.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.001]
[6]张明蕊,范焕芳,陈佳琪,等.中医药调控铁死亡治疗非小细胞肺癌研究进展[J].陕西中医,2025,46(4):572.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.030]
　ZHANG Mingrui,FAN Huanfang,CHEN Jiaqi,et al.Research progress of Chinese medicine regulating iron death in treatment of non-small cell lung cancer[J].,2025,46(10):572.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.030]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(81473651); 河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020024)
更新日期/Last Update: 2024-10-08