[1]唐晨思,向广生,张翠娜,等.健脾益肾通络汤对IgA肾病患者肾功能、炎症因子的影响[J].陕西中医,2024,(11):1499-1503.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.012]
　TANG Chensi,XIANG Guangsheng,ZHANG Cuina,et al.Impact of Jianpi Yishen Tongluo decoction on renal function and inflammatory factors in patients with IgA nephropathy[J].,2024,(11):1499-1503.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.012]
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健脾益肾通络汤对IgA肾病患者肾功能、炎症因子的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1499-1503
栏目:
临床研究
出版日期:
2024-11-05

文章信息/Info

Title:
Impact of Jianpi Yishen Tongluo decoction on renal function and inflammatory factors in patients with IgA nephropathy
作者:
唐晨思; 向广生; 张翠娜; 赵晶晶; 路博宇
(石家庄市中医院,河北 石家庄 050031)
Author(s):
TANG Chensi; XIANG Guangsheng; ZHANG Cuina; ZHAO Jingjing; LU Boyu
(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050031,China)
关键词:
IgA肾病;  健脾益肾通络汤;  中医证候积分;  肾功能;  炎症因子;  不良反应
Keywords:
IgA nephropathy;  Jianpi Yishen Tongluo decoction;  Traditional Chinese medicine syndrome points;  Renal function;  Inflammatory factors;  Untoward effect
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2024.11.012
文献标志码:
A
摘要:
目的:探究健脾益肾通络汤治疗IgA肾病效果及对患者肾功能、炎症因子的影响。方法:选取IgA肾病患者98例,采用随机掷硬币法分为两组。西药组常规西药治疗,49例,联合组在西药组的基础上服用健脾益肾通络汤,49例。治疗3个月后比较两组疗效、中医证候积分、肾功能[24 h尿蛋白定量(24 h UTP)、血清血肌酐(SCr)、血尿素氮(BUN)、白蛋白(ALB)]、炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、干扰素-γ(INF-γ)]和不良反应。结果:治疗总有效率联合组为95.92%,高于西药组的81.63%(P<0.05)。治疗后两组的中医证候积分、24 h UTP及血清SCr、BUN、IL-6、TNF-α均降低,且联合组均低于西药组,差异有统计学意义(均P<0.05)。治疗后,两组患者血清ALB、INF-γ均升高,且联合组高于西药组,差异有统计学意义(均P<0.05)。不良反应总发生率西药组为10.20%,联合组为14.29%,两组比较差异无统计学意义(P>0.05)。结论:健脾益肾通络汤治疗IgA肾病疗效较好,可以有效减轻患者临床症状,改善肾功能,降低炎症反应,安全性较高。
Abstract:
Objective:To explore effect of Jianpi Yishen Tongluo decoction in treatment of IgA nephropathy and its influence on renal function and inflammatory factors.Methods:98 patients with IgA nephropathy were divided into western medicine group(conventional western medicine treatment,49 cases)and joint group(Jianpi Yishen Tongluo decoction on the basis of western medicine group,49 cases)by random coin tossing method.After 3 months of treatment,efficacy,TCM syndromes scores,renal function [24 h urinary total protein(24 h UTP),serum creatinine(SCr),blood urea nitrogen(BUN),albumin(ALB)],inflammatory factors [tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(INF-γ)] and adverse reactions were compared.Results:The total response rate was 95.92%,which was higher than 81.63% in the western medicine group(P<0.05).After treatment,the TCM syndromes scores and levels of 24 h UTP and serum SCr,BUN,TNF-α and IL-6 in the two groups were decreased,and the scores and levels in joint group were lower than those in western medicine group,difference statistically significant(all P<0.05).The levels of serum ALB and INF-γ were increased in both groups after treatment,and the levels were higher in joint group than those in western medicine group,difference statistically significant(all P<0.05).The total incidence of adverse reactions was 10.20% in the western medicine group and 14.29% in the combined group,with no significant difference between the two groups(P>0.05).Conclusion:Jianpi Yishen Tongluo decoction has significant efficacy in the treatment of IgA nephropathy,and can effectively relieve clinical symptoms,improve renal functionand reduce inflammatory response,with high safety.

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备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研计划项目(2019407)
更新日期/Last Update: 2024-11-11