[1]杨丰贤,张 静,陈风彩.益肾活络汤联合二甲双胍治疗老年2型糖尿病疗效研究[J].陕西中医,2024,(11):1504-1507.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.013]
　YANG Fengxian,ZHANG Jing,CHEN Fengcai.Effect of Yishen Huoluo decoction combined with metformin on efficacy in elderly patients with T2DM[J].,2024,(11):1504-1507.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.013]
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益肾活络汤联合二甲双胍治疗老年2型糖尿病疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1504-1507
栏目:
临床研究
出版日期:
2024-11-05

文章信息/Info

Title:
Effect of Yishen Huoluo decoction combined with metformin on efficacy in elderly patients with T2DM
作者:
杨丰贤; 张 静; 陈风彩
(青岛大学附属青岛市海慈医院 青岛市中医医院,山东 青岛 266033)
Author(s):
YANG Fengxian; ZHANG Jing; CHEN Fengcai
(Qingdao Hiser Hospital Affiliated of Qingdao University,Qingdao Traditional Chinese Medicine Hospital,Qingdao 266033,China)
关键词:
2型糖尿病;  益肾活络汤;  二甲双胍;  胰岛素抵抗;  糖代谢;  血清视黄醇结合蛋白-4
Keywords:
Type 2 diabetes mellitus;  Yishen Huoluo decoction;  Metformin;  Insulin resistance;  Glucose metabolism;  Serum retinol-binding protein-4
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7369.2024.11.013
文献标志码:
A
摘要:
目的:探究益肾活络汤联合二甲双胍对老年2型糖尿病(T2DM)患者血糖、胰岛素抵抗的影响。方法:选取104例老年T2DM患者,按照随机数字表法分为西药组(n=52)和联合组(n=52),所有患者均给予常规治疗,西药组给予二甲双胍治疗,联合组在西药组基础上予以益肾活络汤治疗。比较两组患者临床疗效、中医症状积分,治疗前后糖代谢、胰岛素抵抗指数(IR)、体重指数(BMI)、血清视黄醇结合蛋白-4(RBP-4)、血清胱抑素C(CYS-C)、同型半胱氨酸(HCY)及不良反应。结果:联合组治疗总有效率90.38% 高于西药组的76.92%,差异有统计学意义(P<0.05)。治疗后两组患者咽干舌燥、倦怠无力、多饮、多食、气短、五心烦热评分均下降,且治疗后联合组症状评分低于西药组,差异有统计学意义(均P<0.05)。治疗后,两组患者糖代谢相关指标、HOMA-IR、BMI、RBP-4、CYS-C、HCY下降,且联合组低于西药组,差异有统计学意义(均P<0.05)。西药组中1例轻度低血糖、1例消化不良,联合组1例轻度低血糖、2例胃肠道不适,两组不良反应发生率比较,差异无统计学意义(χ2=0.210,P=0.647)。结论:益肾活络汤联合二甲双胍可改善老年T2DM患者临床症状,稳定其糖代谢,延缓T2DM及其并发症进展。
Abstract:
Objective:To investigate influence of Yishen Huoluo decoction combined with metformin on blood glucose and insulin resistance in elderly patients with type 2 diabetes mellitus(T2DM).Methods:104 elderly patients with T2DM were selected.According to the random number table method,they were divided into western medication group(n=52)and combination group(n=52).All patients were given conventional treatment,the western medication group were treated with metformin,and the combination group treated with Yishen Huoluo decoction on the basis of the western medication group.Clinical efficacy,TCM symptoms scores,glucose metabolism,insulin resistance index(IR),body mass index(BMI),serum RBP-4,CYS-C and HCY before and after treatment and adverse reactions were compared.Results:The total effective rate of treatment in the combined group 90.38% was higher than that in the western medication group 76.92%,difference statistically significant(P<0.05).After treatment,the scores of dry mouth,fatigue,dry mouth and polydipsia,hunger,shortness of breath and lazy speech,five irritable heat in the two groups were decreased,and the symptoms scores were lower in the combined group,difference statistically significant(all P<0.05).The glucose metabolism,HOMA-IR,BMI,RBP-4,CYS-C and HCY were reduced in both groups after treatment,and the above indicators in the combined group after treatment were lower than those in the western medication group,difference statistically significant(all P<0.05).There were one case of mild hypoglycemia,one case of dyspepsia in the western medication group,and one case of mild hypoglycemia,two cases of gastrointestinal discomfort in the combination group,difference not statistically significant(χ2=0.210,P=0.647).Conclusion:Combination of Yishen Huoluo decoction and metformin can improve clinical symptoms,stabilize glucose metabolism,and delay the progression of T2DM and its complications in elderly patients with T2DM.

参考文献/References:

[1] LI Y,TENG D,SHI X,et al.Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American diabetes association:National cross sectional study[J].BMJ,2020,369:997-1008.
[2] 陆伟江,杨虹,蒙晓宇,等.广西成年居民糖尿病患病率和知晓、治疗及控制情况调查[J].中国慢性病预防与控制,2018,26(4):250-253,261.
[3] 冯祥,冯学强,边迎光,等.扬中市中老年居民糖尿病患病率、知晓率、治疗率和控制率现状及其与社会经济地位关系[J].中国公共卫生,2021,37(6):960-964.
[4] 李婷,苏虹霞,段玉红,等.中医辨证联合辅助干预治疗2型糖尿病疗效研究[J].陕西中医,2022,43(12):1725-1728.
[5] 夏城东.2型糖尿病中医药治疗的脏腑归属[J].中国中西医结合杂志,2021,41(6):748-751.
[6] 邓小敏,陈思华,陈兰,等.基于《黄帝内经》理论应用“填培五脏”法治疗2型糖尿病初探[J].中国中医基础医学杂志,2019,25(5):683-684.
[7] 姜德友,王佳柔,王远红.龙江医派杰出医家华廷芳治疗消渴经验[J].中华中医药杂志,2020,35(3):1097-1099.
[8] 王梦迪,董超,庞彦余,等.益肾通络法改善糖尿病肾脏疾病患者肾脏结局的临床疗效分析[J].中华中医药杂志,2023,38(8):3980-3985.
[9] 钱冬梅,陶小琴,丁仁华,等.参芪地黄汤加减治疗糖尿病气阴两虚证疗效及对患者炎症指标与免疫功能的影响[J].陕西中医,2022,43(4):469-471.
[10] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315-409.
[11] 中华人民共和国卫生部.中药新药临床研究指导原则试行[M].北京:中国医药科技出版社,2002:233-238.
[12] 张伯礼,吴勉华,林子强,等.中医内科学[M].北京:中国中医药出版社,2019:469-475.
[13] 王艳梅,张久亮.基于《黄帝内经》对谷物精微转化的阐述探究糖尿病的病机[J].中华中医药杂志,2021,36(12):6963-6966.
[14] 周静鑫,鲁轶臻,杨杰,等.从“兰除陈气”探析肥胖辨治[J].中国实验方剂学杂志,2023,29(16):72-78.
[15] 杨化冰,邹小娟.“阳道实,阴道虚”的涵义与糖尿病病机[J].中医杂志,2018,59(13):1115-1117.
[16] 徐惠娟,戴加乐,杨金芬,等.六味地黄丸联合二甲双胍片治疗2型糖尿病疗效观察[J].中华中医药学刊,2019,37(7):1747-1750.
[17] 纪利梅,刘宝利,李仁武,等.温阳益肾汤联合磷酸西格列汀治疗糖尿病肾病的临床效果[J].辽宁中医杂志,2021,48(5):112-116.
[18] 于洋,赵宁,张娜.六味地黄丸对糖尿病大鼠血管功能的影响及抗氧化应激机制[J].中国老年学杂志,2018,38(11):2712-2715.
[19] 郭航,赵春燕,战丽彬,等.基于网络药理学的六味地黄丸治疗高血压、2型糖尿病、阿尔茨海默病的异病同治机制分析[J].中药药理与临床,2021,37(1):41-49.
[20] 毕境新,张秋娥,丁雷,等.天花粉-黄精药对对糖尿病小鼠糖脂代谢及肝脏胰岛素抵抗的影响[J].中国实验方剂学杂志,2022,28(21):42-49.
[21] 袁丽,宁磊,白亚菲,等.桑枝总生物碱联合高压氧治疗对老年2型糖尿病患者HOMA-IR及HOMA-β等指标的改善作用[J].中国老年学杂志,2023,43(23):5652-5655.
[22] 汪琳姣,王德琴,周永华,等.糖尿病视网膜病变患者血清视黄醇结合蛋白4及胱抑素C水平的变化及意义研究[J].中国全科医学,2018,21(5):517-520,525.
[23] 喻昆林,虞青,袁昌丽.2型糖尿病患者血清胱抑素C、25羟维生素D和同型半胱氨酸与下肢血管病变的相关性[J].中国老年学杂志,2020,40(5):936-939.
[24] 王萍,王文娟,杜翔.慢性肾脏病患者肾素-血管紧张素系统与血浆β-淀粉样蛋白相关性研究[J].陕西医学杂志,2022,51(5):574-577,590.

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备注/Memo

备注/Memo:
基金项目:山东省中医药科技项目(2020Q115)
更新日期/Last Update: 2024-11-11