[1]李飞亚,颜思阳,李 中,等.基于阴阳学说探讨小胶质细胞极化在缺血性卒中神经炎症治疗中的应用[J].陕西中医,2024,(11):1521-1524,1537.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.017]
　LI Feiya,YAN Siyang,LI Zhong,et al.Investigate application of microglial polarization in treatment of neuroinflammation in ischemic stroke based on theory of Yin and Yang[J].,2024,(11):1521-1524,1537.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.017]
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基于阴阳学说探讨小胶质细胞极化在缺血性卒中神经炎症治疗中的应用
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1521-1524,1537
栏目:
学术探讨
出版日期:
2024-11-05

文章信息/Info

Title:
Investigate application of microglial polarization in treatment of neuroinflammation in ischemic stroke based on theory of Yin and Yang
作者:
李飞亚; 颜思阳; 李 中; 何孟豪; 周德生; 马 强; 刘利娟
(湖南中医药大学第一附属医院,湖南 长沙 410007)
Author(s):
LI Feiya; YAN Siyang; LI Zhong; HE Menghao; ZHOU Desheng; MA Qiang; LIU Lijuan
(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
关键词:
缺血性卒中;  阴阳学说;  小胶质细胞;  神经炎症;  阴平阳秘
Keywords:
Ischemic stroke;  Theory of Yin and Yang;  Microglia;  Neuroinflammation;  Relative equilibrium of Yinyang
分类号:
R 255.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.11.017
文献标志码:
A
摘要:
缺血性卒中(IS)在中医属于“中风”范畴,其核心病机为脏腑阴阳失调、气血逆乱。小胶质细胞极化及其介导的神经炎症贯穿IS整个病理过程,是IS的关键病理机制。M1/M2型小胶质细胞比例失衡是IS后炎症反应过度、神经损伤加剧的重要原因。小胶质细胞极化与中医阴阳学说的“对立制约”“相互转化”等相契合。本研究将小胶质细胞极化与阴阳学说联系,探讨在阴阳学说指导下中医药调控小胶质细胞极化治疗IS,为阴阳学说的微观化、现代化以及IS的中医药防治提供参考。
Abstract:
Ischemic stroke belongs to category of stroke in traditional Chinese medicine.Its core mechanism was imbalance of Yin and Yang and rebellion of Qi and blood.Microglia polarization and neuroinflammation run through the whole pathological process of ischemic stroke,which was the key pathological mechanism of ischemic stroke.The imbalance of M1-type microglia and M2-type microglia was an important cause of excessive inflammation and aggravated nerve injury after ischemic stroke.Meanwhile,microglia polarization was compatible connotation of Yin and Yang opposition,inter-transformation in theory of Yin and Yang.Accordingly,this paper links microglia polarization with the theory of Yin and Yang,explores the use of traditional Chinese medicine to regulate microglia polarization under guidance of Yin and Yang theory for the treatment of ischemic stroke,in order to provide reference for the microcosm and modernization of the theory of Yinyang and the treatment of ischemic stroke by traditional Chinese medicine.

参考文献/References:

[1] KISA A,GBD stroke collaborators global regional and national burden of stroke and its risk factors 1990-2019:A systematic analysis for the global burden of disease study 2019[J].Lancet Neurol,2021,20(10):795-820.
[2] ZHOU M,WANG H,ZENG X,et al.Mortality morbidity and risk factors in China and its provinces 1990-2017:A systematic analysis for the global burden of disease study 2017[J].Lancet,2019,394(10204):1145-1158.
[3] WU S,WU B,LIU M,et al.Stroke in China:Advances and challenges in epidemiology prevention and management[J].Lancet Neurol,2019,18(4):394-405.
[4] PRZYKAZA L.Understanding the connection between common stroke comorbidities their associated inflammation and the course of the cerebral Ischemia/Reperfusion cascade[J].Front Immunol,2021,12(1):782569.
[5] JURCAU A,SIMION A.Neuroinflammation in cerebral ischemia and Ischemia/Reperfusion injuries:From pathophysiology to therapeutic strategies[J].Int J Mol Sci,2021,23(1):14.
[6] PLANAS A M.Role of microglia in stroke[J].Glia,2024,72(6):1016-1053.
[7] 孙广仁.中医基础理论[M].北京:中国中医药出版社,2002:34.
[8] 张宇鹏.中医阴阳学说探析[J].中国中医基础医学杂志,2022,28(1):9-12.
[9] 迟显苏,梁晓,魏竞竞,等.基于血浊理论从痰、瘀、毒论治缺血性脑卒中[J].陕西中医,2023,44(7):917-921.
[10] LU W,CHEN Z,WEN J.Flavonoids and ischemic stroke-induced neuroinflammation:Focus on the glial cells[J].Biomed Pharmacother,2024,170:115847.
[11] QIN C,ZHOU L Q,MA X T,et al.Dual functions of microglia in ischemic stroke[J].Neurosci Bull,2019,35(5):921-933.
[12] YAN X,YANG K,XIAO Q,et al.Central role of microglia in sepsis-associated encephalopathy:From mechanism to therapy[J].Front Immunol,2022,13:929316.
[13] 赵小云,李心仪,周春祥.苓桂术甘汤抑制脂多糖诱导小胶质细胞由M2向M1型极化作用机制[J].陕西中医,2023,44(11):1503-1508.
[14] VIDALI A,RADFORD R,ARAMIDEH J A,et al.Microglia morphophysiological diversity and its implications for the CNS[J].Front Immunol,2022,13:997786.
[15] WANG H,LI J,ZHANG H,et al.Regulation of microglia polarization after cerebral ischemia[J].Front Cell Neurosci,2023,17:1182621.
[16] 张霞婧,毛肖肖,朱芳芸,等.丙酮酸乙酯通过调控小胶质细胞极化减轻脑缺血再灌注损伤实验研究[J].陕西医学杂志,2022,51(5):520-524.
[17] LONG Y,LI X Q,DENG J,et al.Modulating the polarization phenotype of microglia:A valuable strategy for central nervous system diseases[J].Ageing Res Rev,2024,93:102160.
[18] LIU R,LIAO X Y,PAN M X,et al.Glycine exhibits neuroprotective effects in ischemic stroke in rats through the inhibition of M1 microglial polarization via the NF-κB p65/Hif-1α signaling pathway[J].J Immunol,2019,202(6):1704-1714.
[19] ZHOU X,ZHAO R,LV M,et al.ACSL4 promotes microglia-mediated neuroinflammation by regulating lipid metabolism and VGLL4 expression[J].Brain Behav Immun,2023,109:331-343.
[20] SHI K,TIAN D C,LI Z G,et al.Global brain inflammation in stroke[J].Lancet Neurol,2019,18(11):1058-1066.
[21] ALSBROOK D L,NAPOLI M,BHATIA K,et al.Neuroinflammation in acute ischemic and hemorrhagic stroke[J].Curr Neurol Neurosci Rep,2023,23(8):407-431.
[22] ZHANG W,TIAN T,GONG S X,et al.Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke[J].Neural Regen Res,2021,16(1):6-11.
[23] MA Y,WANG J,WANG Y,et al.The biphasic function of microglia in ischemic stroke[J].Prog Neurobiol,2017,157:247-272.
[24] WANG Y,LEAK R K,CAO G.Microglia-mediated neuroinflammation and neuroplasticity after stroke[J].Front Cell Neurosci,2022,16:980722.
[25] XUE Y,NIE D,WANG L J,et al.Microglial polarization:Novel therapeutic strategy against ischemic stroke[J].Aging Dis,2021,12(2):466-479.
[26] 张春海,闫坤,周建昌,等.基于缺血半暗带为基础探究急性脑梗死溶栓治疗预后不良发生的危险因素及预测模型构建[J].陕西医学杂志,2024,53(2):217-220,225.
[27] KAESMACHER J,MEINEL T R,KURMANN C,et al.Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy:A systematic review and meta-analysis of observational data[J].J Neurointerv Surg,2021,13(12):1073-1080.
[28] YOU S,MA Z,ZHANG P,et al.Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia[J].Biomed Pharmacother,2024,174:116460.
[29] TANG H,WU L,CHEN X,et al.Paeoniflorin improves functional recovery through repressing neuroinflammation and facilitating neurogenesis in rat stroke model[J].PeerJ,2021,9:e10921.
[30] 唐冰雪,张源文,吴雅晨,等.淫羊藿苷对脑缺血再灌注大鼠的神经保护及小胶质细胞TLR4/NF-κB通路的影响[J].中国实验方剂学杂志,2020,26(22):47-52.
[31] 程伟能,南丽红,张玉琴,等.瓜蒌桂枝汤对脑缺血/再灌注损伤大鼠小胶质细胞极化的影响[J].福建中医药,2021,52(4):16-19.
[32] 刘吉勇,张文丽,廖君,等.脑泰方对脑缺血再灌注损伤小胶质细胞极化及胶质瘢痕的影响[J].中国中药杂志,2024,49(4):989-999.
[33] 彭晓云,袁博,田甜,等.电头针对缺血性脑卒中大鼠缺血皮质区炎性反应及小胶质细胞极化的影响[J].中国针灸,2023,43(9):1050-1055.
[34] 焦冰清,骆建宇,姚露露,等.电针预处理对缺血性中风小鼠早期小胶质细胞及血清炎性因子的影响[J].针刺研究,2023,48(12):1227-1235.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82104766); 湖南省自然科学基金资助项目(2024JJ5313,2024JJ6358); 湖南省级财政中医药项目名院工程院内优势病种项目[RSK-010-13(006-09)]; 长沙市自然科学基金资助项目(KQ2208202); 湖南中医药大学校级科研基金资助项目(2022XYLH016)
更新日期/Last Update: 2024-11-11