[1]田梦萱,宁 博,赵明君,等.从脑源性神经营养因子探讨冠心病合并焦虑抑郁中医治疗机制[J].陕西中医,2024,(11):1533-1537.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.020]
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从脑源性神经营养因子探讨冠心病合并焦虑抑郁中医治疗机制
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1533-1537
栏目:
长安医学
出版日期:
2024-11-05

文章信息/Info

作者:
田梦萱1宁 博2赵明君2王 松1范新发3谭绍坤3宋红莉3
(1.河北中医药大学研究生学院,河北 石家庄 050091; 2.陕西中医药大学附属医院,陕西 咸阳 712021; 3.保定市第一中医院,河北 保定 071000)
关键词:
冠心病合并焦虑抑郁 脑源性神经营养因子 中医药 炎症反应 氧化应激 信号通路
分类号:
R 541.9
DOI:
DOI:10.3969/j.issn.1000-7369.2024.11.020
文献标志码:
A
摘要:
冠心病(CHD)发病率及病死率逐年攀升,焦虑抑郁是其发生发展的关键危险因素。脑源性神经营养因子(BDNF)被认为是介导CHD合并焦虑抑郁共病的病理机制,其通过调节机体炎症反应、改善氧化应激损伤、介导相关信号通路干预本病。CHD合并焦虑抑郁属中医学“胸痹心痛”“郁证”等范畴,中医药治疗本病具备一定疗效。大量研究证实,中药单体、中药复方、传统治法等均能调节BDNF水平,发挥改善CHD合并焦虑抑郁患者心绞痛、焦虑抑郁等。本研究着重阐明BDNF在CHD合并焦虑抑郁的作用机制及中医药的调控作用,旨在为CHD合并焦虑抑郁的新药研发提供新靶点与新思路。

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划——中医药现代化研究重点专项课题(2018YFC1704204); 陕西省重点研发计划——重点产业创新链(群)项目(2024SF-ZDCYL-03-21); 陕西省中医药管理局——长安雷氏心病痰瘀流派传承工作室建设项目[陕中医药发(2018)40号]; 河北省中医药管理局科研计划项目(2024160); 陕西省咸阳市重点研发计划项目(L2023-ZDYF-SF-047); 河北省保定市科技局科技计划项目(2241ZF071)
更新日期/Last Update: 2024-11-11