[1]代雨晴,熊 浪,唐 芳,等.中医药调控中性粒细胞治疗类风湿性关节炎研究进展[J].陕西中医,2024,(11):1576-1578,封3.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.030]
　DAI Yuqing,XIONG Lang,TANG Fang,et al.Research progress of Chinese medicine regulation of neutrophils in treatment of rheumatoid arthritis[J].,2024,(11):1576-1578,封3.[doi:DOI:10.3969/j.issn.1000-7369.2024.11.030]
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中医药调控中性粒细胞治疗类风湿性关节炎研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年11期
页码:
1576-1578,封3
栏目:
综 述
出版日期:
2024-11-05

文章信息/Info

Title:
Research progress of Chinese medicine regulation of neutrophils in treatment of rheumatoid arthritis
作者:
代雨晴1; 熊 浪1; 唐 芳2; 马武开2; 兰维娅2; 蒋 总2; 涂海霞1; 蔡珊燕1
(1.贵州中医药大学,贵州 贵阳 550002; 2.贵州中医药大学第二附属医院,贵州 贵阳 550003)
Author(s):
DAI Yuqing; XIONG Lang; TANG Fang; MA Wukai; LAN Weiya; JIANG Zong; TU Haixia; CAI Shanyan
(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China)
关键词:
类风湿性关节炎;  炎症反应;  中医外治疗法;  中性粒细胞;  中性粒细胞胞外诱捕网
Keywords:
Rheumatoid arthritis;  Inflammatory response;  External treatment of Chinese medicine;  Neutrophils;  Neutrophil extracellular trapping net
分类号:
R 593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2024.11.030
文献标志码:
A
摘要:
近年大量研究证实中性粒细胞(N)通过多种途径诱发类风湿性关节炎(RA)的炎症反应,造成不同程度的关节破坏。调节N已成为防治RA的重要途径。中医药是“国宝”,除了传统抗风湿药、昂贵的生物制剂外,多种中药有效成分、单味药、中药复方和中医外治法均可调节N产生或合成的细胞因子、趋化因子、蛋白酶、活性氧及中性粒细胞胞外诱捕网,改善RA病情进展。故从N在RA中作用机制及基于这些机制的靶向中医药在RA的治疗展开探讨,为临床研究RA提供参考。
Abstract:
In recent years,a large number of studies have confirmed that neutrophil(N)can induce inflammatory response of rheumatoid arthritis(RA)through various ways,then cause different degrees of joint destruction.Therefore,regulating N has become an important way to prevent and treat RA.Traditional Chinese medicine is a “national treasure”.In addition to traditional anti-rheumatic drugs and expensive biologics,variety of effective ingredients of traditional Chinese medicine,single medicine,compound Chinese medicine and external Chinese medicine therapy can regulate N productionor synthesis of cytokines,chemokines,proteases,reactive oxygen species and neutrophil extracellular trapping nets,then improve progression of RA disease.Therefore,mechanism of action of N in RA and targeted traditional Chinese medicine based on these mechanisms in treatment of RA,in order to provide reference for clinical research on RA.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82160917); 贵州省科学技术厅科研项目[黔科合基础-ZK(2023)一般435]; 贵州省大学生创新创业训练计划项目(202110662031); 贵州省高等学校中西医结合防治疾病转化医学重点实验室项目[黔教技(2023)017号]; 贵州中医药大学国家与省级科技创新人才团队培育项目[贵中医TD合字(2022)004号]
更新日期/Last Update: 2024-11-11