[1]彭 艳,邓利萍,范小春,等.小陷胸汤合千金苇茎汤加减治疗慢性阻塞性肺疾病伴肺炎临床研究[J].陕西中医,2024,(12):1649-1653.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.013]
　PENG Yan,DENG Liping,FAN Xiaochun,et al.Clinical study on the treatment of chronic obstructive pulmonary disease with pneumonia by Xiaoxianxiong decoction combined with Qianjin Weijing decoction[J].,2024,(12):1649-1653.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.013]
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小陷胸汤合千金苇茎汤加减治疗慢性阻塞性肺疾病伴肺炎临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1649-1653
栏目:
临床研究
出版日期:
2024-12-05

文章信息/Info

Title:
Clinical study on the treatment of chronic obstructive pulmonary disease with pneumonia by Xiaoxianxiong decoction combined with Qianjin Weijing decoction
作者:
彭 艳1; 邓利萍2; 范小春3; 杨文萍1; 陈 军1; 蒋 莹1; 唐海君1
(1.南充市中医医院内三科,四川 南充 637000; 2.南充市中医医院骨科,四川 南充 637000; 3.筋骨病中医药防治南充市重点实验室,四川 南充 637000)
Author(s):
PENG Yan; DENG Liping; FAN Xiaochun; YANG Wenping; CHEN Jun; JIANG Ying; TANG Haijun
(Department of Internal Medicine,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China)
关键词:
慢性阻塞性肺疾病;  小陷胸汤;  千金苇茎汤;  肺炎;  肺功能;  炎性因子;  中医症状积分
Keywords:
Chronic obstructive pulmonary disease;  Xiaoxianxiong decoction;  Qianjin Weijing decoction;  Pneumonia;  Pulmonary function;  Inflammatory factors;  TCM symptom scores
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2024.12.013
文献标志码:
A
摘要:
目的:探究小陷胸汤合千金苇茎汤加减治疗慢性阻塞性肺疾病(COPD)伴肺炎的效果及对临床症状改善、炎症因子水平的影响。方法:选取82例COPD伴肺炎患者作为研究对象,简单随机(抽签法)分为常规组(n=41)和中西联合组(n=41),常规组患者接受常规治疗,中西联合组在常规组的基础上加用小陷胸汤合千金苇茎汤加减。比较两组患者临床疗效、中医症状积分、COPD严重程度(CAT)、肺功能[第一秒用力呼气容积(FEV1)、每分钟最大通气量(MVV)、FEV1/FVC]、血气指标(SaO2、PaO2、PaCO2)、血清炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]及不良反应。结果:中西联合组治疗总有效率高于常规组(P<0.05)。治疗后,两组咳嗽痰多、喘息气急、胸闷、胸痛、发热评分下降,且治疗后中西联合组低于常规组(均P<0.05)。治疗后,两组CAT评分下降,且中西联合组低于常规组(均P<0.05)。治疗后,两组FEV1、MVV、FEV1/FVC升高,且治疗后中西联合组高于常规组(均P<0.05)。治疗后,两组SaO2、PaO2升高,PaCO2下降(均P<0.05); 且治疗后中西联合组SaO2、PaO2高于常规组(均P<0.05)。治疗后,两组IL-6、CRP、PCT下降,且中西联合组低于常规组(均P<0.05)。常规组出现2例恶心、头晕,中西联合组出现3例恶心、头晕,1例腹胀,组间不良反应比较差异无统计学意义(χ2=0.213,P>0.05)。结论:在常规治疗基础上加用小陷胸汤合千金苇茎汤加减治疗COPD伴肺炎患者临床疗效显著,能有效改善患者肺功能、血气指标,并降低炎性因子水平,同时具备较好的安全性。
Abstract:
Objective:To explore the effect of modified Xiaoxianxiong decoction with Qianjin Weijing decoction in the treatment of chronic obstructive pulmonary disease(COPD)with pneumonia and its influence on clinical symptom improvement and levels of inflammatory factors.Methods:82 patients with COPD complicated with pneumonia were selected as the research subjects,and were divided into conventional group(n=41)and Chinese-western combination group(n=41)by simple randomization(lottery method).The patients in the conventional group received conventional treatment,while the patients in the Chinese-western combination group were added with modified Xiaoxianxiong decoction with Qianjin Weijing decoction on the basis of the conventional group.The clinical efficacy,TCM symptom scores and COPD severity(CAT),pulmonary function(FEV1,MVV,FEV1/FVC),blood gas indicators(SaO2,PaO2,PaCO2)and serum inflammatory factors [interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)] before and after treatment and adverse reactions were compared between both groups.Results:The total effective rate of treatment in Chinese-western combination group was higher than that in conventional group(P<0.05).After treatment,the scores of cough and excessive phlegm,wheezing and shortness of breath,chest tightness,chest pain and fever in the two groups were decreased,and the above scores in Chinese-western combination group were lower than those in conventional group(all P<0.05).The CAT score in the two groups was decreased after treatment,and the CAT score in Chinese-western combination group after treatment was lower than that in conventional group(all P<0.05).After treatment,the FEV1,MVV and FEV1/FVC were enhanced in both groups,and the indicators were higher in Chinese-western combination group after treatment(all P<0.05).After treatment,SaO2 and PaO2 in the two groups were risen,while PaCO2 was reduced(all P<0.05); SaO2 and PaO2 in Chinese-western combination group were higher than those in conventional group after treatment(all P<0.05).The levels of IL-6,CRP and PCT were decreased in the two groups after treatment,and the levels in Chinese-western combination group were lower than those in conventional group(all P<0.05).There were two cases of nausea and dizziness in conventional group,and there were three cases of nausea and dizziness and one case of abdominal distension in Chinese-western combination group(χ2=0.213,P>0.05).Conclusion:On the basis of conventional treatment,the addition of modified Xiaoxianxiong decoction with Qianjin Weijing decoction has significant clinical efficacy in the treatment of COPD patients with pneumonia,and it can effectively improve the pulmonary function and blood gas indicators,and reduce the levels of inflammatory factors,and has good safety.

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备注/Memo

备注/Memo:
基金项目:四川省中医药管理局科研项目(2024MS614); 四川重点实验室科研项目(MIKL202309); 四川省老年学学会课题(2024SCLN0111); 四川省南充市科技局科研项目(22YYJCYJ0064,23YYJCYJ0113)
更新日期/Last Update: 2024-12-05