[1]武晨旭,杨紫音,董建龙,等.基于肥大细胞脱颗粒探讨针刺调节相关信号通路治疗慢性荨麻疹研究进展[J].陕西中医,2024,(12):1722-1725.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.030]
　WU Chenxu,YANG Ziyin,DONG Jianlong,et al.The research progress of acupuncture regulation related signaling pathway in the treatment of chronic urticaria based on mast cell degranulation[J].,2024,(12):1722-1725.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.030]
点击复制

基于肥大细胞脱颗粒探讨针刺调节相关信号通路治疗慢性荨麻疹研究进展
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年12期
页码:
1722-1725
栏目:
综 述
出版日期:
2024-12-05

文章信息/Info

Title:
The research progress of acupuncture regulation related signaling pathway in the treatment of chronic urticaria based on mast cell degranulation
作者:
武晨旭; 杨紫音; 董建龙; 王艳君
(河北中医药大学第一附属医院,河北 石家庄 050011)
Author(s):
WU Chenxu; YANG Ziyin; DONG Jianlong; WANG Yanjun
(The First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang 050011,China)
关键词:
慢性荨麻疹;  肥大细胞;  脱颗粒;  信号通路;  针刺;  过敏反应
Keywords:
Chronic urticaria;  Mast cells;  Degranulation;  Signaling pathways;  Acupuncture;  Anaphylactic reaction
分类号:
R 758.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.12.030
文献标志码:
A
摘要:
慢性荨麻疹(CU)为临床常见的难治性皮肤病,肥大细胞活化和脱颗粒进程异常激活是CU核心发病机制之一,而针刺能够通过多靶点、多途径调动人体免疫系统,分别通过PIP2/IP3/DAG、MAPK、NF-κB、PI3K/PDK1/AKT、JAK/STAT等信号通路抑制肥大细胞脱颗粒进程治疗慢性荨麻疹,临床疗效确切,笔者通过查阅近五年关于慢性荨麻疹相关信号通路的研究,基于肥大细胞脱颗粒总结并分析针刺治疗慢性荨麻疹的相关机制,以期从分子调控、信号通路的视角为针刺治疗慢性荨麻疹提供佐证及治疗策略选择。
Abstract:
Chronic urticaria is a common refractory skin disease in clinical practice,and mast cell activation and abnormal activation of the degranulation process are one of the core pathogenesis of CU.Acupuncture can mobilize the human immune system through multiple targets and pathways,and inhibit the mast cell degranulation process through PIP2/IP3/DAG,MAPK,NF-κB,PI3K/PDK1/AKT,JAK/STAT and other signaling pathways in the treatment of chronic urticaria,with clinical efficacy.By reviewing the research on chronic urticaria related signaling pathways in the past five years,this author summarized and analyzed the relevant mechanisms of mast cell degranulation acupuncture in the treatment of chronic urticaria,in order to provide evidence and treatment strategy options for acupuncture in the treatment of chronic urticaria from the perspective of molecular regulation and signaling pathways.

参考文献/References:

[1] HON K L,LEUNG A K C,NG W G G,et al.Chronic urticaria:An overview of treatment and recent patents[J].Recent Pat Inflamm Allergy Drug Discov,2019,13(1):27-37.
[2] HUANG Y,XIAO Y,ZHANG X,et al.A meta-analysis of observational studies on the association of chronic urticaria with symptoms of depression and anxiety[J].Front Med,2020,2(27):7-39.
[3] 中华医学会皮肤性病学分会荨麻疹研究中心.中国荨麻疹诊疗指南(2022版)[J].中华皮肤科杂志,2022,55(12):1041-1049.
[4] 李黎,史先鹏,周楠,等.烟酰胺腺嘌呤二核苷酸磷酸氧化酶-活性氧氧化应激信号通路在过敏反应中的作用及抗氧化剂干预实验研究[J].陕西医学杂志,2023,52(6):640-644.
[5] 雷小丽,谭帅,刘佳,等.桂枝汤加减治疗产后荨麻疹疗效观察[J].陕西中医,2023,44(9):1208-1211.
[6] BANAFEA G H,BAKHASHAB S,ALSHAIBI H F,et al.The role of human mast cells in allergy and asthma[J].Bioengineered,2022,13(3):7049-7064.
[7] SAINI S S.Chronic spontaneous urticaria:Etiology and pathogenesis[J].Immunol Allergy Clin North Am,2014,34(1):33-52.
[8] BRACKEN S J,ABRAHAM S,MACLEOD A S.Autoimmune theories of chronic spontaneous urticaria[J].Front Immunol,2019,29(10):627.
[9] CHURCH M K,KOLKHIR P,METZ M,et al.The role and relevance of mast cells in urticaria[J].Immunol Rev,2018,282(1):232-247.
[10] 张小红,马铁明,明彩荣,等.电针对荨麻疹大鼠皮下疏松结缔组织中肥大细胞Lyn、Syk表达的影响[J].中国针灸,2020,40(7):765-770.
[11] XU M,ZHU B,CAO X,et al.OSBP-related protein 5L maintains intracellular IP3/Ca2+ signaling and proliferation in T cells by facilitating pip2 hydrolysis[J].J Immunol,2020,204(5):1134-1145.
[12] CHAKI S,ALKANFARI I,ROY S,et al.Inhibition of orai channel function regulates mas-related G protein-coupled receptor-mediated responses in mast cells[J].Front Immunol,2022,12(1):803335.
[13] LIANG Y,KONG Q,LUO H,et al.Exploring long non-coding RNAs associated with IP3/DAG signaling pathway as potential biomarkers involved in mast cell degranulation in chronic spontaneous urticaria with 2-year follow-up[J].J Inflamm Res,2022,15(1):267-283.
[14] 郭静,肖敏,左小红,等.基于久病入络理论的当归饮子通过调控PIP2/IP3/DAG信号通路对荨麻疹的防治及其机理研究[J].时珍国医国药,2015,26(10):2333-2335.
[15] 陶金卓.基于PIP2/IP3/Ca2+信号通路针刺血海、曲池穴治疗慢性荨麻疹的作用机制研究[D].沈阳:辽宁中医药大学,2019.
[16] 张小红,李飞飞,齐越,等.电针对荨麻疹大鼠腹腔肥大细胞中丝裂原活化蛋白激酶及细胞因子表达的影响[J].针刺研究,2020,45(4):299-304.
[17] STANKOVIC M,VELJOVIC K,POPOVIC N,et al.Lactobacillus brevis BGZLS10-17 and Lb.plantarum BGPKM22 exhibit anti-inflammatory effect by attenuation of NF-κB and MAPK signaling in human bronchial epithelial cells[J].Int J Mol Sci,2022,23(10):5547.
[18] CORRE I,PARIS F,HUOT J.The p38 pathway,a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells[J].Oncotarget,2017,8(33):55684-55714.
[19] CHEN Y,LIU K,QIN Y,et al.Effects of pereskia aculeate miller petroleum ether extract on complete freund's adjuvant-induced rheumatoid arthritis in rats and its potential molecular mechanisms[J].Front Pharmacol,2022,13(5):869810.
[20] TOURNIER C,DONG C,TURNER T K,et al.MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines[J].Genes Dev,2001,15(11):1419-1426.
[21] LI L,JIN G,JIANG J,et al.Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways[J].Biochem Biophys Res Commun,2016,473(2):408-414.
[22] PARK J H,HWANG M H,CHO Y R,et al.Combretum quadrangulare extract attenuates atopic dermatitis-like skin lesions through modulation of MAPK signaling in BALB/c mice[J].Molecules,2020,25(8):2003.
[23] WANG Y,ZHANG P,ZHANG J,et al.Bisdemethoxycurcumin attenuates OVA-induced food allergy by inhibiting the MAPK and NF-κB signaling pathways[J].Exp Ther Med,2022,23(6):401.
[24] ZHANG X H,LI F F,QI Y,et al.Electroacupuncture improves cutaneous allergic reaction by inhibiting degranulation of intrape-ritoneal mast cells,MAPK signaling and inflammatory factor levels in urticaria rats[J].Zhen Ci Yan Jiu,2020,45(4):299-304.
[25] 杨芳,高素文,刘旋,等.丹参酮ⅡA通过调控p38MAPK/NF-κB信号通路减轻糖尿病雄性大鼠生殖损伤实验研究[J].陕西医学杂志,2024,53(5):610-615.
[26] 李市荣,王西双,程国良,等.基于NF-κB/NLRP3/IL-1β信号通路探讨荆防合剂对荨麻疹小鼠干预作用的研究[J].中国中药杂志,2022,47(20):5467-5472.
[27] PARK J E,KANG E,HAN J S.HM-chromanone attenuates TNF-α-mediated inflammation and insulin resistance by controlling JNK activation and NF-κB pathway in 3T3-L1 adipocytes[J].Eur J Pharmacol,2022,921(4):174884.
[28] XIE C C,ZHANG B P,WANG H N,et al.Flavoring agent dihydrocoumarin alleviates IgE-mediated mast cell activation and allergic inflammation[J].Food Funct,2022,13(6):3621-3631.
[29] KESSEL A,BISHARA R,AMITAL A,et al.Increased plasma levels of matrix metalloproteinase-9 are associated with the severity of chronic urticaria[J].Clin Exp Allergy,2005,35(2):221-225.
[30] 张小红.电针调控荨麻疹大鼠肥大细胞 MAPK/NF-κB信号通路发挥抗过敏作用的实验研究[D].沈阳:辽宁中医药大学,2020.
[31] ZHAO J W,PING J D,WANG Y F,et al.Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1α pathway in chronic spontaneous urticaria[J].Clin Immunol,2020,215(6):108444.
[32] 韦薇,覃骊兰,李莉,等.基于PI3K/Akt/mTOR信号通路探讨玉屏风散对肥大细胞脱颗粒的影响[J].环球中医药,2021,14(9):1580-1586.
[33] 刘白雪,李记泉,李思佳,等.基于PI3K/PDK1/AKT信号通路探究电针对荨麻疹大鼠皮肤肥大细胞脱颗粒的影响[J].中华中医药杂志,2022,37(5):2866-2870.
[34] SHAWKY A M,ALMALKI F A,ABDALLA A N,et al.A comprehensive overview of globally approved JAK inhibitors[J].Pharmaceutics,2022,14(5):1001.
[35] FENG H,FENG J,ZHANG Z,et al.Role of IL-9 and IL-10 in the pathogenesis of chronic spontaneous urticaria through the JAK/STAT signalling pathway[J].Cell Biochem Funct,2020,38(4):480-489.
[36] 林永丽,孙亚飞,杨灿.依巴斯汀、脾氨肽联合自血穴位注射治疗ASST(+)慢性荨麻疹疗效及对患者免疫炎性因子的影响[J].陕西中医,2019,40(4):502-504.

相似文献/References:

[1]林永丽,孙亚飞,杨 灿.依巴斯汀、脾氨肽联合自血穴位注射治疗ASST(+)慢性荨麻疹疗效 及对患者免疫炎性因子的影响*[J].陕西中医,2019,(4):502.
　LIN Yongli,SUN Yafei,YANG Chan..Therapeutic effect of ebastine and splenomegaly combined with autoblood point injection in treatment of chronic urticaria of ASST (+) and its effect on immunoinflammatory cytokines[J].,2019,(12):502.
[2]陈思清,徐 寅,蔺晓源,等.四磨汤对肝脾气滞证功能性消化不良大鼠十二指肠低度炎症及肥大细胞脱颗粒的影响[J].陕西中医,2023,(10):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]
　CHEN Siqing,XU Yin,LIN Xiaoyuan,et al.Effect of Simo decoction on low-grade inflammation of duodenum and degranulation of mast cells in rats with functional dyspepsia[J].,2023,(12):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]

备注/Memo

备注/Memo:
基金项目:国家重点研发计划项目(2017YFC1703600); 河北省自然科学基金资助项目(H2022423350)
更新日期/Last Update: 2024-12-05