[1]高玖妹,高金金,梁锦铃,等.基于LncRNA探讨多囊卵巢综合征的发病机制与中医药干预研究进展[J].陕西中医,2025,46(1):134-138.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.030]
　GAO Jiumei,GAO Jinjin,LIANG Jinling,et al.Research progress on pathogenesis of polycystic ovary syndrome and traditional Chinese medicine intervention based on LncRNA[J].,2025,46(1):134-138.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.030]
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基于LncRNA探讨多囊卵巢综合征的发病机制与中医药干预研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年1期
页码:
134-138
栏目:
综 述
出版日期:
2025-01-05

文章信息/Info

Title:
Research progress on pathogenesis of polycystic ovary syndrome and traditional Chinese medicine intervention based on LncRNA
作者:
高玖妹1; 高金金2; 梁锦铃1 ; 赵德敏1; 张 新1; 孙 淼2; 马 明2; 刘颖华3; 徐 芳2
(1.黑龙江中医药大学,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040; 3.江南大学附属妇产医院,江苏 无锡 214122)
Author(s):
GAO Jiumei; GAO Jinjin; LIANG Jinling; ZHAO Demin; ZHANG Xin; SUN Miao; MA Ming; LIU Yinghua; XU Fang
(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
关键词:
多囊卵巢综合征;  长链非编码RNA;  发病机制;  中医药;  胰岛素抵抗;  高雄激素血症;  肥胖
Keywords:
Polycystic ovary syndrome;  Long non-coding RNA;  Pathogenesis;  Traditional Chinese medicine;  Insulin resistance;  Hyperandrogenemia;  Obesity
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.01.030
文献标志码:
A
摘要:
多囊卵巢综合征(PCOS)是临床常见的生殖代谢性疾病,影响很多女性的心理健康和生活质量。伴随分子生物学的不断进步,长链非编码RNA(LncRNA)已被证明在PCOS的发生发展中具有关键作用。中医药具有多靶点、多通路、副作用小、治愈率高等特点,在防治PCOS中有显著的临床疗效,但其分子机制尚未明确。本文就多种 LncRNA参与PCOS及其并发症的发病机制进行综述,总结目前中药单体、复方及中医特殊疗法通过调控LncRNA改善PCOS及其并发症的研究进展,为明确PCOS的发病机制提供理论依据,为中医药改善PCOS提供新的作用靶点,为疾病的临床防治提供新思路。
Abstract:
Polycystic ovary syndrome(PCOS)is a clinically common metabolic syndrome that affects the mental health and quality of life of many women.With the continuous exploration and development of molecular biology,Long non-coding RNA(LncRNA)has been shown to play an important role in the occurrence and development of PCOS.Traditional Chinese medicine(TCM)has the characteristics of multi-target,multi-pathway,small side effects and high cure rate,and has significant clinical effect in the prevention and treatment of PCOS,but its molecular mechanism has not been clarified.The article reviews the pathogenisis of various LncRNA involved in PCOS and its complications,and summarizes the current research progress of TCM monomer,compound and special therapy to improve PCOS and its complications by regulating LncRNA.so as to provide theoretical basis for clarifying the pathogenesis of PCOS.It provides a new target for improving PCOS by TCM and a new idea for clinical prevention and treatment of disease.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(82174195); 国家自然科学基金青年科学基金资助项目(82004401); 黑龙江省自然科学基金资助项目(LH2023H061); 黑龙江省中医药科研项目(ZHY2023-018)
更新日期/Last Update: 2025-01-09