[1]陈凡平,宁红霞,汪海波,等.大黄虫丸联合西药治疗下肢动脉硬化闭塞症疗效研究[J].陕西中医,2025,46(3):364-367.[doi:DOI:10.3969/j.issn.1000-7369.2025.03.016]
　CHEN Fanping,NING Hongxia,WANG Haibo,et al.Study on application of Dahuang Zhechong pill combined with conventional western medicine in treatment of arteriosclerosis obliterans of lower limbs[J].,2025,46(3):364-367.[doi:DOI:10.3969/j.issn.1000-7369.2025.03.016]
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大黄虫丸联合西药治疗下肢动脉硬化闭塞症疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年3期
页码:
364-367
栏目:
临床研究
出版日期:
2025-03-05

文章信息/Info

Title:
Study on application of Dahuang Zhechong pill combined with conventional western medicine in treatment of arteriosclerosis obliterans of lower limbs
作者:
陈凡平; 宁红霞; 汪海波; 杨晓萌; 祁爱风
(石家庄市中医院,河北 石家庄 050051)
Author(s):
CHEN Fanping; NING Hongxia; WANG Haibo; YANG Xiaomeng; QI Aifeng
(Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang 050051,China)
关键词:
下肢动脉硬化闭塞症;  大黄虫丸;  西洛他唑;  血管通畅率;  皮肤温度感;  可溶性微纤维相关蛋白4
Keywords:
Lower limb arteriosclerosis obliterans;  Dahuang Zhechong pill;  Cilostazol;  Vascular patency rate;  Skin temperature sensation;  Soluble microfiber associated protein 4
分类号:
R 255.7
DOI:
DOI:10.3969/j.issn.1000-7369.2025.03.016
文献标志码:
A
摘要:
目的:探究大黄虫丸联合常规西药治疗下肢动脉硬化闭塞症(ASO)的临床疗效。方法:选择90例ASO患者,按随机数字表法分为两组,各45例。单用药组使用西洛他唑治疗,联合用药组加用大黄虫丸治疗。比较两组患者血管通畅率、皮肤温度感、血清学指标和临床疗效。结果:治疗后,两组血管内径、峰值流速、血流量均提高,且联合用药组峰值流速、血流量提高更显著(P<0.05)。治疗后两组患者皮温均升高,且联合用药组升高更明显(P<0.05)。一氧化氮(NO)和可溶性微纤维相关蛋白4(sMFAP4)在两组治疗后均上升,内皮素-1(ET-1)均下降,且联合用药组各项指标上升及下降均较单独用药组更显著(P<0.05)。两组临床总有效率分别为联合用药组97.78%、单用药组82.22%,组间比较差异有统计学意义(P<0.05)。结论:大黄虫丸联合西洛他唑能够有效促进ASO患者血管畅通,提高皮肤温度,改善血清sMFAP4水平。
Abstract:
Objective:To explore clinical effect of Dahuang Zhechong pill combined with conventional western medicine in lower extremity arteriosclerosis obliteration(ASO).Methods:90 ASO patients were divided into 45 control group and 45 observation group by random number table method.The single-drug group were treated with ciloprazole,and the combined drug group were treated with Dahuang Zhechong pill.The vascular patency rate,skin temperature sensation,serological indexes and clinical efficacy of the two groups were compared.Results:After treatment,internal diameter,peak velocity and blood flow of the two groups were increased,and the increases of peak velocity and blood flow were more significant in the combination group(P<0.05).After treatment,the skin temperature of both groups was increased,and the increase was more obvious in the combined treatment group(P<0.05).After treatment,the skin temperature of both groups was increased,and the increase was more obvious in the combined treatment group(P<0.05).Nitric oxide(NO)and soluble microfiber-associated protein 4(sMFAP4)were both increased and endothelin-1(ET-1)were decreased after treatment in both groups,and the increase and decrease of various indexes in the combined treatment group were more significant than those in the single treatment group(P<0.05).The total clinical effective rate of the two groups was 97.78% in the combined drug group and 82.22% in the single drug group,and the clinical effect of the combined drug group was significantly higher(P<0.05).Conclusion:The combination of Dahuang Zhechong pill and cilostazol can effectively promote vascular patency,increase skin temperature,and improve serum sMFAP4 level in ASO patients.

参考文献/References:

[1] 高向琴,张云霞.彩色多普勒超声在下肢动脉硬化闭塞症诊断中的价值及对临床治疗指导意义研究[J].陕西医学杂志,2019,48(6):759-761.
[2] 周智勇,李莹.马来酸桂哌齐特联合西洛他唑治疗下肢动脉硬化闭塞症的临床研究[J].疾病监测与控制,2022,16(5):337-339.
[3] 陆爽爽,刘遵,史伟浩,等.下肢动脉硬化闭塞症患者腔内治疗术后运动及患侧肢体侧支血管的现况调查[J].中国医学计算机成像杂志,2023,29(2):191-195.
[4] 唐辉,所世腾,俞璐,等.下肢动脉硬化闭塞症患者血管成形术后ASL及IVIM灌注与侧支循环的比较分析[J].中国医学计算机成像杂志,2023,29(3):295-299.
[5] 朱盛兴,张雷,焦小平,等.脉管复康片联合西洛他唑治疗下肢动脉硬化闭塞症的临床研究[J].现代药物与临床,2021,36(12):2569-2573.
[6] 王前,李沛瑾,李光宗,等.四位当代名医治疗早期下肢动脉硬化性闭塞症思想[J].西部中医药,2023,36(10):49-52.
[7] 李晓庆,黄天一.活血通脉汤加减治疗血脉瘀阻型下肢动脉硬化闭塞症的临床研究[J].河北中医,2022,44(2):234-238.
[8] 宋少伟,路瑷雯,董燕平,等.大黄虫丸防治动脉粥样硬化的作用机制及临床研究进展[J].现代中西医结合杂志,2022,31(24):3495-3499.
[9] CRONENWETT J L,JOHNSTON K W,郭伟,等译.卢瑟福血管外科学[M].第七版.北京:北京大学医学出版社,2013:734-751.
[10] 中华医学会外科学分会血管外科学组.下肢动脉硬化闭塞症诊治指南[J].中华普通外科学文献:电子版,2016,10(1):1-18.
[11] 国家中医药管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:143-144.
[12] 杜自忠,王晨,张明星,等.下肢动脉硬化闭塞症患者介入治疗后血清miR-342-5p水平及其意义[J].介入放射学杂志,2020,29(9):894-898.
[13] 王海红,郑学军.动脉二号加减方治疗下肢动脉硬化闭塞症的疗效及对血液流变学的影响[J].中药材,2023,46(11):2870-2875.
[14] 朱晴,牛轶.阿司匹林联合氯吡格雷、双嘧达莫在下肢动脉硬化闭塞症中治疗效果及对血小板功能的影响[J].中国老年学杂志,2021,41(10):2117-2120.
[15] 王伟,王藏慧,徐学灵.内膜下血管成形术联合西洛他唑治疗动脉粥样硬化闭塞症临床研究[J].中国药业,2020,29(20):61-63.
[16] 刘文杰,涂玥,何伟明,等.大黄虫丸通过PI3K/AKT/HIF-1α信号通路减轻心肌细胞凋亡而延缓心脏衰老的作用机制 [J/OL].中国中药杂志,1-12[2024-12-11].https://doi.org/10.19540/j.cnki.cjcmm.20241015.401.
[17] 贾新能,宣俊毅,金佳琪.益气活血化瘀方治疗血脉瘀阻型下肢动脉硬化闭塞症49例[J].浙江中医杂志,2023,58(4):266-267.
[18] 陈晓朋.温针灸治疗下肢动脉硬化闭塞症的效果观察[J].现代医学与健康研究电子杂志,2021,5(13):95-97.
[19] 王转转,顾民华,李光智,等.大黄虫丸通过NF-κB信号通路调节动脉粥样硬化大鼠血脂及炎症相关指标水平[J].中国老年学杂志,2024,44(12):2917-2921.
[20] 荣宝山,石志强,翟佳滨.大黄虫丸临床应用及实验研究进展[J].中华中医药学刊,2024,42(8):54-58.
[21] 田浩,郑翔,闻作川,等.ASO患者血管介入术后ET-1、sTREM-1、VEGF水平对血管再狭窄发生的预测价值[J].中国病案,2023,24(1):106-109.
[22] 刁冰冰,梁群.化纤胶囊Ⅱ号方治疗脓毒症急性肺损伤疗效及对患者血管内皮细胞功能、毛细血管渗漏指数的影响[J].陕西中医,2023,44(1):45-49.
[23] 张鹤,张涛,张花平,等.虫类药物治疗下肢动脉硬化闭塞症的效果及对血管内皮功能的影响[J].临床误诊误治,2022,35(6):40-43.
[24] 李倩.“醒脑开窍”针刺法对脑中风后遗症患者血清炎症因子及血管内皮功能的影响[J].陕西中医,2022,43(1):114-117.
[25] 张名林,史键山,邓堂,等.血清sMFAP4水平对下肢闭塞性动脉硬化患者支架植入术后6个月再狭窄的预测价值[J].血管与腔内血管外科杂志,2021,7(7):816-820.

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备注/Memo

备注/Memo:
[基金项目]河北省中医药管理局科研计划项目(2023377)
更新日期/Last Update: 2025-03-10