[1]董小天,周美惠.祛风散结汤联合中药熏蒸治疗神经性皮炎疗效研究[J].陕西中医,2025,46(4):495-498.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.013]
　DONG Xiaotian,ZHOU Meihui.Curative effect of Qufeng Sanjie decoction combined with Chinese herbal fumigation in treatment of neurodermatitis[J].,2025,46(4):495-498.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.013]
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祛风散结汤联合中药熏蒸治疗神经性皮炎疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年4期
页码:
495-498
栏目:
临床研究
出版日期:
2025-04-20

文章信息/Info

Title:
Curative effect of Qufeng Sanjie decoction combined with Chinese herbal fumigation in treatment of neurodermatitis
作者:
董小天; 周美惠
(解放军东部战区空军医院,江苏 南京 210000)
Author(s):
DONG Xiaotian; ZHOU Meihui
(Traditional Chinese Medicine Department,Air Force Hospital in the Eastern War Zone of the Chinese People's Liberation Army,Nanjing 210000,China)
关键词:
神经性皮炎;  祛风散结汤;  Th1/Th2细胞因子;  P物质;  单胺氧化酶;  生活质量
Keywords:
Neurodermatitis;  Qufeng Sanjie decoction;  Th1/Th2 cytokines;  Substance P;  Monoamine oxidase;  Quality of life
分类号:
R 758.3
DOI:
DOI:10.3969/j.issn.1000-7369.2025.04.013
文献标志码:
A
摘要:
目的:探讨祛风散结汤联合中药熏蒸治疗神经性皮炎的疗效及对患者外周血Th1/Th2细胞因子、P物质(SP)、单胺氧化酶(MAO)的影响。方法:选取90例神经性皮炎患者,采用数字表法分为对照组、研究组,每组45例,对照组采用丙酸氯倍他索乳膏治疗,研究组采用中药熏蒸、口服中药联合丙酸氯倍他索乳膏治疗,两组均治疗4周。对比两组患者EASI评分、VAS评分、DLQI评分、外周血Th1/Th2细胞因子水平、血清SP、MAO水平和总体疗效。结果:治疗后研究组EASI、VAS、DLQI评分较治疗前降低,且研究组评分低于对照组(均P<0.05)。治疗后研究组、对照组血清IFN-䥺SymbolgA@、IL-2水平升高,IL-4、IL-5水平降低(均P<0.05); 研究组血清IFN-䥺SymbolgA@、IL-2水平明显高于对照组,IL-4、IL-5水平显著低于对照组(均P<0.05)。治疗后研究组、对照组血清SP、MAO水平降低,研究组血清SP、MAO水平明显低于对照组(均P<0.05); 研究组总有效率高于对照组(P<0.05)。结论:祛风散结汤联合中药熏蒸及丙酸氯倍他索乳膏治疗ND可缩短病程,显著提高临床疗效,改善患者生活质量,且用药安全。
Abstract:
Objective:To investigate the curative effect of Qufeng Sanjie decoction combined with Chinese medicine fumigation in the treatment of neurodermatitis and the influence on Th1/Th2 cytokines,Substance P(SP)and monoamine oxidase(MAO)in peripheral blood of patients.Methods:90 patients with neurodermatitis were selected and divided into a control group and a study group using a digital table method,with 45 patients in each group.The control group was treated with chlorhexidine propionate cream,while the study group was treated with traditional Chinese medicine fumigation,oral Chinese medicine combined with chlorhexidine propionate cream.Both groups were treated for 4 weeks.Compare the EASI score,VAS score,DLQI score,peripheral blood Th1/Th2 cytokine levels,serum SP,MAO levels,and overall efficacy between two groups of patients.Results:After treatment,EASI,VAS and DLQI scores of the study group were lower than those before treatment,and the scores of the study group were lower than those of the control group(all P<0.05).After treatment,the serum levels of IFN-γ and IL-2 in study group and control group were increased,while the levels of IL-4 and IL-5 were decreased(all P<0.05).Serum IFN-γ and IL-2 levels of study group were significantly higher than those of control group,and serum IL-4 and IL-5 levels were significantly lower than those of control group(all P<0.05).After treatment,the serum SP and MAO levels in the study group and the control group were decreased,and the serum SP and MAO levels in the study group were significantly lower than those in the control group(all P<0.05).The total effective rate of the study group were higher than those of the control group(P<0.05).Conclusion:Qufeng Sanjie decoction combined with traditional Chinese medicine fumigation and clobetasol propionate cream in the treatment of ND can shorten the course of the disease,significantly improve the clinical effect,improve the quality of life of patients,and the drug is safe.

参考文献/References:

[1] 由佩然,朱闽.石膏解肌法在神经性皮炎治疗中的应用 [J].中国中医急症,2024,33(5):918-921.
[2] 李静怡,姜振刚,王星星,等.“从血论治”神经性皮炎撷要[J].河北中医,2023,45(7):1172-1175.
[3] 张汪林,王建锋,方莹莹,等.单栀逍遥散加减联合火针治疗肝郁化火证神经性皮炎临床观察 [J].山西中医,2023,39(9):36-38.
[4] YANG L,LI X Y,HUANG W,et al.The efficacy and safety of acupuncture in the treatment of neurodermatitis:A systematic review and meta-analysis[J].Evid Based Complement Alternat Med,2022,1:8182958.
[5] 李昉恒,吴华江,陆英.养血祛风消癣汤联合西药治疗神经性皮炎的临床观察[J].中国中医药科技,2020,27(6):954-946.
[6] 中华中医药学会.中国皮肤科常见病诊疗指南[M].北京:中国中医药出版社,2022:240-250.
[7] HANFIN J M,THURSTON M,OMOTO M,et al.The eczema area and severity index(EASI):Assessment of reliability in atopic dermatitis.EASI Evaluator Group[J].Exp Dermatol,2001,10(1):11-18.
[8] 杨志波,周小勇.湿疹中西医诊疗指南[M].北京:人民军医出版社,2013:120.
[9] AN J G,LIU Y T,XIAO S X,et al.Quality of life of patients with neurodermatitis[J].Int J Med Sci,2013,10(5):593-598.
[10] 鞠延娇,李沐风,谢志强.特应性皮炎患者皮肤搔挖及焦虑抑郁情绪评估[J].中国皮肤性病学杂志,2021,35(8):921-924.
[11] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:277-278.
[12] 陈曼珍,王倩.梅花针治疗局限性神经性皮炎的临床观察[D].广州:广州中医药大学,2013.
[13] 杨瑞,杨波,王文成,等.临床治疗神经性皮炎研究进展[J].陕西中医药大学学报,2019,42(6):164-168.
[14] 海琳娜,李志刚.中医熏药疗法在皮肤病中临床应用概述[J].新疆中医药,2019,37(6):131-132.
[15] 张凡,王绾江,景慧玲.紫草的现代药理研究及皮肤科中的应用[J].中医药导报,2020,26(9):168-172.
[16] 陈佳骏,杨妞妞.白鲜皮及其活性成分抗炎止痒机制研究进展[J].江西中医药,2020,5(51):78-80.
[17] 宋颜君,许利嘉,缪剑华,等.野菊花的研究进展[J].中国现代中药,2020,10(22):1751-1761.
[18] 徐定平,周鑫堂,郜红利,等.千里光化学成分和药理作用研究进展[J].中国药师,2014,17(9):1562-1565.
[19] 王津燕.中药黄芩药理作用的研究进展[J].内蒙古中医药,2020,39(2):167-168.
[20] 王俊民,韩海成,李卓雅,等.复方黄柏液联合盐酸司他斯汀片对急性面部湿疹患者Th1/Th2类指标的影响[J].陕西中医,2019,10(40):1428-1430.
[21] 李晶晶,陈颖,王阳,等.归芪藤草膏对外阴慢性单纯性苔藓大鼠肝肾功能及Th1/Th2免疫机制的影响 [J].现代中西医结合杂志,2022,31(17):2369-2373.
[22] 陆地,孙玲玲.火针加灸法为主治疗神经性皮炎的疗效及对外周血Th1/Th2细胞调控的影响[J].上海针灸杂志,2019,10(38):1131-1135.
[23] LAURITANO D,MASTRANGELO F,D'OVIDIO C,et al.Activation of mast cells by neuropeptides:The role pro-inflammatory and anti-inflammatory cytokines[J].Int J Mol Sci,2023,24(5):4811.
[24] 金曼诗,马铁明,李记泉,等.P物质在皮肤源性瘙痒发病机制中的研究进展[J].中国医药导报,2024,21(1):49-52.
[25] 李小艳,高瑞,许晓蕾.自拟止痒散结汤结合中医火针对神经性皮炎T细胞亚群及外周血P物质、MAO的影响[J].辽宁中医杂志,2022,49(5):110-114.

备注/Memo

备注/Memo:
[基金项目]江苏省高校自然科学基金资助面上项目(KJ2023C001-D030)
更新日期/Last Update: 2025-04-08