[1]白月洁,王子涵,王 辰,等.基于“虚气留滞”理论探讨线粒体质量控制失衡对特发性肺纤维化的影响[J].陕西中医,2025,46(4):517-521.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.018]
　BAI Yuejie,WANG Zihan,WANG Chen,et al.The effect of mitochondrial quality control imbalance on idiopathic pulmonary fibrosis based on the theory of “Xuqi stagnation”[J].,2025,46(4):517-521.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.018]
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基于“虚气留滞”理论探讨线粒体质量控制失衡对特发性肺纤维化的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年4期
页码:
517-521
栏目:
学术探讨
出版日期:
2025-04-20

文章信息/Info

Title:
The effect of mitochondrial quality control imbalance on idiopathic pulmonary fibrosis based on the theory of “Xuqi stagnation”
作者:
白月洁1; 王子涵2; 王 辰1; 刘美苹3; 邵雨萌1; 朱 雪4; 张心月4
(1.山东中医药大学,山东 济南 250355; 2.首都医科大学附属北京友谊医院中医科,北京 100050; 3.烟台市蓬莱中医医院,山东 烟台 265800; 4.山东中医药大学附属医院,山东 济南 250014)
Author(s):
BAI Yuejie1; WANG Zihan2; WANG Chen1; LIU Meiping3; SHAO Yumeng1; ZHU Xue4; ZHANG Xinyue4
(1.Shandong University of Traditional Chinese Medicine,Jinan 250355,China; 2.Department of Traditional Chinese Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China; 3.Yantai Penglai Hospital of Traditional Chinese Medicine Yantai,Yantai 265800,China; 4.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
关键词:
特发性肺纤维化;  虚气留滞;  线粒体质量控制;  线粒体稳态失调;  内质网应激;  线粒体质量控制相关通路
Keywords:
Idiopathic pulmonary fibrosis;  Xuqi stagnation;  Mitochondrial quality control;  Dysregulation of mitochondrial homeostasis;  Endoplasmic reticulum stress;  Mitochondrial quality control related pathways
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2025.04.018
文献标志码:
A
摘要:
特发性肺纤维化(IPF)是一种隐匿性的、呈慢性进行性的、不可逆的、病因不明的弥漫性肺部疾病,该病预后较差,病死率较高。细胞表面活性物质的积累在一定程度上促进了IPF发病。线粒体质量控制(MQC)是导致活性物质积累的关键因素。MQC失衡会引起炎症因子聚集,攻击损伤的线粒体,导致线粒体稳态失调,使损伤的伤线粒体积累,进而导致活性物质的沉积。“虚气留滞”是指元气虚损,气化功能失常,毒邪留滞体内而损伤脏腑。中医认为,IPF以肺心脾肾气虚为本,气化障碍致水液停聚生成水饮、痰浊、瘀血等病理产物为标。故“虚气留滞”是IPF的基本病机。线粒体与气在生理病理上具有高度的相似性,是气的微观表现之一。MQC的作用与气功能相似。目前调控MQC失衡来改善IPF已成为研究的重点方向,故笔者将“虚气留滞”病机与MQC失衡运用取象比类的方式结合,加之对MQC的现代医学认识,探讨二者之间的相关性,并确立“扶正补虚治其本、行滞化瘀治其标”的基本治则,以期为未来临床中医药治疗IPF进一步提供新视角。
Abstract:
Idiopathic pulmonary fibrosis(IPF)is an insidious,chronically progressive,irreversible,diffuse lung disease with no clear cause,which has a poor prognosis and a high mortality rate.The accumulation of active substances on the cell surface promotes IPF to some extent.And mitochondrial quality control(MQC)is the key to the accumulation of active substances.MQC imbalance causes inflammatory factors to accumulate and attack damaged mitochondria,leading to dysregulation of mitochondrial homeostasis,which results in the accumulation of damaged mitochondria,and consequently the deposition of reactive substances.Xuqi stagnation refers to the deficiency of Yuanqi and the malfunction of Qi-transformation which leads to the toxicity that stays in the body and damages the internal organs.Traditional Chinese medicine believes that IPF is based on the Qi deficiency of “lung,heart,spleen and kidney”,and the obstruction of Qi-transformation leads to the accumulation of water and fluid to produce pathological products such as water,phlegm-turbidity,blood stasis,etc. as the symptoms.Therefore,“Xuqi stagnation” is the basic pathogenesis of IPF.Mitochondria has a high degree of physiopathological similarity to Qi and is one of the microscopic manifestations of Qi.The role of MQC is similar to the function of Qi.Currently,modulating MQC imbalance to improve IPF has become the focus of research efforts.Therefore,the author combines the disease mechanism of “Xuqi stagnation” with the imbalance of MQC by taking images and comparing them with analogies,together with the modern medical understanding of MQC,to explore the correlation between the two and to establish the basic treatment principle of “supporting and replenishing the deficiency to treat the root of the disease and promoting stagnation and resolving stasis to treat the symptoms”,in order to provide further perspectives for clinical Chinese medicine to treat IPF in the future.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(82104799)
更新日期/Last Update: 2025-04-08