[1]陈希阳,朱才丰,杨高尚,等.火针焠灸联合针刺治疗卒中后失眠临床研究[J].陕西中医,2025,46(4):555-558,563.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.026]
　CHEN Xiyang,ZHU Caifeng,YANG Gaoshang,et al.Clinical study on fire needle tempering and moxibustion combined with acupuncture in the treatment of post-stroke insomnia[J].,2025,46(4):555-558,563.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.026]
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火针焠灸联合针刺治疗卒中后失眠临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年4期
页码:
555-558,563
栏目:
针灸经络
出版日期:
2025-04-20

文章信息/Info

Title:
Clinical study on fire needle tempering and moxibustion combined with acupuncture in the treatment of post-stroke insomnia
作者:
陈希阳1; 朱才丰2; 杨高尚1; 谢苗苗1; 袁心怡1; 叶淑琦1; 张振丰1
(1.安徽中医药大学研究生院,安徽 合肥 230012; 2.安徽中医药大学第二附属医院,安徽 合肥 230061)
Author(s):
CHEN Xiyang1; ZHU Caifeng2; YANG Gaoshang1; XIE Miaomiao1; YUAN Xinyi1; YE Shuqi1; ZHANG Zhenfeng1
(1.Graduate School of Anhui University of Traditional Chinese Medicine,Hefei 230012,China; 2.The Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230061,China)
关键词:
卒中;  失眠;  针刺;  炎症因子;  神经递质;  白细胞介素
Keywords:
Stroke;  Insomnia;  Acupuncture;  Inflammatory factor;  Neurotransmitter;  Interleukin
分类号:
R 246.6
DOI:
DOI:10.3969/j.issn.1000-7369.2025.04.026
文献标志码:
A
摘要:
目的:观察火针焠灸联合针刺治疗卒中后失眠(PSI)的临床疗效。方法:选取70例PSI患者,随机分为观察组和对照组,每组35例。在西医基础治疗及常规康复训练的基础上,对照组予以常规针刺治疗; 观察组在对照组治疗基础上,予以火针焠灸治疗。两组均隔日1次,每周3次,共治疗4周。于治疗前后及治疗结束后2周评定匹兹堡睡眠质量指数(PSQI)、美国国立卫生研究院卒中量表(NIHSS)、失眠严重程度指数(ISI)及疲劳评估量表(FAS)评分。于治疗前后检测血清白细胞介素(IL)-1β、IL-2、降钙素原(PCT)、谷氨酸(Glu)及γ-氨基丁酸(GABA)水平和Glu/GABA比值,并评定疗效和安全性。结果:与治疗前比较,两组PSQI、NIHSS、ISI及FAS评分降低(均P<0.05),IL-1β、IL-2、PCT、Glu水平及Glu/GABA比值降低(均P<0.05),GABA水平升高(均P<0.05),且观察组各项指标降低或升高更显著(均P<0.05)。观察组总有效率91.43%显著高于对照组的77.14%(P<0.05)。治疗期间,两组均未出现不良反应。结论:火针焠灸联合针刺能有效改善PSI患者的睡眠质量、神经功能受损程度、疲劳程度,其作用机制可能与调节血清炎症因子、神经递质水平及神经兴奋性/抑制性平衡有关。
Abstract:
Objective:To observe the clinical efficacy of fire needle moxibustion combined with acupuncture in the treatment of post-stroke insomnia(PSI).Methods:70 patients with PSI were randomized into observation and control groups of 35 patients.On the basis of western basic treatment and conventional rehabilitation training,the control group was treated with conventional acupuncture.The observation group was treated with fire needle moxibustion based on the treatment of the control group.Both groups were treated once every other day,three times a week for 4 weeks.Pittsburgh Sleep Quality Index,National Institutes of Health Stroke Scale,Insomnia Severity Index Index, and Fatigue Assessment Scale(FAS)scores were assessed before and after treatment.Levels of IL-1β,IL-2,PCT,Glu and GABA and glutamate Glu/GABA ratio were measured before and after treatment,and efficacy and safety were assessed.Results:PSQI,NIHSS,ISI and FAS scores decreased in both groups(all P<0.05),IL-1β,IL-2,PCT,Glu levels and Glu/GABA ratio all decreased(all P<0.05),GABA level increased(all P<0.05),and decreases/increases were more pronounced in the observation observation group(all P<0.05).The overall efficacy in the observation group was 91.43%,significantly higher than in the control group(77.14%)(P<0.05).During the treatment period,no adverse reactions occurred in both groups.Conclusion:Fire needle tempering and moxibustion combined with acupuncture can effectively improve the sleep quality,the degree of impaired neurological function,and the degree of fatigue in PSI patients,and its mechanism of action may be related to the regulation of serum inflammatory factors,neurotransmitter levels,and the balance of neural excitability/inhibitability.

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备注/Memo

备注/Memo:
[基金项目]国家优势专科老年病科建设项目[国中医药医政函(2024)90号]; 安徽省自然科学基金资助项目(2208085MH273); 安徽省中医药传承创新科研项目(2024CCCX004); 安徽省华佗中医药研究院科技重大专项“揭榜挂帅”项目(BZKZ2402)
更新日期/Last Update: 2025-04-08