[1]杨冰祎,曾薇薇,陆齐天,等.紫萸方联合地屈孕酮治疗多囊卵巢综合征所致月经失调临床观察[J].陕西中医,2025,46(5):606-610.[doi:DOI:10.3969/j.issn.1000-7369.2025.05.006]
　YANG Bingyi,ZENG Weiwei,LU Qitian,et al.Clinical of Ziyu formula combined with dydrogesterone in treating menstrual disorders caused by polycystic ovary syndrome[J].,2025,46(5):606-610.[doi:DOI:10.3969/j.issn.1000-7369.2025.05.006]
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紫萸方联合地屈孕酮治疗多囊卵巢综合征所致月经失调临床观察
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年5期
页码:
606-610
栏目:
临床研究
出版日期:
2025-05-05

文章信息/Info

Title:
Clinical of Ziyu formula combined with dydrogesterone in treating menstrual disorders caused by polycystic ovary syndrome
作者:
杨冰祎; 曾薇薇; 陆齐天; 周一辰; 于晟贇; 陈欣敏; 殷岫绮
(上海中医药大学附属曙光医院妇产科,上海 200021)
Author(s):
YANG Bingyi; ZENG Weiwei; LU Qitian; ZHOU Yichen; YU Shengyun; CHEN Xinmin; YIN Xiuqi
(Department of Obstetrics and Gynecology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China)
关键词:
多囊卵巢综合征;  月经失调;  紫萸方;  地屈孕酮;  性激素;  抑郁焦虑状态
Keywords:
Polycystic ovary syndrome;  Menstrual disorder;  Ziyu formula;  Dydrogesterone;  Sex hormones;  Depression anxiety status
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.05.006
文献标志码:
A
摘要:
目的:观察紫萸方联合地屈孕酮治疗多囊卵巢综合征(PCOS)所致月经失调患者的临床疗效。方法:将84例PCOS患者随机分为治疗组与对照组。两组均予地屈孕酮片,治疗组予紫萸方颗粒剂,对照组予安慰颗粒剂。两组均治疗3个月经周期。比较两组患者停药后3个月平均月经周期天数及治疗前平均月经周期天数,性激素,抗苗勒氏管激素(AMH)水平、胰岛素抵抗指数(HOMA-IR),焦虑评分、抑郁评分及中医证候评分。结果:治疗后治疗组的总有效率为88.1%,高于对照组的71.4%(P<0.05)。治疗后,两组的月经周期均有所缩短,且治疗组较对照组更趋近正常周期(P<0.05)。治疗后两组的黄体生成素、AMH、睾酮水平、焦虑及抑郁评分、中医证候总积分均降低,且治疗组更低于对照组(均P<0.05),但两组的促卵泡生成素组间及组内差异均无统计学意义(P>0.05)。治疗后两组的HOMA-IR水平均较治疗前降低(P<0.05),两组间比较无统计学意义(P>0.05)。结论:紫萸方联合地屈孕酮治疗PCOS所致月经失调效果较佳,能有效调节患者的激素水平,促进并维持月经周期的正常化,同时减轻胰岛素抵抗,改善患者的情绪状态,可考虑将其作为PCOS的慢性病管理策略中在临床中应用。
Abstract:
Objective:To assess the clinical effectiveness of Ziyu formula in combination with dydrogesterone for treating menstrual irregularities induced by polycystic ovary syndrome(PCOS).Methods:84 patients diagnosed with PCOS were randomly divided into two group,namely an experimental group and a control group.Dydrogesterone tablets were provided to both groups.Additionally,the experimental group received Ziyu formula granules,while the control group was given placebo granules instead.Both groups were treated for three menstrual cycles.The average menstrual cycle length after discontinuation of medication and before treatment,levels of sex hormones,anti-Mullerian hormone(AMH),insulin resistance index,and scores of anxiety,depression,and traditional Chinese medicine(TCM)symptoms were contrasted between the two groups.Results:After treatment,the total effective rate in the treatment group was 88.1%,which was higher than 71.4% in the control group(P<0.05).After treatment,the menstrual cycles of both groups were shortened,and the menstrual cycle in the treatment group was closer to the normal cycle than that in the control group(P<0.05).After treatment,the levels of luteinizing hormone,AMH,testosterone,as well as the scores of anxiety and depression,and the total scores of traditional Chinese medicine syndromes in both groups were all decreased,and those in the treatment group were even lower than those in the control group(all P<0.05).However,there was no statistically significant difference in the levels of follicle-stimulating hormone either between the two groups or within each group(P>0.05).After treatment,the levels of the homeostasis model assessment of insulin resistance(HOMA-IR)in both groups were lower than those before treatment(P<0.05),but there was still no statistically significant difference between the two groups(P>0.05).Conclusion:The combination of Ziyu formula and dydrogesterone in treating menstrual disorders caused by PCOS is effective,can effectively regulate hormone levels,promote and maintain the normalization of menstrual cycles,reduce insulin resistance,and improve patients' emotional states.It can be considered for promotion and application in the clinical management strategy for chronic PCOS.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(82004398); 上海市卫生健康委员会科研项目(20214Y0383); 上海市卫生健康委员会中医药科研项目(2020LQ009)
更新日期/Last Update: 2025-05-08