[1]范祥玲,刘剑,宁小菊,等.基于“正邪理论”探讨胃癌分期论治[J].陕西中医,2025,46(6):809-812.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.018]
 FAN Xiangling,LIU Jian,NING Xiaoju,et al.The treatment of gastric cancer based on the theory of zheng and xie[J].,2025,46(6):809-812.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.018]
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基于“正邪理论”探讨胃癌分期论治
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
809-812
栏目:
学术探讨
出版日期:
2025-06-05

文章信息/Info

Title:
The treatment of gastric cancer based on the theory of zheng and xie
作者:
范祥玲1刘剑2宁小菊3张怡4于明薇4刘航1王晚晴1张丽娟3朱莉莉3
(1.宁夏医科大学中医学院,宁夏 银川 750001;2.宁夏医科大学总医院,宁夏 银川 750001;3.宁夏中医医院暨中医研究院,宁夏 银川 750021;4.首都医科大学附属北京中医医院,北京 100010)
Author(s):
FAN Xiangling1LIU Jian2NING Xiaoju3ZHANG Yi4YU Mingwei4LIU Hang1WANG Wanqing1ZHANG Lijuan3ZHU Lili3
(1.School of Traditional Chinese Medicine,Ningxia Medical University,Yinchuan 750001,China;2.General Hospital of Ningxia Medical University,Yinchuan 750001,China;3.Ningxia Hospital of Traditional Chinese Medicine and Institute of Traditional Chinese Medicine,Yinchuan 750021,China;4.Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
关键词:
胃癌病机正邪理论失衡理论扶正祛邪
Keywords:
Gastric cancerPathogenesisTheory of zhengqi and xieqiImbalance theoryStrengthening vital qi to eliminate pathogenic factor
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.018
文献标志码:
A
摘要:
“正邪理论”是中医基础理论体系的重要部分。“正”“邪”对立制约,二者的盛衰变化影响疾病的发生发展及预后,早期以邪盛正不虚为主,中期以邪盛正虚为主,晚期以邪不盛正虚为主。“胃为阳腑,喜润恶燥”,根据胃的生理特点,正邪相争的三阶段及宁夏地区饮食习惯、发病规律,对胃癌进行分期治疗,构建胃癌“三联方”。提出胃癌前病变、早期胃癌,攻邪以祛邪外出,以“软坚平瘤方”加减;中晚期胃癌提出中西医结合治疗,以西医祛邪为主,中医调节平衡为辅,以“强肾健脾方”加减;终末期胃癌以“扶正”为主,辅以祛邪,以“益气养阴消积方”为主。
Abstract:
The theory of “zheng and xie” is an important part of the basic theoretical system of traditional Chinese medicine.“Zheng” and “xie” are in an antagonistic and restrictive relationship.The changes in their prosperity and decline affect the occurrence,development,and prognosis of diseases.In the early stage,xie is exuberant while zheng is not deficient.In the middle stage,xie is exuberant and zheng is deficient.In the late stage,xie is not exuberant but zheng is deficient.The stomach is a yang-organ and prefers moistness and dislikes dryness.Based on the physiological characteristics of the stomach,the three stages of the struggle between zheng and xie,as well as the dietary habits and disease-onset patterns in Ningxia region,gastric cancer is treated in stages,and the “Tri-prescription for gastric cancer” is constructed.For precancerous lesions of gastric cancer and early-stage gastric cancer,the treatment is to expel xie by attacking it,with modifications of the “Ruanjian pingliu prescription”.For middle-and late-stage gastric cancer,an integrated Chinese and western medicine treatment is proposed,with western medicine mainly used to expel xie and traditional Chinese medicine used to regulate balance,with modifications of the “Qiangshen jianpi prescription”.For end-stage gastric cancer,the treatment focuses on “strengthening zheng” supplemented by expelling xie,mainly using the “Yiqi Yangyin Xiaoji prescription”.

参考文献/References:

[1]陈红男,张思若,段宝军,等.晚期胃癌患者血清miR-191、miR-425表达水平与XELOX化疗敏感性的关系[J].保健医学研究与实践,2024,21(10):93-98.
[2]王裕新,潘凯枫,李文庆.2022全球癌症统计报告解读[J].肿瘤综合治疗电子杂志,2024,10(3):1-16.
[3]CORREA P,HAENSZEL W,CUELLO C,et al.A model for gastric cancer epidemiology[J].Lancet,1975,306(7924):58-60.
[4]田松林,郑珂.多层螺旋CT联合超声造影对中晚期胃癌化疗疗效评估的价值分析[J].罕少疾病杂志,2024,31(6):84-86.
[5]杨森杰,朱景利,邓海霞,等.陈更新治疗胃癌癌前病变经验[J].国际中医中药杂志,2020,42(12):1165.
[6]EUSEBI L H,TELESE A,MARASCO G,et al.Gastric cancer prevention strategies:A global perspective[J].J Gastroenterol Hepatology,2020,35(9):1495-1502.
[7]封慧,叶柏.中医药治疗胃癌癌前病变的临床与实验研究进展[J].陕西中医,2014,10(1):106-111.
[8]杨靖芸,谢家诚,马晓聪,等.胃癌相关信号通路的中药调控研究进展[J].中国实验方剂学杂志,2023,29(16):217-228.
[9]李传,翁顺珠.中医药序贯治疗对Ⅲ/Ⅳ期胃癌患者生存期及生活质量的影响[J].深圳中西医结合杂志,2024,34(11):45-48.
[10]张晴晴,吴迪,王奕晨,等.中医药治疗胃癌前病变近20年疗效评价指标分析[J].天津中医药大学学报,2024,43(4):325-332.
[11]曾静,李明,王雄,等.幽门螺杆菌感染慢性萎缩性胃炎患者中医辨证分型特点与癌前病变风险的关系[J].四川中医,2022,40(3):60-63.
[12]王垂杰,姜树民.胃癌癌前病变与脾虚胃热气滞血瘀的关系[J].辽宁中医杂志,1997,18(12):14-15.
[13]韩慧,袁红霞.善胃Ⅰ号方对血瘀热毒型胃癌前病变PCNA的影响[J].辽宁中医杂志,2013,40(1):87-88.
[14]曾丽金.472例原发性胃癌中医证型及其相关因素的研究[D].南宁:广西中医药大学,2017.
[15]王颖,薛静辉,张姝媗,等.进展期胃癌中医证型的临床研究进展[J].癌症进展,2022,20(17):1747-1748,1752.
[16]刘琳瑞,冯剑.健脾养胃方联合信迪利单抗对中晚期胃癌脾胃虚弱证患者的临床疗效分析[J].临床研究,2024,32(10):107-111.
[17]于洁.郁仁存老师学术思想、经验总结及健脾补肾法在肿瘤治疗中的应用[D].北京:北京中医药大学,2011.
[18]陈舲,李鑫,韩慧,等.基于多元统计方法的终末期肿瘤证素特征探析[J].时珍国医国药,2019,30(2):487-489.
[19]叶艺兰,王志红,刘建祥,等.败酱草总皂苷含药血清对人胃癌SGC-7901细胞增殖的影响及机制研究[J].中国实验诊断学,2022,26(9):1380-1384.
[20]李媛媛,宫小勇,晁旭,等.白蔹的化学成分、质量控制及药理作用研究进展[J].沈阳药科大学学报,2020,37(10):956-960.
[21]李梦琦,石玉,杨诗宇,等.夏枯草抗肿瘤活性成分及其作用机制研究进展[J].中国现代应用药学,2024,41(5):716-726.
[22]于俊保,朱佳源,梅文亚,等.枳壳及其活性成分调节胃肠动力作用机制研究进展[J].中国实验方剂学杂志,2024,30(10):290-298.
[23]朱玉虎.从脾肾论治胃癌[J].新疆中医药,2018,36(3):69-71.
[24]李加葵,田劭丹,李佩文.名中医李佩文基于脾肾同调治疗胃癌经验[J].陕西中医,2023,44(9):1281-1284.
[25]刘瑜,张蕊,蒋喆,等.健脾益肾法为基础对改善晚期胃癌化疗患者生存作用的临床研究[J].陕西中医药大学学报,2024,47(1):80-84.
[26]周林.阿帕替尼联合替吉奥及一贯煎合六君子汤对气阴两虚型晚期胃腺癌的临床研究[D].合肥:安徽中医药大学,2020.
[27]庞小坤,韩梅,江心灿,等.当归补血汤治疗肿瘤化疗不良反应随机对照临床试验的Meta分析[J].医学信息,2019,32(2):69-74.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82104949);宁夏回族自治区重点研发计划项目(2024BEG02022);宁夏自然科学基金资助项目(2022AAC03416);北京市落实中央引导地方科技发展专项(Z191100008319006)
更新日期/Last Update: 2025-06-09