[1]杜玉双,罗磊,韩博闻,等.基于“肠道-微生物群-肝脏”轴探讨中药调节肠道菌群治疗非酒精性脂肪性肝病研究进展[J].陕西中医,2025,46(6):857-860.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.029]
 DU Yushuang,LUO Lei,HAN Bowen,et al.Research progress on the regulation of gut microbiota by traditional Chinese medicine to treat non-alcoholic fatty liver disease based on the “gut-microbiota-liver” axis[J].,2025,46(6):857-860.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.029]
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基于“肠道-微生物群-肝脏”轴探讨中药调节肠道菌群治疗非酒精性脂肪性肝病研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
857-860
栏目:
综 述
出版日期:
2025-06-05

文章信息/Info

Title:
Research progress on the regulation of gut microbiota by traditional Chinese medicine to treat non-alcoholic fatty liver disease based on the “gut-microbiota-liver” axis
作者:
杜玉双1罗磊2韩博闻2秦浩杰2路一诺2党中勤2
(1.河南中医药大学,河南 郑州 450008;2.河南省中医院,河南 郑州 450002)
Author(s):
DU Yushuang 1 LUO Lei 2 HAN Bowen 2 QIN Haojie 2 LU Yinuo 2 DANG Zhongqin 2
(1.Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China;2.Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)
关键词:
非酒精性脂肪性肝病肠道菌群“肠道-微生物群-肝脏”轴肝郁脾虚痰湿内停
Keywords:
Non-alcoholic fatty liver diseaseIntestinal flora“Gut-microbiota-liver” axisLiver qi stagnation and spleen deficiencyPhlegm and dampness retention
分类号:
R 575.5
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.029
文献标志码:
A
摘要:
非酒精性脂肪性肝病(NAFLD)是全球最普遍的慢性肝病,其发病率逐渐增加。近年来,肠道菌群与NAFLD发生、进展和治疗的研究取得了许多重要的进展,为NAFLD的治疗开辟了新的视角。中药成分复杂、靶点范围广,被广泛用于NAFLD的防治。目前较多的研究是关于中医药调节肠道菌群及代谢产物通过不同作用机制对NAFLD的影响。然而,中药对不同证型NAFLD肠道菌群的整理相对较少。因此,本文基于“肠道-微生物群-肝脏”轴,对不同功效的中药复方、单味中药、中药单体分别对肝郁脾虚证、痰湿内停证、湿热内蕴证、痰瘀互结证NAFLD肠道菌群的影响进行综述,以期为NAFLD的治疗以及后续机制研究提供思路。
Abstract:
Non-alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease globally,with its incidence gradually increasing.In recent years,research on the relationship between gut microbiota and the occurrence,progression,and treatment of NAFLD has made many important advances,opening up a new perspective for the treatment of NAFLD.Traditional Chinese medicine (TCM) has complex components and a broad range of targets,and it is widely used for the prevention and treatment of NAFLD.Currently,a substantial amount of research focuses on how TCM regulates the gut microbiota and its metabolites,and the various mechanisms through which these actions influence NAFLD.However,the organization of gut microbiota in different syndrome types of NAFLD by TCM is relatively limited.Therefore,based on the “gut-microbiota-liver” axis,this article reviews the effects of TCM formulas with different therapeutic effects,individual TCM herbs,and TCM monomers on the gut microbiota of NAFLD patients with different TCM syndromes,including liver qi stagnation and spleen deficiency,phlegm and dampness retention,damp-heat accumulation,and phlegm and blood stasis intermingling.It is hoped that this review will provide insights for the treatment of NAFLD and for further mechanistic studies.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82305074);全国名老中医药专家传承工作室建设项目[国中医药人教函(2022)75号];河南省中医药科学研究专项课题(2023ZY2062)
更新日期/Last Update: 2025-06-09