[1]王俊龙,刘爱峰,张超,等.基于IL-1β/p38MAPK信号通路探讨温针灸治疗膝骨关节炎作用机制[J].陕西中医,2025,46(6):861-864.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.030]
　WANG Junlong,LIU Aifeng,ZHANG Chao,et al.Mechanism of action on Needle Warming Moxibustion therapy for knee osteoarthritis based on IL-1β/p38MAPK signaling pathway[J].,2025,46(6):861-864.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.030]
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基于IL-1β/p38MAPK信号通路探讨温针灸治疗膝骨关节炎作用机制
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
861-864
栏目:
综 述
出版日期:
2025-06-05

文章信息/Info

Title:
Mechanism of action on Needle Warming Moxibustion therapy for knee osteoarthritis based on IL-1β/p38MAPK signaling pathway
作者:
王俊龙; 刘爱峰; 张超; 李远栋; 张晓宇; 张良; 崔庆同
（天津中医药大学第一附属医院 国家中医药管理局区域中医骨伤科诊疗中心 国家中医针灸临床医学研究中心，天津300381）
Author(s):
WANG Junlong; LIU Aifeng; ZHANG Chao; LI Yuandong; ZHANG Xiaoyu; ZHANG Liang; CUI Qingtong
（National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Regional Traditional Chinese Medicine Bone Injury Diagnosis and Treatment Center of State Administration of Traditional Chinese Medicine,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China）
关键词:
膝骨关节炎; 温针灸; 白细胞介素-1β; p38MAPK信号通路; 作用机制
Keywords:
Knee osteoarthritis; Needle warming moxibustion; Interleukin-1β; p38MAPK signaling pathway; Mechanism
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.030
文献标志码:
A
摘要:
膝骨关节炎（KOA）是一种以关节软骨进行性退变和关节炎症为病理特征的慢性关节疾病，其发病与年龄、关节力学失稳及过度机械负荷三个主要因素有关，早期主要表现为受累关节不同程度的肿痛、活动受限，严重影响患者的工作和生活，给个人和社会带来了沉重的经济负担，KOA的发病机制目前还不完全清楚，但与生物学因素密切相关，其中炎症信号通路的激活起到关键作用。以往的研究认为IL-1β/p38MAPK信号通路是早期KOA炎性信号通路的研究热点，该信号通路不仅可以调控软骨细胞的退变、凋亡及降解，还能逆向调控关节微环境中的炎性反应，在KOA的病理发展过程中起着至关重要的作用。综述近5年温针灸通过调控IL-1β/p38MAPK信号通路治疗KOA的成果，进一步为临床运用温针灸治疗KOA提供相关基础研究依据。
Abstract:
Knee osteoarthritis (KOA) is a chronic joint disease characterized by progressive degeneration of articular cartilage and joint inflammation,and its onset is related to three main factors:age,joint mechanical instability and excessive mechanical load.The activation of inflammatory signaling pathways plays a key role.Previous studies have suggested that the IL-1β/p38MAPK signaling pathway is a research hotspot in the early stage of KOA inflammatory signaling pathway,which can not only regulate the degeneration,apoptosis and degradation of chondrocytes,but also reverse regulate the inflammatory response in the joint microenvironment,which plays a vital role in the pathological development of KOA.This paper reviews the results of warm acupuncture in the treatment of KOA by regulating the IL-1β/p38MAPK signaling pathway in the past five years,and further provides relevant basic research basis for the clinical application of warm acupuncture in the treatment of KOA.

参考文献/References:

[1]PALMER J,GETGOOD A,LOBENHOFFER P,et al.Medial opening wedge high tibial osteotomy for the treatment of medial unicompartmental knee osteoarthritis:A state of the art review[J].J ISAKOS,2024,9(1):39-52.
[2]XIN D,ZI Y L,XING X T,et al.Research progress on the pathogenesis of knee osteoarthritis[J].Orthop Surg,2023,15(9):2213-2224.
[3]罗江淼,如斯坦木,阿特尔,等.骨关节炎发病机制及治疗研究进展[J].陕西医学杂志,2024,53(7):1006-1009.
[4]何强,梅杰,孙欣.膝骨关节炎发病及临床症状发展与中医体质类型相关性分析[J].中国中医骨伤科杂志,2023,31(10):23-28.
[5]FRANK M,BWEMERO J,KALUNGA D,et al.OA60 public health and palliative care mix;a ccpmedicine approach to reverse the overgrowing burden of non-communicable diseases in tanzania[J].BMJ Support Palliat Care,2015,5:19.
[6]巴热娜·萨布尔江,李汶阳.针灸治疗膝骨性关节炎的临床研究进展[J].新疆中医药,2024,42(5):151-154.
[7]娄本敬,次旺,严华韬,等.膝骨关节炎相关炎性因子研究进展[J].风湿病与关节炎,2024,13(2):67-71.
[8]童磊,贾锋,范丽，等.膝关节滑液白细胞介素1β、白细胞介素17、前列腺素E2含量与老年膝骨关节炎预后的关系研究[J].中医正骨,2022,34(1):33-36，40.
[9]陈景涛,陈有,李玉静，等.关节滑液中白细胞介素-18水平与膝骨关节炎病情的相关性分析[J].风湿病与关节炎,2023,12(3):24-28.
[10]刘璐,刘传慧,段智霞.膝关节炎患者血清RANKL、IL-17水平与疾病严重程度的关系[J].中国实用医刊,2021,48(19):16-19.
[11]宋晓磊.TNF-α、IL-17、OPG、RANKL变化与创伤性膝关节炎发生及严重程度的关系[J].实验与检验医学,2022,40(6):686-688.
[12]LAN S,YANG X,LI T,et al.Dexamethasone induces apoptosis of embryonic palatal mesenchymal cells through the GATA-6/bone morphogenetic protein-2/p38 MAPK pathway[J].J Craniofac Surg,2022,33(5):1335-1340.
[13]喻华梅,杨孝芳,陈盼碧,等.穴位埋线通过调节p38丝裂原活化蛋白激酶通路对哮喘大鼠气道上皮的影响[J].针刺研究,2024,49(1):23-29.
[14]YE J,SU C,JIANG Y,et al.Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis:A systematic evaluation and meta-analysis[J].Front Neurosci,2023,16:1098311.
[15]LI Z,DAI A,YANG M,et al.p38MAPK signaling pathway in osteoarthritis:Pathological and therapeutic aspects[J].J Inflamm Res,2022,15(3):723-734.
[16]XU Y S,MIN Z,PENG Z,et al.Cangxitongbi capsules protect the articular cartilage in the rat knee through the long non-coding RNA HOTAIR/p38MAPK pathway[J].Ann Transl Med,2022,10(1):23.
[17]杨琛,李兴勇,黄琛,等.白细胞介素类促炎因子在膝骨性关节炎发病机制中的研究进展[J].甘肃医药,2020,39(11):980-983.
[18]王迷娜,刘璐,赵洛鹏，等.膝骨关节炎炎性因子及信号通路的研究进展[J].中国骨伤,2020,33(4):388-392.
[19]MOLNAR V,MATISI V,KODVANJ I,et al.Cytokines and chemokines involved in osteoarthritis pathogenesis[J].Int J Mol Sci,2021,22(17):9208.
[20]HAN F,JIANG H,QU W,et al.KLF11 protects chondrocytes via inhibiting p38 MAPK signaling pathway[J].Eur Rev Med Pharmacol Sci,2020,24(12):6505-6516.
[21]CHOW Y Y,CHIN K Y.The role of inflammation in the pathogenesis of osteoarthritis[J].Mediators Inflamm,2020,2020(1):8293921.
[22]王象鹏,谢文鹏,毕亦飞,等.基于p38MAPK信号通路分析槲皮素保护骨性关节炎关节软骨的机制[J].中国实验方剂学杂志,2021,27(7):169-177.
[23]陈群.电针联合温针灸治疗退行性膝关节炎的疗效[J].实用中西医结合临床,2023,23(17):100-102.
[24]王艺婷,方永江,栾莎，等.针灸治疗膝关节骨性关节炎研究进展[J].中华中医药杂志,2022,37(6):3356-3358.
[25]林芯宇,张思爱,徐银环,等.艾灸治疗膝关节骨关节炎的疗效影响因素研究进展[J].针刺研究,2024,49(2):185-191.
[26]LUO X,LIU J,LI Q,et al.Acupuncture for treatment of knee osteoarthritis:A clinical practice guideline[J].J Evid Based Med,2023,16(2):237-245.
[27]METHODS I N，MEDICINE C M.Retracted:Effect of moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness knee arthritis[J].Comput Math Methods Med,2023,2023(1):9787969.
[28]夏循富,房显辉,金远林,等.温针治疗膝骨关节炎疗效观察及对关节滑液中IL-1β、TNF-α的影响[J].上海针灸杂志,2018,37(4):453-456.
[29]李益军,梁兴森,方细霞，等.温针灸对膝骨关节炎大鼠IL-1β、ADAMTS-7、MMP-3表达的影响[J].中医药通报,2023,22(6):61-65.
[30]李龙,刘君伟,王铎,等.温针灸对兔膝骨关节炎软骨组织中NLRP3、IL-1β和IL-18表达的影响[J].宁夏医科大学学报,2023,45(1):85-91.
[31]张其镇,苗雨,王大力，等．独活寄生汤配合温针灸治疗风寒湿痹型膝骨关节炎患者的疗效及对血清疼痛介质、炎症介质、白三烯的影响[J].中国实验方剂学杂志，2018,24(18):153-158．
[32]林腾飞,付爱玲,周宇.温针灸联合PRP治疗膝骨关节炎的临床疗效分析[J].实用中西医结合临床,2024,24(18):65-67.
[33]于楠.温针灸治疗膝关节骨性关节炎对患者临床疗效及JOA评分的影响[J].当代医学,2021,27(20):179-180.
[34]刘君伟,张艳玲,闻兵,等.温针灸联合骨髓间充质干细胞移植对兔膝骨关节炎的影响[J].宁夏医科大学学报,2018,40(5):517-522，532.
[35]韩燕,钱英军,张百百,等.温针灸结合火针治疗虚寒性膝骨关节病的效果[J].名医,2023,3(15):21-23.
[36]刘潘,罗催,周思佳,等.温针灸治疗膝骨关节炎的应用与机制研究进展[J].基层中医药,2024,3(3):119-124.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374489,81873316,81673994）；天津中医药大学第一附属医院“拓新工程”基金资助课题（院YB202120）
更新日期/Last Update: 2025-06-09