[1]林钰莹,陈全福.补阳还五汤联合瑞舒伐他汀治疗冠心病心绞痛疗效研究[J].陕西中医,2025,46(7):924-928.[doi:DOI:10.3969/j.issn.1000-7369.2025.07.012]
　LIN Yuying,CHEN Quanfu.Study on therapeutic effect of Buyang Huanwu decoction combined with rosuvastatin in treatment of angina pectoris in coronary heart disease[J].,2025,46(7):924-928.[doi:DOI:10.3969/j.issn.1000-7369.2025.07.012]
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补阳还五汤联合瑞舒伐他汀治疗冠心病心绞痛疗效研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年7期
页码:
924-928
栏目:
临床研究
出版日期:
2025-07-05

文章信息/Info

Title:
Study on therapeutic effect of Buyang Huanwu decoction combined with rosuvastatin in treatment of angina pectoris in coronary heart disease
作者:
林钰莹1; 陈全福2
（1.广州中医药大学，广东 广州 510499；2.广州医科大学附属中医医院，广东 广州 510655）
Author(s):
LIN Yuying1; CHEN Quanfu2
(1.Guangzhou University of Chinese Medicine,Guangzhou 510499,China；2.The Affiliated TCM Hospital of Guangzhou Medical University,Guangzhou 510655,China)
关键词:
冠心病; 心绞痛; 补阳还五汤; 瑞舒伐他汀; 血液流变学; 血脂代谢
Keywords:
Coronary heart disease; Angina pectoris; Buyang Huanwu decoction; Rosuvastatin; Hemorheology; Lipid metabolism
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7369.2025.07.012
文献标志码:
A
摘要:
目的：探究补阳还五汤联合瑞舒伐他汀治疗冠心病心绞痛疗效，以及对患者血液流变学、血脂代谢的影响。方法：选取132例冠心病心绞痛患者作为研究对象，按随机数字表法分为研究组、对照组，各66例。两组均给予常规治疗，对照组采用瑞舒伐他汀钙片治疗，研究组给予瑞舒伐他汀联合补阳还五汤治疗。治疗4周后，对比两组心绞痛发作程度、中医证候积分与发作情况、血液流变学指标、血脂代谢指标及不良反应发生情况的差异。结果：治疗后，研究组心绞痛缓解总有效率为93.94%（62/66），对照组为78.79%（52/66），研究组总有效率高于对照组（P＜0.05）。与治疗前相比，治疗 4 周后两组中医证候积分、发作持续时间、发作频率、全血低切黏度、纤维蛋白原、全血高切黏度、血浆黏度、红细胞比容、红细胞聚集指数、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）降低，且研究组低于对照组（均P＜0.05）。两组不良反应发生情况比较，差异无统计学意义（P＞0.05）。结论：补阳还五汤联合瑞舒伐他汀钙片治疗冠心病心绞痛疗效较好，可有效缓解心绞痛严重程度，降低中医证候积分与发作频率，改善血液流变学和血脂代谢，且安全性良好。
Abstract:
Objective:To investigate efficacy of Buyang Huanwu decoction combined with rosuvastatin in treating coronary heart disease(CHD) patients with angina pectoris，and its impacts on hemorheology and lipid metabolism.Methods:A total of 132 CHD patients with angina pectoris were enrolled and randomly divided into study group and control group,with 66 cases in each group.Both groups received routine treatment.The control group were treated with rosuvastatin calcium tablets,while the study group were treated with a combination of rosuvastatin and Buyang Huanwu decoction.After 4 weeks of treatment,severity of angina pectoris,scores of traditional Chinese medicine (TCM) syndromes,attack frequency,hemorheological parameters,lipid metabolism indices,and the incidence of adverse reactions were compared between the two groups.Results:After 4 weeks of treatment,the total effective rate of angina pectoris alleviation in the study group was 93.94% (62/66),significantly higher than that in the control group (78.79%,52/66)，difference statistically significant(P＜0.05).Compared with those before treatment,the TCM syndrome scores,duration and frequency of angina attacks,whole blood low-shear viscosity,fibrinogen,whole blood high-shear viscosity,plasma viscosity,hematocrit,red blood cell aggregation index,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol(LDL-C) levels in both groups were significantly decreased,and the reductions were more pronounced in the study group (all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:The combination of Buyang Huanwu decoction and rosuvastatin calcium tablets exhibits a favorable therapeutic effect on CHD patients with angina pectoris.It can effectively alleviate the severity of angina,reduce TCM syndrome scores and attack frequency,improve hemorheology and lipid metabolism,with good safety.

参考文献/References:

[1]李梦媛,曹兆流,鲍柏屹.地奥心血康联合钙通道阻滞剂治疗冠心病心绞痛患者疗效的Meta分析[J].中国循证心血管医学杂志,2023,15(7):777-780.
[2]郭瑞霞,冯永萌,姚文哲,等.麝香保心丸联合替格瑞洛治疗冠心病心绞痛的临床研究[J].现代药物与临床,2022,37(1):81-85.
[3]侯耀宗,张世亮.补阳还五汤治疗冠心病稳定型心绞痛气虚血瘀证临床观察[J].光明中医,2023,38(20):3973-3976.
[4]潘帅虎,张云飞,余志勇,等.补阳还五汤对骨科大手术后患者中医体质及深静脉血栓的影响[J].中国中医急症,2023,32(9):1611-1613.
[5]冯万立,卫建民,王自立,等.阳和汤合补阳还五汤联合经皮脊柱内镜下结核病灶清除术治疗阳虚痰凝型脊柱结核的研究[J].现代中西医结合杂志,2022,31(24):3456-3459.
[6]芦伟,刘满意,方勇.瑞舒伐他汀联合单硝酸异山梨酯片治疗冠心病心绞痛的临床疗效[J].医学综述,2023,29(15):3116-3120.
[7]葛均波,徐永健.内科学[M].北京:人民卫生出版社,2013:227-235.
[8]梁茂新,洪治平.对新版《中药新药临床研究指导原则》的若干意见[J].世界科学技术：中医药现代化,2004,6(5):40-43.
[9]盛丽,倪荣,桑盛敏,等.参麦注射液联合替格瑞洛治疗冠心病心绞痛的临床研究[J].现代药物与临床,2022,37(10):2272-2275.
[10]白艳君,叶靖,闫治全.参芎葡萄糖注射液与左卡尼汀治疗冠心病心绞痛患者的临床疗效探讨[J].贵州医药,2022,46(8):1250-1251.
[11]孙春全,谢雁鸣,侯恒悦.生脉注射液治疗冠心病心绞痛临床特征及合并用药的真实世界研究[J].世界中医药,2022,17(1):123-128.
[12]王晶,刘易婷,刘哲.替米沙坦联合瑞舒伐他汀治疗糖尿病合并冠心病对患者外周胰岛素抵抗、糖化血红蛋白、脂蛋白和心肌缺血的影响[J].陕西医学杂志,2022,51(5):595-598.
[13]徐炜堇,黄海燕,栾伟.稳心调脂汤联合瑞舒伐他汀治疗冠心病合并高脂血症临床观察[J].湖北中医药大学学报,2023,25(5):19-22.
[14]宋文婷,丁昭,苗兰,等.补阳还五汤治疗大鼠气虚血瘀型脑缺血的代谢组学研究[J].世界中医药,2023,18(15):2154-2159.
[15]辛紫媛,靳晓飞,周晓红,等.补阳还五汤对脑缺血/再灌注损伤大鼠皮质区沉默信息调节因子1表达的影响[J].中国药理学通报,2022,38(12):1896-1901.
[16]毕俊芳,许志会,戢敏,等.补阳还五汤联合艾灸对恶性肿瘤血液高凝状态的干预研究[J].现代中西医结合杂志,2022,31(13):1808-1812.
[17]王月华,杨帆,马赟,等.补阳还五汤合参芪地黄汤化裁对Ⅲ-Ⅳ期糖尿病肾病的临床疗效及肾小管损伤的保护作用[J].中草药,2023,54(16):5289-5295.
[18]靳丹,罗世杰,马艳芳,等.补阳还五汤联合西药治疗小儿过敏性紫癜性肾炎的疗效及对机体血管内皮功能的影响研究[J].现代生物医学进展,2023,23(16):3083-3087.
[19]梁春玲,陈晓杰,刘祖发,等.补阳还五汤联合西药治疗急性脑梗死疗效及对患者血管斑块稳定性及血清因子水平的影响[J].陕西中医,2020,41(9):1200-1204.
[20]江六顺,汪瑛,陈少飞,等.通督调神针法联合补阳还五汤治疗卒中偏瘫的临床疗效观察[J].中华中医药学刊,2023,41(5):206-208.
[21]刘娜,张纪元.比索洛尔联合瑞舒伐他汀治疗急性心肌梗死的疗效观察[J].贵州医药,2022,46(4):533-534.
[22]张扬,严寒,梁永.补阳还五汤对缺血性脑卒中大鼠认知功能的影响[J].中成药,2023,45(4):1309-1314.
[23]李娟,王静依,周欣欣,等.补阳还五汤黄芪不同配比组方调控平滑肌细胞增殖及迁移抑制动脉粥样硬化的分子机制[J].中华中医药学刊,2023,41(11):138-142.
[24]王静依,李娟,周欣欣,等.补阳还五汤黄芪不同配比组方通过ROCK信号通路抑制动脉粥样硬化的机制研究[J].时珍国医国药,2024,35(1):30-34.
[25]常亮,杨蓉,刘素云,等.RhoA/ROCK-NFκB信号传导通路在内脂素引起心肌细胞肥大中的作用[J].河北医药,2022,44(12):1799-1803.
[26]李霞,邸亚丽,亢小丽,等.阿托伐他汀对氧化型低密度脂蛋白诱导内皮细胞损伤的保护作用[J].中国临床药理学杂志,2021,37(10):1184-1188.

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备注/Memo

备注/Memo:
广东省中医药局科研项目（20231157）
更新日期/Last Update: 2025-07-09