[1]李玎玎,何丹迪,王金环.基于“虫子学说”探讨中医药对再生障碍性贫血免疫调控的研究进展[J].陕西中医,2025,46(8):1136-1140.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.026]
　LI Dingding,HE Dandi,WANG Jinhuan.Exploring the research progress of traditional Chinese medicine on immune regulation of aplastic anemia from insect theories[J].,2025,46(8):1136-1140.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.026]
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基于“虫子学说”探讨中医药对再生障碍性贫血免疫调控的研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年8期
页码:
1136-1140
栏目:
综 述
出版日期:
2025-08-05

文章信息/Info

Title:
Exploring the research progress of traditional Chinese medicine on immune regulation of aplastic anemia from insect theories
作者:
李玎玎1; 何丹迪1; 王金环2
（1.黑龙江中医药大学，黑龙江 哈尔滨 150040；2.黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040）
Author(s):
LI Dingding1; HE Dandi1; WANG Jinhuan2
（1.Heilongjiang University of Chinese Medicine，Harbin 150040,China;2.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China）
关键词:
再生障碍性贫血; 中医药; 免疫; 细胞因子; 信号通路; 虫子学说
Keywords:
Aplastic anemia; Traditional Chinese medicine; Immunity; Cytokine; Signaling pathway; Insect theories
分类号:
R 556.5
DOI:
DOI:10.3969/j.issn.1000-7369.2025.08.026
文献标志码:
A
摘要:
再生障碍性贫血（AA）是由多因素引起的骨髓造血功能减低或衰竭的血液系统疾病。AA经典发病机制与“虫子学说”密切相关，即免疫异常。多种免疫调节药物治疗AA有良好的临床疗效，说明免疫介导的造血抑制是AA发病原因之一。目前，中医药治疗AA多从干预造血细胞、改善骨髓微环境等方面探索，从免疫机制方面干预AA的研究较少。本文对近年来中医药调控免疫细胞、细胞因子和信号通路等方面治疗AA的文献进行综述，为今后深入研究AA发病机制与新治疗靶点提供证据和思路。
Abstract:
Aplastic anemia (AA) is a hematopathy caused by reduction or failure of bone marrow hematopoietic function caused by multiple factors.The classic pathogenesis of aplastic anemia (AA) can not be separated from the “insect theories”,which refers to immune abnormalities.Various immunomodulatory drugs have demonstrated good clinical efficacy in the treatment of AA,further confirming that immune-mediated suppression of hematopoiesis is one of the causes of AA.However,current studies on TCM treatment for AA mostly focus on intervening in hematopoietic cells and improving the bone marrow microenvironment,with fewer studies exploring interventions from the perspective of immune mechanisms.This article reviews recent reports on the treatment of AA with traditional Chinese medicine in recent years by regulating immune cells,cytokines,and signaling pathways.And provide evidence and ideas for further research on the pathogenesis and new therapeutic targets of AA.

参考文献/References:

[1]蒲有为,胡雪,罗金莲,等.中医药治疗再生障碍性贫血的研究进展[J].临床输血与检验,2024,26(5):715-720.
[2]陆嘉惠,周永明,胡明辉.健脾补肾活血方药对再生障碍性贫血小鼠CTL介导的造血抑制因子影响[J].医学综述,2007,13(23):1900-1902.
[3]董杰,靳玉凤,贾燕.升血灵胶囊联合ALG/ATG和CSA治疗重型再生障碍性贫血的疗效[J].热带医学杂志,2019,19(11):1389-1391，1424.
[4]张伟,乔保亚,孙艳.熟萸养血汤对非重型再生障碍性贫血患者的免疫功能的影响[J].环球中医药,2024,17(4):716-719.
[5]DENG P,LI X,WEI Y,et al.The herbal decoction modified Danggui Buxue Tang attenuates immune-mediated bone marrow failure by regulating the differentiation of T lymphocytes in an immune-induced aplastic anemia mouse model[J].PLoS One,2017,12(7):e180417.
[6]LIU Z,CHEN L,XIONG D,et al.Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway[J].Redox Rep,2023,28(1):2225868.
[7]王德好,王文儒,谌海燕,等.再障膏方对再生障碍性贫血小鼠免疫细胞及脾脏形态和功能的影响[J].现代中西医结合杂志,2021,30(33):3677-3682.
[8]陆颖佳,赵琳,陈珮,等.复方参鹿颗粒联合西药对肾阳虚证再生障碍性贫血患者Treg细胞及细胞因子的影响[J].中成药,2018,40(8):1705-1710.
[9]黄中迪,邱振伟.复方参鹿颗粒对肾阳虚型再生障碍性贫血患者外周血Treg/Th17水平及其基因转录因子影响的临床观察[J].上海中医药杂志,2017,51(8):58-61.
[10]黄中迪,田华捷,封舟,等.“补肾活血方”治疗慢性再生障碍性贫血的临床疗效及其免疫机制研究[J].江苏中医药,2024,56(8):32-36.
[11]李雪,韦翊,邓培颖,等.补肾生血解毒方对免疫介导的再生障碍性贫血小鼠淋巴细胞分化及血液学参数的影响[J].北京中医药大学学报,2017,40(10):833-838.
[12]LIU H,ZHANG T,CHEN Y,et al.Proteomics analysis reveals alterations of NK cells in patients with severe aplastic anemia[J].Int J Lab Hematol,2020,42(3):308-315.
[13]向立丽,马家乐,蒙延娜,等.自拟健脾养肾补血汤辅助治疗再生障碍性贫血的疗效及对免疫功能、血清miR-155-5p、miR-1260b的影响[J].四川中医,2024,42(3):88-92.
[14]冯辉.人参皂苷Rb1对免疫介导再生障碍性贫血小鼠造血功能及成熟树突状细胞数量的影响[D].杭州：浙江中医药大学,2016.
[15]陈姗姗.三七总皂苷调节再生障碍性贫血造血及免疫功能的机制研究[D].广州:南方医科大学,2022.
[16]刘虹伶,王美佳,晏青霞.多发性骨髓瘤患者血清β2-微球蛋白、肿瘤坏死因子-α、乳酸脱氢酶检测及临床意义[J].陕西医学杂志,2024,53(3):399-402.
[17]JIN X,DAI G,XUAN L,et al.Effects of sodium chlorophyllin copper on APO-1 expression in bone marrow mesenchymal stem cells of rats with aplastic anaemia[J].J Immunol Res,2022,2022(1):6792866.
[18]ZHOU J,LI X,DENG P,et al.Chinese herbal formula,modified Danggui Buxue Tang,attenuates apoptosis of hematopoietic stem cells in immune-mediated aplastic anemia mouse model[J].J Immunol Res,2017,2017(1):9786972.
[19]杨桐,田春洪,田原,等.益血生髓颗粒对苯试剂诱导的再生障碍性贫血小鼠造血功能及T细胞亚群的影响[J].陕西中医,2022,43(8):1019-1023.
[20]何昊兰,鲁英娟,张小莉,等.健脾生血汤联合促红素治疗再生障碍性贫血疗效及对患者中医症候、炎症因子水平的影响[J].陕西中医,2022,43(10):1411-1413，1418.
[21]胡明辉,周永明,朱文伟,等.健脾补肾活血方对再生障碍性贫血患者骨髓造血细胞Fas及FasL影响[J].福建中医药,2007,38(2):9-10.
[22]郭剑锋.血复生对CAA患者Fas/FasL介导的骨髓单个核细胞凋亡的影响[D].南京:南京中医药大学,2009.
[23]ZHANG Z,WANG H,YUAN J,et al.Design,synthesis,and pharmacological evaluation of sinomenine derivatives on rings A and C:Novel compounds screening for aplastic anemia targeting on cytotoxic T lymphocyte[J].Eur J Med Chem,2021,225:113791.
[24]张乐.穿龙薯蓣皂苷通过HIF-1α/NF-κB通路治疗再生障碍性贫血的机制研究[D].天津:天津医科大学,2019.
[25]LI H,JI L,SHEN Y,et al.Bushen Jianpi Quyu formula alleviates myelosuppression of an immune-mediated aplastic anemia mouse model via inhibiting expression of the PI3K/AKT/NF-κB signaling pathway[J].Evid Based Complement Alternat Med,2022,2022(1):9033297.
[26]杜青,何丹,黄建华,等.四物膏对再生障碍性贫血模型大鼠骨髓造血功能的影响[J].中国实验方剂学杂志,2021,27(3):92-98.
[27]李锦,华海应,高华强,等.补肾健脾化瘀中药对难治/复发再生障碍性贫血患者骨髓CD3+T淋巴细胞内p-mTOR、p-S6、IFN-γ表达的影响[J].西部中医药,2022,35(9):4-9.
[28]BEURET L,FORTIER-BEAULIEU S P,Rondeau V,et al.Mek1 and Mek2 functional redundancy in erythropoiesis[J].Front Cell Dev Biol,2021,9:639022.
[29]张爱萍,高瑞兰,尹利明,等.人参二醇组皂苷对再生障碍性贫血小鼠造血组织MAPK/ERK信号通路的诱导作用[J].中国病理生理杂志,2018,34(4):686-692.
[30]张珊.基于Notch信号通路探讨穿龙薯蓣皂苷治疗再生障碍性贫血疗效及机制研究[D].天津:天津医科大学,2019.

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[10]唐洪屈,刘 娜△,刘 勇,等.从脾肾论治熟地黄在慢性再生障碍性贫血治疗中的应用*[J].陕西中医,2020,(6):780.[doi:DOI:10.3969/j.issn.10007369.2020.06.022]

备注/Memo

备注/Memo:
国家自然科学基金资助项目（82474490）；黑龙江省重点研发计划项目（2023ZX06C15）
更新日期/Last Update: 2025-08-08