[1]罗宇,杨靖芸,谢家诚,等.中药干预PI3K/Akt信号通路调控消化道肿瘤作用机制研究进展[J].陕西中医,2025,46(8):1141-1145.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.027]
　LUO Yu,YANG Jingyun,XIE Jiacheng,et al.Research progress on the mechanism of intervention in the PI3K/Akt signaling pathway regulating traditional Chinese medicine digestive tract tumors[J].,2025,46(8):1141-1145.[doi:DOI:10.3969/j.issn.1000-7369.2025.08.027]
点击复制

中药干预PI3K/Akt信号通路调控消化道肿瘤作用机制研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年8期
页码:
1141-1145
栏目:
综 述
出版日期:
2025-08-05

文章信息/Info

Title:
Research progress on the mechanism of intervention in the PI3K/Akt signaling pathway regulating traditional Chinese medicine digestive tract tumors
作者:
罗宇1; 杨靖芸2; 谢家诚3; 崔引航4; 马晓聪5; 罗伟生4
（1.广西中医药大学研究生院，广西 南宁 530001；2.广西国际壮医医院，广西 南宁 530200；3.广西中医药大学第一附属医院，广西 南宁 530012；4.广西中医药大学附属瑞康医院，广西 南宁 530011；5.广西中医药大学，广西 南宁 530200）
Author(s):
LUO Yu1; YANG Jingyun2; XIE Jiacheng3; CUI Yinhang4; MA Xiaocong5; LUO Weisheng4
(1.Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001，China;2.Guangxi International Zhuang Medicine Hospital,Nanning 530200，China;3.The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530012,China; 4.Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011，China;5.Guangxi University of Chinese medicine,Nanning 530200，China)
关键词:
消化道肿瘤; PI3K/Akt信号通路; 增殖; 侵袭; 转移
Keywords:
Digestive tract tumor; PI3K/Akt signaling pathway; Proliferation; Invasion; Transfer
分类号:
R 735
DOI:
DOI:10.3969/j.issn.1000-7369.2025.08.027
文献标志码:
A
摘要:
总结近年来中医药调控PI3K/Akt信号通路治疗消化道肿瘤的研究进展。中药单体如人参、柴胡、绞股蓝、红景天苷、人参皂苷等及复方如清胰化积汤、大柴胡汤、六味五灵片等，能够通过调控PI3K/Akt信号通路发挥抗肿瘤作用。具体机制包括下调抗凋亡蛋白（如Bcl-2、Bcl-xL）、免疫抑制因子（如IL-10、TGF-β）、侵袭与转移相关因子（如MMP-2、MMP-9、VEGF）、细胞周期相关蛋白（如Cyclin D1、CDK4/6）的表达，抑制肿瘤细胞增殖，诱导凋亡，抑制肿瘤侵袭与转移，并调节免疫应答。此外，中医药在抑制血管新生、抗肿瘤免疫调节等方面的作用也得到了证实。
Abstract:
This paper summarizes recent research on the regulation of the PI3K/Akt signaling pathway in the treatment of gastrointestinal tumors using traditional Chinese medicine (TCM).Studies have shown that TCM monomers such as ginseng,bupleurum,gynostemma,rhodiola rosea,ginsenosides,as well as formulations like Qingyi Huaji decoction,Dachaihu decoction,and Liuwei Wuling pills,can exert antitumor effects by modulating the PI3K/Akt pathway.The specific mechanisms include downregulation of anti-apoptotic proteins (Bcl-2,Bcl-xL),immune suppressive factors (IL-10,TGF-β),invasion and metastasis-related factors (MMP-2,MMP-9,VEGF),and cell cycle-related proteins (Cyclin D1,CDK4/6),thereby inhibiting tumor cell proliferation,inducing apoptosis,suppressing tumor invasion and metastasis,and modulating immune responses.Moreover,the roles of TCM in promoting angiogenesis inhibition and regulating antitumor immunity have also been confirmed.

参考文献/References:

[1]SUNG H,FERLAY J,SIEGEL R L,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
[2]ZHENG R S,CHEN R,HAN B F,et al.Cancer incidence and mortality in China,2022[J].Zhonghua Zhong Liu Za Zhi,2024,46(3):221-231.
[3]朱雅楠，袁锐，赵玉磊，等.清热凉血类中药调控PI3K/Akt/mTOR信号通路治疗银屑病研究进展[J].陕西中医,2024,45(7):999-1001.
[4]李倩宇，卢健棋，温志浩，等.基于PI3K/Akt通路探讨补阳还五汤对急性心肌梗死大鼠内皮祖细胞凋亡的影响[J].陕西中医,2023,44(7):827-832.
[5]何静子，穆其琛，付东阁，等.lncRNA TMPO-AS1通过PI3K/Akt信号通路对多囊卵巢综合征大鼠性激素和卵巢功能的影响[J].陕西医学杂志,2024,53(2):152-156.
[6]WANG J,HU K,CAI X,et al.Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis[J].Acta Pharm Sin B,2022,12(1):18-32.
[7]HE Z,XU Y,RAO Z,et al.The role of alpha7-nAChR-mediated PI3K/AKT pathway in lung cancer induced by nicotine[J].Sci Total Environ,2024,912:169604.
[8]DONG S,LIANG S,CHENG Z,et al.ROS/PI3K/Akt and Wnt/beta-catenin signalings activate HIF-1alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer[J].J Exp Clin Cancer Res,2022,41(1):15.
[9]XU R,YU J,SONG S,et al.Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling[J].Int J Med Sci,2022,19(13):1835-1846.
[10]HUANG Y,CHIU L,TSENG J,et al.Attenuation of PI3K-Akt-mTOR pathway to reduce cancer stemness on chemoresistant lung cancer cells by shikonin and synergy with BEZ235 inhibitor[J].Int J Mol Sci,2024,25(1)：616.
[11]LIANG H,YIN G,SHI G,et al.Echinacoside regulates PI3K/AKT/HIF-1α/VEGF cross signaling axis in proliferation and apoptosis of breast cancer[J].Anal Biochem,2024,684:115360.
[12]THAPA N,CHEN M,HORN H T,et al.Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4[J].Nat Cell Biol,2020,22(11):1357-1370.
[13]LUO J,SUN P,ZHANG X,et al.Canagliflozin modulates hypoxia-induced metastasis,angiogenesis and glycolysis by decreasing HIF-1α protein synthesis via AKT/mTOR pathway[J].Int J Mol Sci,2021,22(24)：13336.
[14]HAN Y,GUO S,LI Y,et al.Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NF-κB and MAPK pathway on dry eye[J].Phytomedicine,2023,121:155081.
[15]SEIDAH N G,PRAT A.The multifaceted biology of PCSK9[J].Endocr Rev,2022,43(3):558-582.
[16]WANG L,LI S,LUO H,et al.PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages[J].J Exp Clin Cancer Res,2022,41(1):303.
[17]ZHAO S,MI Y,GUAN B,et al.Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer[J].J Hematol Oncol,2020,13(1):156.
[18]SHANG L,WANG Y,LI J,et al.Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation[J].J Ethnopharmacol,2023,302(Pt A):115876.
[19]LI X,WANG S,YANG X,et al.Patrinia villosa treat colorectal cancer by activating PI3K/Akt signaling pathway[J].J Ethnopharmacol,2023,309:116264.
[20]MU B,LI Y,YE N,et al.Understanding apoptotic induction by Sargentodoxa cuneata-Patrinia villosa herb pair via PI3K/AKT/mTOR signalling in colorectal cancer cells using network pharmacology and cellular studies[J].J Ethnopharmacol,2024,319(3):117342.
[21]LIU F,LIANG Y,SUN R,et al.Astragalus mongholicus Bunge and Curcuma aromatica Salisb.inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathway[J].Chin Med,2022,17(1):91.
[22]RONG L,LI Z,LENG X,et al.Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway[J].Biomed Pharmacother,2020,122:109726.
[23]LV L,LIU B.Antitumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways[J].Mol Med Rep,2017,16(6):8977-8982.
[24]LIAO X,GAO Y,HUANG S,et al.Tanshinone ⅡA combined with cisplatin synergistically inhibits non-small-cell lung cancer in vitro and in vivo via down-regulating the phosphatidylinositol 3-kinase/Akt signalling pathway[J].Phytother Res,2019,33(9):2298-2309.
[25]SU C,CHIU T.Tanshinone ⅡA decreases the protein expression of EGFR,and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo[J].Oncol Rep,2016,36(2):1173-1179.
[26]QU L,LIU Y,DENG J,et al.Ginsenoside RK3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma[J].J Pharm Anal,2023,13(5):463-482.
[27]YUAN F,GAO Q,TANG H,et al.Ophiopogonin B targets PTP1B to inhibit the malignant progression of hepatocellular carcinoma by regulating the PI3K/AKT and AMPK signaling pathways[J].Mol Med Rep,2022,25(4):122.
[28]KONG N,CHEN X,FENG J,et al.Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1[J].Acta Pharm Sin B,2021,11(12):4045-4054.
[29]SUN L,CHEN W,ZHAO P,et al.Anticancer effects of wild baicalin on hepatocellular carcinoma:Downregulation of AKR1B10 and PI3K/AKT signaling pathways[J].Cancer Manag Res,2024,16:477-489.
[30]赵婷婷，王兆洪，林胜璋.人参皂苷Rg3通过PI3K途径抑制胰腺癌细胞上皮间质转化及血管生成拟态[J].中草药,2024,55(18):6261-6268.
[31]XU X,CUI L,ZHANG L,et al.Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer[J].Int Immunopharmacol,2023,122:110579.
[32]LIU Y,BAI Y,ZHANG J,et al.Utilizing network pharmacology and experimental validation to explore the potential molecular mechanisms of raw Pinellia ternate in treating esophageal cancer[J].J Gastrointest Oncol,2023,14(5):2006-2017.
[33]YANG Z,LIU H,SONG Y,et al.Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxelresistant esophageal squamous cell carcinoma[J].Int J Mol Med,2024,54(3):77.

相似文献/References:

[1]周帅亮,徐中菊,张佳璐,等.基于PI3K/Akt信号通路探讨健脾理气降脂汤联合肥三针治疗单纯性肥胖临床研究[J].陕西中医,2025,46(9):1278.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.026]
　ZHOU Shuailiang,XU Zhongju,ZHANG Jialu,et al.Clinical effect analysis of Jianpi Liqi Jiangzhi decoction combined with fei san acupuncture in the treatment of simple obesity[J].,2025,46(8):1278.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.026]
[2]刘佳宁,任佳杰,胡蝶,等.基于PI3 K/AKT信号通路探究中医药防治复发性流产研究进展[J].陕西中医,2025,46(9):1289.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.028]
　LIU Jianing,REN Jiajie,HU Die,et al.Explore the prevention and treatment of traditional Chinese medicine based on PI3K/AKT signaling pathway Research progress of recurrent abortion[J].,2025,46(8):1289.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.028]

备注/Memo

备注/Memo:
国家自然科学基金资助项目（82160834）；全国名老中医药专家传承工作室建设项目[国中医药人教函（2022）75号]；中西医结合广西一流学科（培育）建设项目[桂教科研（2018）12号]
更新日期/Last Update: 2025-08-08