[1]李云松,梁友情,杨荣刚,等.靳三针联合早期鼓室注射地塞米松治疗全聋型突聋疗效观察[J].陕西中医,2025,46(9):1274-1277,1283.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.025]
 LI Yunsong,LIANG Youqing,YANG Ronggang,et al.Clinical efficacy of Jin’s three-needle therapy combined with early intratympanic dexamethasone injection for total deafness-type sudden sensorineural hearing loss[J].,2025,46(9):1274-1277,1283.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.025]
点击复制

靳三针联合早期鼓室注射地塞米松治疗全聋型突聋疗效观察

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年9期
页码:
1274-1277,1283
栏目:
针灸经络
出版日期:
2025-09-05

文章信息/Info

Title:
Clinical efficacy of Jin’s three-needle therapy combined with early intratympanic dexamethasone injection for total deafness-type sudden sensorineural hearing loss
作者:
李云松1梁友情1杨荣刚1徐露1叶剑胜2
(1.贵州中医药大学第二附属医院耳鼻咽喉头颈外科,贵州 贵阳 550001;2.深圳市罗湖区人民医院,广东 深圳 518005)
Author(s):
LI Yunsong1LIANG Youqing1YANG Ronggang1XU Lu1YE Jiansheng2
(1.Department of Otolaryngology Head and Neck Surgery,Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;2.Shengzhen Luohu People’s Hospital,Shenzhen 518005,China)
关键词:
突发性感音神经性聋全聋型靳三针鼓室注射地塞米松内耳微循环
Keywords:
Sudden sensorineural hearing lossTotal deafness-typeJin’s three-needle therapyIntratympanic injectionDexamethasoneInner ear microcirculation
分类号:
R 764.43
DOI:
DOI:10.3969/j.issn.1000-7369.2025.09.025
文献标志码:
A
摘要:
目的:探究靳三针疗法联合鼓室注射地塞米松治疗全聋型突发性感音神经性聋(SSNHL)的临床疗效。方法:采用回顾性队列研究设计,纳入70例全聋型SSNHL患者(听力损失≥81 dB HL),分为观察组(35例)和对照组(35例)。观察组采用靳三针(取穴耳三针、颞三针、脑三针)联合鼓室注射地塞米松(5 mg/ml)治疗,对照组仅接受鼓室注射治疗。比较两组患者听力恢复情况、伴随症状改善程度及总体疗效。结果:观察组500、1000、2000 Hz平均听阈改善值显著优于对照组(P<0.001);观察组眩晕缓解率(72.22% 与 35.29%)和耳鸣改善率(70.37% 与40.86%)均显著高于对照组(均P<0.05),耳闷症状改善两组比较无统计学差异(P>0.05);观察组总有效率为80.00%,显著高于对照组的57.10%(P<0.05)。结论:靳三针联合鼓室注射地塞米松可通过改善内耳微循环、增强药物靶向性及神经保护等协同作用,显著提高全聋型SSNHL患者的听力恢复率和症状改善效果。该中西医结合方案为治疗难治性突发性聋提供了新思路,其具体机制有待进一步研究证实。
Abstract:
Objective:To investigate the clinical efficacy of Jin’s three-needle therapy combined with intratympanic dexamethasone injection (ITDI) in treating total deafness-type sudden sensorineural hearing loss (SSNHL).Methods:A retrospective cohort study was conducted on 70 patients with total deafness-type SSNHL (hearing loss ≥81 dB HL) were divided into an observation group (n=35,treated with Jin’s three-needle therapy targeting Ear-three-needles,Temporal-three-needles,Brain-three-needles acupoints combined with ITDI (5 mg/ml dexamethasone) and a control group (n=35,ITDI alone).Outcomes included hearing recovery,symptom improvement (vertigo,tinnitus,aural fullness),and overall efficacy.Results:The observation group showed significantly better mean threshold recovery at 500,1000,and 2000 Hz compared to the control group (P<0.001).Vertigo resolution (72.22% vs.35.29%) and tinnitus improvement (70.37% vs.40.86%) were significantly higher in the observation group (P<0.05),while aural fullness improvement showed no intergroup difference (P>0.05).The total effective rate was 80.00% in the observation group versus 57.10% in the control group (P<0.05).Conclusion:The combination of Jin’s Three-Needle therapy and ITDI synergistically enhances hearing recovery and symptom relief in total deafness-type SSNHL,potentially through improved inner ear microcirculation,targeted drug delivery,and neuroprotection.This integrated traditional Chinese and Western medicine approach offers a novel strategy for refractory SSNHL,though its precise mechanisms require further validation.

参考文献/References:

[1]SK P.Intratympanic corticosteroids for sudden sensorineural hearing loss[J].The Cochrane Database of Systematic Reviews,2022,7(7):CD008080.
[2]HU Y,YE Y,JI X,et al.The role of hyperbaric oxygen in idiopathic sudden sensorineural hearing loss[J].Medical Gas Research,2024,14(4):180-185.
[3]HOCH S,KREMPER L,RUDHART S A,et al.Role of intratympanic glucocorticoid treatment in sudden hearing loss[J].Hno,2024,72(4):291-302.
[4]LIN C Y,CHANG C H,CHANG C J,et al.Salvage therapy for refractory sudden sensorineural hearing loss (RSSNHL):A systematic review and network meta-analysis[J].International Journal of Audiology,2025,64(1):1-10.
[5]WANG Y,ZHAO J,WU J,et al.Comparison of side effects of different steroids used in intratympanic injections[J].American Journal of Otolaryngology,2024,45(3):104258.
[6]WANG H,ZHAO Z,CHEN S.Local vs systemic use of steroids for sudden deafness with diabetes:A systematic review and meta-analysis[J].Ear,Nose & Throat Journal,2023:014556132311700.
[7]JUNG J W,LI H,LEE J H,et al.Dual viscosity mixture vehicle for intratympanic steroid treatment modifies the ROS and inflammation related proteomes[J].Frontiers in Pharmacology,2023,14:1081724.
[8]DING Y,HOU Z,WANG M,et al.Mastoid approach for local drug delivery to the inner ear for treating hearing loss[J].Journal of Controlled Release:Official Journal of the Controlled Release Society,2024,376:488-501.
[9]LI L Q,BENNETT A M D.Probability of clinically significant hearing recovery following salvage intratympanic steroids for sudden sensorineural hearing loss in the “real world”[J].Journal of Laryngology and Otology,2022,136(9):831-838.
[10]LIANG S,LI Y,GUO Z,et al.Modified intratympanic steroid therapy for sudden sensorineural hearing loss via tympanic tube and gelfoam as a salvage treatment[J].Journal of Otology,2024,19(1):19-23.
[11]WANG S Y,FU W T,YU M,et al.Efficacy analysis of intratympanic injection of dexamethasone at different concentrations for the treatment of unilateral idiopathic sudden sensorineural hearing loss[J].American Journal of Otolaryngology,2025,46(2):104603.
[12]JIA Q,ZHU J,WU D,et al.Comparison of batroxobin versus the combination of batroxobin and intratympanic dexamethasone injection in the treatment of sudden sensorineural hearing loss[J].Ear,Nose,and Throat Journal,2024:1455613231222381.
[13]刘国强,郭琳娟,贺阿利,等.放血联合电针治疗突发性耳聋临床研究[J].陕西中医,2024,45(7):980-984.
[14]陶盟,张涛.突发性耳聋针灸治疗近况[J].社区医学杂志,2020,18(6):465-468.
[15]REN W,TAO B,DENG H.The efficacy and safety of acupuncture in the treatment of sudden sensorineural hearing loss:A systematic review and meta-analysis[J].Integrative Medicine Research,2024,13(4):101087.
[16]SUN H,CHU C,WANG X,et al.The psychological intervention and clinical efficacy of rosenthal effect and acupuncture bleeding on middle-aged and young patients with sudden hearing loss[J].Medicine,2024,103(6):e36820.
[17]DONG C,YANG D,ZHANG P,et al.Sudden sensorineural hearing loss is related to endothelial progenitor cells and lipoprotein-associated phospholipase A2[J].The Journal of International Advanced Otology,2023,19(2):76-80.
[18]DENG H S,HOU Y W,ZHANG J N,et al.Postauricular versus systemic use of steroids for sudden hearing loss:A systematic review and meta-analysis of randomized controlled trials[J].Medicine,2023,102(32):e34494.
[19]ZOU J.Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy[J].Journal of Otology,2024,19(1):55-58.
[20]NELSON L,SWANSON D,BOROWIEC E,et al.The impact of intratympanic steroid dosage on hearing recovery in sudden sensorineural hearing loss[J].Annals of Otology,Rhinology and Laryngology,2023,132(8):879-887.
[21]ASKAR A A,GHONIM M R,SHABANA Y K.Discriminant analysis of the prognostic factors for hearing outcomes in patients with idiopathic sudden sensorineural hearing loss[J].The Journal of International Advanced Otology,2023,19(3):162-168.
[22]李蕙萍,曾智君,袁青.袁青从“脑-元神”论治难治性突发性耳聋经验[J].中医药导报,2022,28(1):165-167,171.
[23]LI J,ZHU X,YE S,et al.Tanshinone ⅡA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway[J].Acta Biochimica et Biophysica Sinica,2024,57(4):1-11.
[24]SINA R E,LIPPERT J,GUARDARDO K.Osteopathic cranial manipulative medicine as a proposed addition to the treatment regimen for idiopathic sudden-onset unilateral sensorineural hearing loss:A case report[J].Cureus,2023,15(11):e49728.
[25]FENG S J,LEONG S,AKSIT A,et al.Physiologic effects of microneedle-mediated intracochlear dexamethasone injection in the guinea pig[J].Laryngoscope,2024,134(1):388-392.
[26]LAN W C,LIN C D,TSOU Y A,et al.Primary versus salvage intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss[J].Laryngoscope Investigative Otolaryngology,2023,8(4):1029-1035.
[27]SUN X,CHEN L,HU N,et al.Clinical value of auditory nerve enhancement in idiopathic sudden sensorineural hearing loss:A retrospective study[J].Frontiers in Neurology,2024,15:1410516.
[28]OKUDA H,AOKI M,OHASHI T,et al.Serum fibrinogen level and cytokine production as prognostic biomarkers for idiopathic sudden sensorineural hearing loss[J].Otology & Neurotology:Official Publication of the American Otological Society,American Neurotology Society and European Academy of Otology and Neurotology,2022,43(7):e712-e719.

备注/Memo

备注/Memo:
国家自然科学基金资助项目(81760882)
更新日期/Last Update: 2025-09-08