[1]刘佳宁,任佳杰,胡蝶,等.基于PI3 K/AKT信号通路探究中医药防治复发性流产研究进展[J].陕西中医,2025,46(9):1289-1293.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.028]
　LIU Jianing,REN Jiajie,HU Die,et al.Explore the prevention and treatment of traditional Chinese medicine based on PI3K/AKT signaling pathway Research progress of recurrent abortion[J].,2025,46(9):1289-1293.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.028]
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基于PI3 K/AKT信号通路探究中医药防治复发性流产研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年9期
页码:
1289-1293
栏目:
综 述
出版日期:
2025-09-05

文章信息/Info

Title:
Explore the prevention and treatment of traditional Chinese medicine based on PI3K/AKT signaling pathway Research progress of recurrent abortion
作者:
刘佳宁1; 任佳杰1; 胡蝶1; 冯晓玲2
（1.黑龙江中医药大学研究生院，黑龙江 哈尔滨 150040；2.黑龙江中医药大学附属第一医院妇科二科，黑龙江 哈尔滨 150040）
Author(s):
LIU Jianing1; REN Jiajie1; HU Die1; FENG Xiaoling2
（1.Graduate School，Heilongjiang University of Chinese Medicine，Harbin 150040，China；2.Department Two of Gynecology，First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China）
关键词:
复发性流产; PI3K/AKT信号通路; 中药复方; 中药有效成分; 临床疗效; 研究思路
Keywords:
Recurrent spontaneous abortion; PI3K/AKT signaling pathway; Chinese medicine compound; Effective components of Chinese medicine; Clinical efficacy; Research ideas
分类号:
R 714.21
DOI:
DOI:10.3969/j.issn.1000-7369.2025.09.028
文献标志码:
A
摘要:
复发性流产（RSA）是指与同一配偶连续自然流产两次或两次以上，是一种临床常见妊娠合并症，对妇女身心健康构成严重威胁的。研究表明，磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/AKT）信号通路在RSA的病理特性调控中扮演着重要角色，这一信号通路广泛参与细胞增殖、凋亡、侵袭、上皮间充质转化（EMT）以及血管生成等过程。在RSA的精确预防和治疗上，中医药展现出了巨大的优越性。研究发现，通过对PI3K/AKT信号途径的调整，中药的有效成分和复方能够降低孕期流产的风险。本文通过阐述 PI3K/AKT信号通路关键靶点与RSA的联系，归纳总结国内外近年来使用中药调控PI3K/AKT信号通路治疗RSA的研究现状，为中药治疗RSA提供新的思路。
Abstract:
Recurrent spontaneous abortion (RSA) refers to two or more consecutive spontaneous abortions with the same spouse,which is a common clinical complication of pregnancy and poses a serious threat to women’s physical and mental health.Studies have shown that the phosphatidylinositol-3 kinase/protein kinase B (PI3K/AKT) signaling pathway plays an important role in the regulation of the pathological characteristics of recurrent abortion (RSA),and is widely involved in cell proliferation,apoptosis,invasion,epithelial mesenchymal transformation (EMT),and angiogenesis.In the precise prevention and treatment of RSA,traditional Chinese medicine has shown great superiority.The study found that by adjusting the PI3K/AKT signaling pathway,the ingredients and compounds of Chinese medicine can reduce the risk of pregnancy abortion.By elaborating the relationship between key targets of PI3K/AKT signaling pathway and RSA,this paper summarized the current research status of regulating PI3K/AKT signaling pathway with traditional Chinese medicine in the treatment of RSA in recent years at home and abroad,providing new ideas for the treatment of RSA with traditional Chinese medicine.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(8217150728)；黑龙江省自然科学基金资助项目(ZD2021H006)
更新日期/Last Update: 2025-09-08