[1]郭可宁,张婷婷,王玲玲,等.肾虚肝郁型卵巢储备功能减退患者心率变异性研究[J].陕西中医,2025,46(12):1622-1627.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.007]
　GUO Kening,ZHANG Tingting,WANG Lingling,et al.A study of heart rate variability in patients with diminished ovarian reserve of the kidney deficiency and liver depression syndrome type[J].,2025,46(12):1622-1627.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.007]
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肾虚肝郁型卵巢储备功能减退患者心率变异性研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年12期
页码:
1622-1627
栏目:
临床研究
出版日期:
2025-12-05

文章信息/Info

Title:
A study of heart rate variability in patients with diminished ovarian reserve of the kidney deficiency and liver depression syndrome type
作者:
郭可宁1; 张婷婷1; 王玲玲2; 唐红3; MUNSOON HONG1(韩国); 谭丽1
（1.上海中医药大学附属岳阳中西医结合医院，上海 200437；2.上海市北蔡社区卫生服务中心，上海 201204；3.桐乡市皮肤病防治院，浙江 嘉兴 314500）
Author(s):
GUO Kening1; ZHANG Tingting1; WANG Lingling2; TANG Hong3; MUNSOON HONG1; TAN Li1
（1.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200437,China; 2.Community Health Service Center in Beicai Town,Pudong New District,Shanghai 201204，China; 3.Tongxiang Skin Disease Prevention and Control Hospital,Jiaxing 314500,China）
关键词:
卵巢储备功能减退; 心率变异性; 肾虚肝郁; 自主神经功能紊乱; 育肾调肝法; 临床特点; 诊断价值
Keywords:
Diminished ovarian reserve; Heart rate variability; Kidney deficiency and liver depression syndrome type; Cardiovascular autonomic dysfunction; Modified kidney-nourishing and liver-regulating prescriptions; Clinical features; Diagnostic value
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.12.007
文献标志码:
A
摘要:
目的：探讨肾虚肝郁型卵巢储备功能减退（DOR）患者的心率变异性。方法：分别收集55 例肾虚肝郁型卵巢储备功能低下（DOR）的育龄期女性及34 例卵巢储备功能正常的育龄期女性的心率变异性（HRV）数据；给予55例肾虚肝郁型DOR患者3个月经周期的蔡氏育肾调肝法治疗，比较治疗前后HRV数据、中医证候积分及应用焦虑自评量表（SAS评分）、应用抑郁自评量表（SDS评分）。结果：肾虚肝郁型DOR患者的心率变异性参数呈现特征性改变，即R-R间期标准差（SDNN）、相邻R-R间期差异均方根值（RMSSD）及相邻R-R间期差异超过50 ms的比例（PNN50）等时域指标显著降低（P<0.05）；频域分析中的低频功率（LF）与高频功率（HF）的绝对值均低于正常育龄对照组，低频功率与高频功率的比值（LF/HF）呈现显著高于对照组（P<0.05）。经蔡氏育肾调肝法治疗后患者SDNN、RMSSD、PNN50、HF均高于治疗前（P<0.05），LF/HF低于治疗前（P<0.05），治疗后患者中医证候积分、SAS评分、SDS评分均有下降（P<0.05）。结论：肾虚肝郁型DOR患者存在自主神经功能改变，即交感神经活动增加、迷走神经活动减弱，且交感迷走神经平衡逐渐向交感神经过度活动转变，且经蔡氏育肾调肝法可促进自主神经功能恢复平衡，为患者临床症状严重程度提供量化的客观依据，支持临床决策，对优化诊疗路径、实现个体化治疗具有指导意义。
Abstract:
Objective:To observe heart rate variability (HRV) in patients with diminished ovarian reserve (DOR).Methods:Heart rate variability data were collected from 55 women of childbearing age with DOR of the kidney deficiency and liver depression syndrome type and 34 age-matched women with normal ovarian reserve.The DOR group received modified kidney-nourishing and liver-regulating prescriptions for three menstrual cycles.Results:Compared to the normal group,DOR patients exhibited significantly lower SDNN,RMSSD,PNN50,LF,and HF values (P<0.05),while their LF/HF ratio was significantly higher(P<0.05).Following treatment with t modified kidney-nourishing and liver-regulating prescriptions,patients exhibited significantly higher SDNN,RMSSD,PNN50,and HF values compared to pre-treatment levels(P<0.05),while LF/HF ratios were significantly lower than pre-treatment levels (P<0.05).Post-treatment,patients demonstrated significant reductions in Traditional Chinese Medicine syndrome scores,SAS scores,and SDS scores (P<0.05).Conclusion:Patients with DOR characterized by kidney deficiency and liver stagnation exhibit autonomic nervous system dysfunction,specifically increased sympathetic activity and diminished vagal activity.This imbalance progressively shifts toward sympathetic hyperactivity.Cai’s method for nourishing the kidneys and regulating the liver promotes the restoration of autonomic balance.This provides quantifiable,objective evidence regarding the severity of clinical symptoms,supports clinical decision-making,and offers guidance for optimizing treatment pathways and achieving personalized therapy.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374499）；张婷婷教授上海市名老中医学术经验研究工作室（SHGZS-20222）；上海中医药大学科技发展基金资助项目（23KFL116）；国家中医药管理局高水平中医药重点学科建设项目（ZYYZDKK-2023065）
更新日期/Last Update: 2025-12-08