[1]邵淑娟,陈苏宁,郝蕊,等.榆栀止血颗粒治疗异常子宫出血的有效性及安全性研究[J].陕西中医,2025,46(12):1637-1641.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.010]
　SHAO Shujuan,CHEN Suning,HAO Rui,et al.Study on the efficacy and safety of Yuzhi Zhixue granules in the treatment of abnormal uterine bleeding[J].,2025,46(12):1637-1641.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.010]
点击复制

榆栀止血颗粒治疗异常子宫出血的有效性及安全性研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年12期
页码:
1637-1641
栏目:
临床研究
出版日期:
2025-12-05

文章信息/Info

Title:
Study on the efficacy and safety of Yuzhi Zhixue granules in the treatment of abnormal uterine bleeding
作者:
邵淑娟1; 陈苏宁1; 郝蕊2; 武丽蕊1; 李丹3
（1.河北中石油中心医院妇科，河北 廊坊 065000；2.河北中石油中心医院产科，河北 廊坊065000；3.河北中石油中心医院中医科，河北 廊坊 065003）
Author(s):
SHAO Shujuan1; CHEN Suning1; HAO Rui2; WU Lirui1; LI Dan3
(1.Department of Gynecology,CNPC Central Hospital of Hebei,Langfang 065000,China;2.Department of Obstetrics,CNPC Central Hospital of Hebei,Langfang 065000,China;3.Department of Traditional Chinese Medicine,CNPC Central Hospital of Hebei,Langfang 065003,China)
关键词:
异常子宫出血; 榆栀止血颗粒; 凝血功能; 子宫内膜厚度; 有效性; 安全性
Keywords:
Abnormal uterine bleeding; Yuzhi Zhixue granules; Coagulation function; Endometrial thickness; Effectiveness; Security
分类号:
R 711.52
DOI:
DOI:10.3969/j.issn.1000-7369.2025.12.010
文献标志码:
A
摘要:
目的：研究榆栀止血颗粒治疗异常子宫出血（AUB）的有效性及安全性。方法：回顾性选取200例AUB患者为研究对象，依据不同治疗方式分为两组：对照组（91例）实施常规治疗，观察组（109例）实施常规治疗联合榆栀止血颗粒药物治疗并对纳入患者行为期2个月的随访。收集两组患者一般资料，对比两组疗效、临床指标（止血与凝血效果、贫血情况）、肝肾及凝血功能，并统计治疗期间不良事件发生率。结果：治疗后两组中医证候积分均降低，且观察组明显低于对照组，差异有统计学意义（P＜0.05）；治疗后观察组总有效率优于对照组（91.74% 与79.12%），差异具有统计学意义（P＜0.05）。治疗后2个月对照组与观察组的血清铁蛋白均较治疗前有显著提升，完全止血时间、经期持续时间、子宫内膜厚度及月经失血图评分值（PBAC）较治疗前明显降低，各项指标差异均有统计学意义（P<0.05）。治疗后2个月对照组与观察组丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）水平均较治疗前显著升高，差异具有统计学意义（P＜0.001）；肌酐（Cr）水平在组间组内均无统计学差异（P＞0.05）；凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）均较治疗前显著降低且组间比较差异也具有统计学意义（P＜0.001）。观察组较对照组在治疗期间不良事件总发生率（13.76% 与8.80%）比较差异无统计学意义（P＞0.05）。结论：榆栀止血颗粒治疗AUC患者显著提升临床治疗有效率，其作用机制或与有效缩短经期持续时间、降低经量及改善凝血功能指标相关，对肝肾功能影响轻微且具有较高用药安全性。
Abstract:
Objective:To investigate the efficacy and safety of Yuzhi Zhixue granules in treating abnormal uterine bleeding (AUB).Methods:A total of 200 AUB patients were retrospectively selected as the study objects,and were divided into two groups according to different treatment Methods:control group (91 cases) received conventional treatment,study group (109 cases) received conventional treatment combined with Yuzhi Zhixue granules,and the behavioral period of included patients was followed up for 2 months.Baseline data of the two groups were collected,and the efficacy,clinical indicators (hemostasis and coagulation effect,anemia),liver,kidney and coagulation function of the two groups were compared,and the incidence of adverse events during treatment was statistically significant.Results:After the treatment,the TCM syndrome scores of both groups decreased,and the scores of the observation group were significantly lower than those of the control group,with statistically significant differences (P<0.05).After treatment,the total effective rate of the study group was better than that of the control group (91.74% vs 79.12%),and the difference was statistically significant (P＜0.010).After 2 months of treatment,the serum ferritin level in both control group and study group was significantly improved compared with that before treatment,and the complete hemostasis time,menstrual duration,endometrial thickness and PBAC were significantly decreased compared with that before treatment,and the differences in all indexes showed statistical significance (P<0.05).ALT and AST levels in control group and study group were significantly higher than before treatment 2 months after treatment,and the difference was statistically significant (P<0.001).There were no significant differences in Cr levels between groups (P>0.05).The levels of PT and APTT were significantly lower than those before treatment,and the difference between groups was statistically significant (P<0.001).There was no significant difference in the total incidence of adverse events between the study group and the control group (13.76% vs 8.80%) during treatment (P>0.05).Conclusion:Yuzhi Zhixue granules can significantly improve the clinical treatment efficiency of AUC patients,and its mechanism of action may be related to effectively shortening menstrual duration,reducing menstrual volume and improving coagulation function indicators.This drug has a slight effect on liver and kidney function at the therapeutic dose and has a high drug safety.

参考文献/References:

[1]LEBDUSKA E,BESHEAR D,SPATARO B M.Abnormal uterine bleeding[J].Med Clin North Am,2023,107(2):235-246.
[2]JAIN V,MUNRO M G,CRITCHLEY H O D.Contemporary evaluation of women and girls with abnormal uterine bleeding:FIGO systems 1 and 2[J].Int J Gynaecol Obstet,2023,162 (Suppl 2):29-42.
[3]石丽萍,郭子玲,韩俊.补肾养血调经汤加减治疗异常子宫出血肝肾阴虚证疗效研究[J].陕西中医,2021,42(9):1197-1200.
[4]SCHRAGER S,FOX K,LEE R.Abnormal uterine bleeding associated with hormonal contraception[J].Am Fam Physician,2024,109(2):161-166.
[5]尹艳艳,明亮,李前进,等.妇科止血颗粒对早孕大鼠子宫出血的影响[J].安徽医科大学学报,2003,38(2):120-122.
[6]中华医学会妇产科学分会妇科内分泌学组.异常子宫出血诊断与治疗指南（2022更新版）[J].中华妇产科杂志，2022，57(7):481-490.
[7]杜惠兰,孙莹.国际中医临床实践指南崩漏(2019-10-11)[J].世界中医药,2021,16（6）：870-877.
[8]崔娜,张陈萍,雷磊.炔雌醇环丙孕酮片治疗围绝经期异常子宫出血的临床效果及对患者子宫内膜厚度和性激素水平的影响[J].临床医学研究与实践,2022,7(12):100-103.
[9]BRUN J L,PLU-BUREAU G,HUCHON C,et al.Management of women with abnormal uterine bleeding:Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF)[J].Eur J Obstet Gynecol Reprod Biol,2023,288:90-107.
[10]国家食品药品监督局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:143-151.
[11]PAPAKONSTANTINOU E,ADONAKIS G.Management of pre-,peri-,and post-menopausal abnormal uterine bleeding:When to perform endometrial sampling? [J].Int J Gynaecol Obstet,2022,158(2):252-259.
[12]ZHANG Y Y,HUANG R,LIU X C,et al.Taohong siwu decoction ameliorates abnormal uterine bleeding via inhibiting ACSL4-mediated ferroptosis[J].J Ethnopharmacol,2025,339:119130.
[13]陈绵,陈燕娥,吴颖.固崩止漏汤联合妈富隆治疗围绝经期异常子宫出血临床研究[J].陕西中医,2020,41(4):453-455.
[14]HU X L,WU H M,YONG X,et al.Cyclical endometrial repair and regeneration:Molecular mechanisms,diseases,and therapeutic interventions[J].Med Comm,2023,4(6):e425.
[15]党苗苗,李转平,李萌萌.实时阴道超声检查在人工流产术中的应用效果及对患者术后子宫内膜修复周期监测价值研究[J].陕西医学杂志,2021,50(7):814-817.
[16]朱爱民,徐晓宏,陈秋香,等.罗沙司他对维持性腹膜透析患者贫血指标及心功能的影响[J].世界临床药物.2024,45(2):147-152.
[17]王敏,裴巧丽,朱丽红,等.缺铁性贫血孕妇血清可溶性转铁蛋白受体、膜铁转运蛋白1、对氧磷酶1表达水平及检测意义[J].陕西医学杂志,2024,53(8):1106-1109.
[18]ZHANG C H,WEI F J,WANG X W,et al.Mechanism of Yuzhi Zhixue granules in treating polycystic ovary syndrome in rats[J].Zhongguo Zhong Yao Za Zhi,2024,49(20):5516-5527.
[19]苏先芝,陆华,黎欣韵,等.榆栀止血颗粒通过HIF-1α/VEGF通路缓解肾阴虚型异常子宫出血[J].中药药理与临床,2025,41(6):24-29.
[20]SAINI R,SHARMA N,OLADEJI O S,et al.Traditional uses,bioactive composition,pharmacology,and toxicology of Phyllanthus emblica fruits:A comprehensive review[J].J Ethnopharmacol,2022,282:114570.
[21]JIN T,CHI L,MA C.Agrimonia pilosa:A phytochemical and pharmacological review[J].Evid Based Complement Alternat Med,2022,2022:3742208.
[22]CHEN S,WANG X,CHENG Y,et al.A review of classification,biosynthesis,biological activities and potential applications of flavonoids[J].Molecules,2023,28(13):4982.
[23]YIN Q N,ZHANG X Q,LIAO S Q,et al.Potential anticoagulant of traditional chinese medicine and novel targets for anticoagulant drugs[J].Phytomedicine,2023,116:154880.
[24]XUAN Y Y,WU D T,ZHANG Q,et al.Elevated ALT/AST ratio as a marker for NAFLD risk and severity:Insights from a cross-sectional analysis in the United States[J].Front Endocrinol (Lausanne),2024,15:1457598.
[25]BALANDINA A N,KOLTSOVA E M,SHIBEKO A M,et al.Platelets provide robustness of spatial blood coagulation to the variation of initial conditions[J].Thromb Res,2023,230:133-143.

相似文献/References:

[1]石丽萍,郭子玲,韩 俊.补肾养血调经汤加减治疗异常子宫出血肝肾阴虚证疗效研究[J].陕西中医,2021,(9):1197.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.011]

备注/Memo

备注/Memo:
河北省卫生健康委员会计划项目（202302037）；河北省廊坊市科技局项目（2023013038）
更新日期/Last Update: 2025-12-08