[1]闫芳芳,李淑荣,赵倩倩,等.基于“气血理论”探讨细胞自噬与复发性流产的关系[J].陕西中医,2025,46(12):1663-1668.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.016]
　YAN Fangfang,LI Shurong,ZHAO Qianqian,et al.To investigate the relationship between autophagy and recurrent spontaneous abortion based on the theory of Qi and blood[J].,2025,46(12):1663-1668.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.016]
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基于“气血理论”探讨细胞自噬与复发性流产的关系

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年12期
页码:
1663-1668
栏目:
学术探讨
出版日期:
2025-12-05

文章信息/Info

Title:
To investigate the relationship between autophagy and recurrent spontaneous abortion based on the theory of Qi and blood
作者:
闫芳芳1; 李淑荣2; 赵倩倩1; 王丽娜2; 徐广立3; 陈萍2
（1.河南中医药大学第一临床医学院，河南 郑州 450046；2.河南中医药大学第一附属医院妇产科，河南 郑州 450046；3.河南中医药大学第一附属医院生殖科，河南 郑州 450046）
Author(s):
YAN Fangfang1; LI Shurong2; ZHAO Qianqian1; WANG Lina2; XU Guangli3; CHEN Ping2
（1.The First Clinical Medical College of Henan University of Traditional Chinese Medicine，Zhengzhou 450046，China;2.Department of Obstetrics and Gynaecology,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine，Zhengzhou 450046，China;3.Department of Reproductive Medicine,First Affiliated Hospital of Henan University of Traditional Chinese Medicine，Zhengzhou 450046，China）
关键词:
复发性流产; 气血理论; 细胞自噬; 补益气血; 调畅气血; 孕前调治
Keywords:
Recurrent spontaneous abortion; Qi and blood theory; Autophagy; Tonifying Qi and blood; Regulating and smoothing Qi and blood; Pre - pregnancy conditioning and treatment
分类号:
R 714.21
DOI:
DOI:10.3969/j.issn.1000-7369.2025.12.016
文献标志码:
A
摘要:
复发性流产（RSA)的发病率逐年上升，现研究发现细胞自噬是复发性流产发生发展过程中重要的病理机制之一。中医认为，复发性流产是本虚标实之症，气血失调为本病发病之本，以气血乏源，脾肾亏虚为本，气血不畅，瘀血阻滞为标。在微观层面上，细胞自噬与气血关系密切，细胞自噬与气的功能高度同构，是气的微观功能体现，而气的生成离不开血的濡养，故血的濡养是细胞自噬的基础。气血失调均会导致自噬的过度激活或减少，进而通过影响内膜蜕膜化和滋养细胞侵袭等关键环节参与RSA的发生。因此补益气血、调畅气血是中医药调控细胞自噬、恢复母胎界面稳态的核心治则。本文旨在构建“气血-自噬-RSA”的理论联系，为临床应用中医药通过调控自噬治疗RSA提供新思路。
Abstract:
The incidence of recurrent spontaneous abortion (RSA) has been increasing year by year.Current research has found that autophagy is one of the important pathological mechanisms in the occurrence and development of RSA.Traditional Chinese medicine (TCM) holds that RSA is a disease characterized by deficiency in the root and excess in the branch.The imbalance of qi and blood is the fundamental cause of this disease,with insufficient sources of qi and blood and deficiency of the spleen and kidney being the root causes,and poor circulation of qi and blood and stasis of blood being the branch manifestations.At the microscopic level,autophagy is closely related to qi and blood.Autophagy is highly isomorphic with the functions of qi and is a microscopic manifestation of the functions of qi.Moreover,the generation of qi cannot be separated from the nourishment of blood,so the nourishment of blood is the basis for autophagy.Imbalances in qi and blood can lead to either excessive activation or reduction of autophagy,which in turn participates in the occurrence of RSA by affecting key processes such as endometrial decidualization and trophoblast invasion.Therefore,tonifying and regulating qi and blood are the core treatment principles of TCM for regulating autophagy and restoring the homeostasis of the maternal-fetal interface.This paper aims to establish a theoretical connection among “qi and blood-autophagy-RSA”,providing new ideas for the clinical application of TCM in treating RSA by regulating autophagy.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目(82074167)；河南省重点研发专项项目（241111310900）；河南省中医药科研专项课题（2023ZY2031）；河南省高等学校重点专科项目（23A360020）；王丽娜名老中医工作室（CZ0250-05）
更新日期/Last Update: 2025-12-08