[1]王世宇,李瑞萍,吴尓媚,等.基于内质网应激与自噬探讨炎症性肠病发病机制与中医药研究进展[J].陕西中医,2026,(1):137-140,144.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.025]
　WANG Shiyu,LI Ruiping,WU Ermei,et al.Exploring the pathogenesis of inflammatory bowel disease based on endoplasmic reticulum stress and autophagy and the progress of traditional Chinese medicine intervention research[J].,2026,(1):137-140,144.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.025]
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基于内质网应激与自噬探讨炎症性肠病发病机制与中医药研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年1期
页码:
137-140,144
栏目:
综 述
出版日期:
2026-01-05

文章信息/Info

Title:
Exploring the pathogenesis of inflammatory bowel disease based on endoplasmic reticulum stress and autophagy and the progress of traditional Chinese medicine intervention research
作者:
王世宇1; 李瑞萍1; 吴尓媚1; 魏秀楠1; 王亚静1; 孙大娟2
（1.山东中医药大学，山东 济南 250014；2.山东中医药大学附属医院，山东 济南 250014）
Author(s):
WANG Shiyu1; LI Ruiping1; WU Ermei1; WEI Xiunan1; WANG Yajing1; SUN Dajuan2
（1.Shandong University of Chinese Medicine，Ji’nan 250014，China；2.Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Ji’nan 250014，China）
关键词:
炎症性肠病; 内质网应激; 自噬; 中医药; 研究进展
Keywords:
Inflammatory bowel disease; Endoplasmic reticulum stress; Autophagy; Chinese medicine; Research progress
分类号:
R 574
DOI:
DOI:10.3969/j.issn.1000-7369.2026.01.025
文献标志码:
A
摘要:
炎症性肠病(IBD)是一种慢性非特异性疾病，且发病率逐年上升，其发病机制尚未完全明确。目前研究结果表明，IBD的进展与内质网应激（ERS）、自噬密不可分。持续的ERS可引起炎症反应、损伤肠黏膜屏障功能促引起进IBD的发生，而自噬可以清除错误折叠蛋白的积累从而维持内质网稳态。中医药具有多靶点、多通路、副作用小等特点，在防治IBD中具有显著临床疗效。本研究以ERS与自噬为切入点，从炎症反应、肠黏膜屏障、免疫反应几方面探讨了其对IBD发生发展的影响，并总结目前中药单体、复方及中医特色疗法通过调控ERS及自噬治疗IBD的研究进展，为深入了解IBD的发病机制提供理论支持，为中医药治疗IBD提供新思路。
Abstract:
Inflammatory bowel disease (IBD) is a chronic non-specific disease and its incidence is increasing year by year,and its pathogenesis has not been fully clarified.The current findings suggest that the progression of IBD is inextricably linked to endoplasmic reticulum stress (ERS) and autophagy.Sustained ERS can cause inflammatory response and damage the barrier function of intestinal mucosa to promote the development of IBD,while autophagy can remove the accumulation of misfolded proteins to maintain endoplasmic reticulum homeostasis.With the characteristics of multi-targets,multi-pathways and low side-effects,TCM has significant clinical efficacy in the prevention and treatment of IBD.In this study,we took ERS and autophagy as the entry point,explored their effects on the development of IBD from the aspects of inflammatory response,intestinal mucosal barrier and immune response,and summarised the current progress of the research on the regulation of ERS and autophagy by traditional Chinese medicine (TCM) single-pharmaceuticals,compound formulas and TCM speciality therapies in the treatment of IBD,so as to provide theoretical support for the in-depth understanding of the pathogenesis of IBD,and to provide a new way of thinking for the treatment of IBD with TCM.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82205057）；山东省博士后创新项目（SDCX-2G-202502108）
更新日期/Last Update: 2026-01-08