[1]郑秀莲,林建平,雷良枭,等.基于“诸痿发于肺热”理论探讨 TGF-β1/Smad信号通路在间质性肺病并发骨质疏松症中的作用机制[J].陕西中医,2026,(3):360-365.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.013]
　ZHENG Xiulian,LIN Jianping,LEI Liangxiao,et al.Exploring the role of TGF-β1/Smad signaling pathway in interstitial lung disease with osteoporosis based on the theory of “all impotence originates from lung heat”[J].,2026,(3):360-365.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.013]
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基于“诸痿发于肺热”理论探讨 TGF-β1/Smad信号通路在间质性肺病并发骨质疏松症中的作用机制

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
360-365
栏目:
学术探讨
出版日期:
2026-03-05

文章信息/Info

Title:
Exploring the role of TGF-β1/Smad signaling pathway in interstitial lung disease with osteoporosis based on the theory of “all impotence originates from lung heat”
作者:
郑秀莲1; 林建平2; 雷良枭1; 汪冬梅1; 孙漪凡1; 陈少清1
（1.福建中医药大学康复医学院，福建 福州 350122；2.福建医科大学健康学院，福建 福州 350122）
Author(s):
ZHENG Xiulian1; LIN Jianping2; LEI Liangxiao1; WANG Dongmei1; SUN Yifan1; CHEN Shaoqing1
(1.College of Rehabilitation Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China；2.The School of Health,Fujian Medical University,Fuzhou 350122,China）
关键词:
间质性肺病; 骨质疏松症; 诸痿发于肺热; 肺热叶焦; TGF-β1/Smad信号通路; 作用机制
Keywords:
Interstitial lung disease; Osteoporosis; All impotence originates from lung heat; The scorched lung; TGF-β1/Smad signaling pathway; Mechanism of action
分类号:
R 563.9
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.013
文献标志码:
A
摘要:
间质性肺病（ILD）是一类以弥漫性肺泡炎以及肺间质纤维化为主要病理表现的疾病总称。骨质疏松症（OP）是ILD常见的并发症之一，表现为骨质量和骨强度降低。中医方面，ILD、OP分别属于“肺痿”“骨痿”范畴。ILD合并OP，二者相互影响及共存给临床诊治带来极大挑战，严重影响患者生存质量。TGF-β1/Smad信号传导通路在间质纤维化和骨代谢中呈现正负反馈调节。异常的TGF-β1/Smad信号传导与肺热密切相关，扰乱机体内环境稳态，在ILD合并OP的发生发展中扮演重要角色。本文基于中医学“诸痿发于肺热”理论，探讨间质性肺病并发骨质疏松症时TGF-β1/Smad信号传导通路的作用机制，以期为临床诊治提供新的理论依据和靶向治疗思路。
Abstract:
Interstitial lung disease (ILD) is a group of diseases with diffuse alveolitis and interstitial fibrosis as the main pathological manifestations.Osteoporosis (OP) is one of the common complications of ILD,which is manifested by decreased bone mass and bone strength.In Chinese medicine,ILD and OP belong to the categories of “lung impotence” and “bone impotence”,respectively,and the interaction and coexistence of ILD and OP pose a great challenge to clinical diagnosis and treatment,which seriously affects the quality of patient’s survival.The TGF-β1/Smad signaling pathway shows positive and negative feedback regulation in interstitial fibrosis and bone metabolism.Abnormal TGF-β1/Smad signaling is closely related to lung fever,which disturbs the homeostasis of the internal environment and plays an important role in the development of ILD combined with OP.Based on the theory of “all impotence originates from lung heat” in Chinese medicine,this article discusses the mechanism of TGF-β1/Smad signaling pathway in ILD with osteoporosis,with the aim of providing a new theoretical basis for clinical diagnosis and treatment and ideas for targeted therapy.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目(81973924)；福建省财政资助专项（X2021003）
更新日期/Last Update: 2026-03-05