[1]邓倩瑜,姚菲,石玮,等.基于“炎癌转化”理论探讨 NETs与肺癌转移的关系[J].陕西中医,2026,(3):375-378.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.016]
　DENG Qianyu,YAO Fei,SHI Wei,et al.Exploring the relationship between NETs and lung cancer metastasis based on the “inflammation-cancer transformation” theory[J].,2026,(3):375-378.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.016]
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基于“炎癌转化”理论探讨 NETs与肺癌转移的关系

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
375-378
栏目:
学术探讨
出版日期:
2026-03-05

文章信息/Info

Title:
Exploring the relationship between NETs and lung cancer metastasis based on the “inflammation-cancer transformation” theory
作者:
邓倩瑜1; 姚菲2; 石玮2; 董福嫱1; 李宛津1; 李春姗2
（1.广西中医药大学，广西 南宁 530200；2.广西中医药大学第一附属医院，广西 南宁 530023）
Author(s):
DENG Qianyu1; YAO Fei2; SHI Wei2; DONG Fuqiang1; LI Wanjin1; LI Chunshan2
（1.Guangxi University of Traditional Chinese Medicine,Nanning 530200，China；2.The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530023，China）
关键词:
炎癌转化; 中性粒细胞胞外诱捕网; 肺癌转移; 炎症反应; 正虚毒结; 发生机制
Keywords:
Inflammatory and cancer transformation; Neutrophil extracellular trap; Lung cancer metastasis; inflammatory response; Deficiency of vital qi (Zheng Xu) and toxin accumulation; Pathogenesis
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.016
文献标志码:
A
摘要:
肺癌作为影响现代社会和个人健康的公共卫生问题，其发展及转化与炎症的存在息息相关。中医理论认为，“正虚毒结”是肺癌发生发展的病机关键。“毒”的不断累加最终促进了“炎-癌”转化，并与肺癌的转移密切相关。多项研究表明，中性粒细胞胞外诱捕网（NETs）与癌细胞存在相互影响，NETs增强炎性反应，加速炎-癌转化，据此我们提出“炎癌转化-NETs异常释放-肺癌转移”病因病机观点，为临床治疗提供新思路。
Abstract:
Lung cancer,as a public health issue affecting modern society and individual health,is closely associated with the presence of inflammation in its development and progression.According to traditional Chinese medicine theory,“deficiency of the body’s defensive energy and accumulation of toxins” is the key pathogenic mechanism underlying the occurrence and development of lung cancer.The continuous accumulation of toxins ultimately promotes the “inflammation-to-cancer” transformation and is closely related to lung cancer metastasis.Multiple studies have shown that neutrophil extracellular traps (NETs) interact with cancer cells,with NETs enhancing inflammatory responses and accelerating the inflammation-to-cancer transformation.Based on this,we propose the “inflammation-to-cancer transformation-abnormal NET release-lung cancer metastasis” etiological and pathomechanical perspective,offering new insights for clinical treatment.

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备注/Memo

备注/Memo:
国家自然科学基金资助地区项目（82260956）；广西自然科学基金资助面上项目（2025GXNSFAA069458）；广西中医药大学博士科研启动基金资助项目（2023BS037)
更新日期/Last Update: 2026-03-05