[1]何喃,林真静,许学兵.贺氏针灸三通法联合四逆汤对寒凝血瘀型原发性痛经患者性激素、疼痛介质及免疫功能的影响[J].陕西中医,2026,(3):406-410.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.023]
　HE Nan,LIN Zhenjing,XU Xuebing.Effects of HE’s Santong acupuncture methods combined with Sini decoction on sex hormones,pain mediators,and immune function in patients with primary dysmenorrhea of cold-congestion and blood stasis type[J].,2026,(3):406-410.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.023]
点击复制

贺氏针灸三通法联合四逆汤对寒凝血瘀型原发性痛经患者性激素、疼痛介质及免疫功能的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
406-410
栏目:
针灸经络
出版日期:
2026-03-05

文章信息/Info

Title:
Effects of HE’s Santong acupuncture methods combined with Sini decoction on sex hormones,pain mediators,and immune function in patients with primary dysmenorrhea of cold-congestion and blood stasis type
作者:
何喃; 林真静; 许学兵
（成都中医药大学附属医院龙泉医院 成都市龙泉驿区中医医院针灸科，四川 成都 610100）
Author(s):
HE Nan; LIN Zhenjing; XU Xuebing
（Department of Acupuncture,Chengdu Longquanyi District Traditional Chinese Medicine Hospital，Chengdu University of Traditional Chinese Medicine Affiliated Longquanyi Hospital,Chengdu 610100，China）
关键词:
原发性痛经; 性激素; 疼痛介质; 免疫功能; 四逆汤; 贺氏针灸三通法
Keywords:
Primary dysmenorrhea; Sex hormones; Pain mediators; Immune function; Sini decoction; HE’s Santong acupuncture methods
分类号:
R 271.113
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.023
文献标志码:
A
摘要:
目的：探讨贺氏针灸三通法联合四逆汤对寒凝血瘀型原发性痛经患者的治疗疗效，以及对性激素、疼痛介质和免疫功能的影响。方法：选取92例寒凝血瘀型原发性痛经患者，分为对照组和联合组，每组46例，对照组患者给予布洛芬止痛治疗，联合组患者在对照组治疗的基础上接受贺氏针灸三通法联合四逆汤治疗，比较治疗疗效，疼痛持续时间、中医证候积分、视觉模拟评分法（VAS）、前列腺素E2（PGE2）、血栓素B2（TBX2）、雌二醇（E2）、孕酮（P）以及外周血CD4+、CD8+和CD4+/CD8+T细胞比例。结果：联合组患者临床治疗总有效率显著高于对照组患者。治疗后，两组患者疼痛持续时间、中医证候积分、VAS评分以及血清PGE2、TBX2均较治疗前显著降低（P<0.05），并且联合组患者低于对照组患者（P<0.05）。对照组患者治疗后血清E2、P以及外周血CD4+、CD8+、CD4+/CD8+T细胞比例无较治疗前比较无统计学差异（P>0.05）；但联合组患者治疗后血清E2和外周血CD8+T细胞比较均显著下降（P<0.05），而血清P和外周血CD4+、CD4+/CD8+细胞比较均显著升高（P<0.05），且与对照组患者比较有统计学差异（P<0.05）。对照组和联合组治疗期间不良反应总发生率比较无统计学差异（4.35%与13.04%，P>0.05）。结论：贺氏针灸三通法联合四逆汤治疗原发性痛经患者有助于抑制疼痛介质的分泌，改善性激素分泌状态和提高免疫功能，进而缓解疼痛。
Abstract:
Objective:To study the therapeutic efficacy of HE’s Santong acupuncture methods combined with Sini Decoction in patients with primary dysmenorrhea due to cold coagulation and blood stasis and blood stasis,with respect to its modulatory effects on sexual hormones,pain-related mediators,and immune status.Methods:A total of 92 patients with cold and blood stasis type of primary dysmenorrhea were divided into a single treatment group and a joint group,with 46 patients in each group.The Single treatment group was given ibuprofen for pain relief,while the joint group received HE’s Santong acupuncture methods combined with Sini Decoction in addition to the treatment given to the Single treatment group.The therapeutic effects,duration of pain,TCM syndrome score,visual analog scale (VAS) score,prostaglandin E2 (PGE2),thromboxane B2 (TBX2),estradiol (E2),progesterone (P),and peripheral blood CD4+,CD8+,and CD4+/CD8+ T cell ratios were compared.Results:The overall effective rate of clinical treatment in patients in the joint group was higher than that of the Single treatment group.Post-treatment,the duration of pain,Traditional Chinese Medicine (TCM) syndrome scores,VAS scores,and serum PGE2 and TBX2 levels in both groups were significantly lower than before treatment (P<0.05),and the values in the joint group were lower than Single treatment group (P<0.05).In the Single treatment group,there were no differences in serum E2,P,or peripheral blood CD4+,CD8+,and CD4+/CD8+ T-cell ratios compared to before treatment (P>0.05).However,in the joint group,serum E2 and peripheral blood CD8 T-cells significantly decreased post-treatment (P<0.05),while serum P and peripheral blood CD4 and CD4/CD8 T-cell ratios significantly increased (P<0.05),with differences also observed compared to the Single treatment group (P<0.05).There was no difference in the overall incidence of adverse reactions between the control and joint groups during treatment (4.35% vs 13.04%,P>0.05).Conclusion:HE’s Santong acupuncture methods combined with Sini decoction helps to suppress the secretion of pain mediators,improve sex hormone secretion,and enhance immune function in patients with primary pain,thereby relieving pain.

参考文献/References:

[1]OSUGA Y,KOBAYASHI T,HIRAKAWA A,et al.Efficacy and safety of estetrol (15 mg)/drospirenone (3 mg) combination in a cyclic regimen for the treatment of primary and secondary dysmenorrhea:A multicenter,placebo-controlled,double-blind,randomized study[J].Fertil Steril,2025,123(4):700-708.
[2]NUHA K,RUSMIL K,GANIEM A R,et al.Single-blind randomized controlled trial:Comparative efficacy of dark chocolate,coconut water,and ibuprofen in managing primary dysmenorrhea[J].Int J Environ Res Public Health,2023,20(16):6619.
[3]龙金桃,郑文兰.原发性痛经的中西医发病机制及治疗研究进展[J].中国妇幼保健,2024,39(21):4359-4361.
[4]邵昱玮,陈嘉怡,张亚萍.基于CiteSpace中医药治疗原发性痛经的可视化分析[J].中国性科学,2023,32(9):139-144.
[5]洪秋阳,沈凌宇,刘晓静,等.贺氏三通法治疗气滞血瘀型脑卒中后失眠31例[J].中国针灸,2023,43(10):1207-1208.
[6]张艺馨,张欣雨,刘璐,等.贺氏三通针刺法联合静脉溶栓治疗急性缺血性脑卒中的临床疗效[J].中国中医基础医学杂志,2024,30(3):515-518.
[7]章恒端,向珺,舒运录,等.当归四逆汤对寒凝血瘀型子宫内膜异位症患者疼痛症状与生活质量的影响[J].中国医药导报,2022,19(31):143-145.
[8]冯琳琳,唐思琪,农运园,等.基于代谢组学和网络药理学的当归四逆汤改善寒凝血瘀致肾损伤作用机制研究[J].中国中药杂志,2023,48(24):6730-6739.
[9]《中医病证诊断疗效标准·原发性痛经》项目组,杜惠兰,梁潇,等.中医病证诊断疗效标准·原发性痛经(修订)[J].中华中医药杂志,2024,39(4):1884-1887.
[10]张勇,陈玲玲.温针灸联合四逆汤加味治疗寒凝血瘀型原发性痛经的疗效及对患者中医证候、血清PGE-2和PGF2a水平的影响[J].海南医学,2021,32(14):1817-1820.
[11]李丹丹,孙瞾,吴珠,等.加味温经汤联合温针灸对寒凝血瘀型原发性痛经患者疼痛介质及免疫功能的影响[J].世界中医药,2022,17(9):1326-1330.
[12]ITANI R,SOUBRA L,KAROUT S,et al.Primary dysmenorrhea:Pathophysiology,diagnosis,and treatment updates[J].Korean J Fam Med,2022,43(2):101-108.
[13]潘思安,刘余,汪少华,等.基于PI3K/Akt/mTOR信号通路探讨电针治疗原发性痛经大鼠的机制[J].针刺研究,2023,48(12):1258-1265.
[14]TOTH S H,STOICA A D,SEVCENCU C.Redesigning ibuprofen for improved oral delivery and reduced side effects[J].Bioconjug Chem,2025,36(5):893-913.
[15]SAMY A,ABDELHAKIM A M,LATIF D,et al.Benefits of vaginal dinoprostone administration prior to levonorgestrel-releasing intrauterine system insertion in women delivered only by elective cesarean section:A randomized double-blinded clinical trial[J].Arch Gynecol Obstet,2020,301(6):1463-1471.
[16]LIANG L,KUNG J Y,MITCHELMORE B,et al.Comparative peripheral edema for dihydropyridines calcium channel blockers treatment:A systematic review and network meta-analysis[J].J Clin Hypertens,2022,24(5):536-554.
[17]黄栌仪,刘瑞琪,申敏鑫.贺氏针灸三通法配合芬必得治疗原发性痛经临床观察[J].中国中医急症,2023,32(2):288-290.
[18]林宇辰,张幻真,江昌政,等.“按而收之”推拿治疗寒凝血瘀型痛经的机理探析[J].陕西中医,2025,46(12):1659-1662.
[19]周航,陈莹,孙晶.隔药灸联合经痛汤治疗寒凝血瘀型原发性痛经临床观察[J].辽宁中医杂志,2024,51(9):156-159.
[20]BLICHFELDT-ECKHARDT M R,OLSEN D A,ANDERSEN R F,et al.Elevated levels of PGE-2-metabolite in cerebrospinal fluid and Cox-2 gene polymorphisms in patients with chronic,post cholecystectomy pain and visceral hyperalgesia compared to healthy controls[J].A Hypothesis-Generating Pilot Study,J Pain Res,2022,15:3921-3929.
[21]GAO F,HU Q,CHEN W,et al.Brain regulates weight bearing bone through PGE-2 skeletal interoception:Implication of ankle osteoarthritis and pain[J].Bone Res,2024,12(1):16.
[22]徐丹,桂明才,周长华,等.老年突发性耳聋患者血清HMGB1、Cx43、TXB2水平变化及检测意义[J].陕西医学杂志,2025,54(8):1108-1112.
[23]贾小红,巩海亮,宋兰英,等.针刺治疗对原发性痛经患者性激素及前列腺素分泌的调节作用[J].中国医药导报,2016,13(7):76-79.
[24]KACZYNSKI P,BAUERSACHS S,GORYSZEWSKA E,et al.Synergistic action of estradiol and PGE-2 on endometrial transcriptome in vivo resembles pregnancy effects better than estradiol alone[J].Biol Reprod,2021,104(4):818-834.
[25]王瑞琼,王志旺,杜丽东,等.当归有效组分对原发性痛经模型小鼠下丘脑—垂体—卵巢轴的调控作用研究[J].中国临床药理学杂志,2023,39(5):708-712.
[26]唐林峰,聊晓玉,常昊,等.桃红四物颗粒对原发性痛经模型大鼠下丘脑-垂体-卵巢轴功能的影响[J].中南药学,2023,21(10):2659-2666.
[27]赵晓菲,苏心亚,胡菊.温针灸联合四逆汤对寒凝血瘀型原发性痛经患者疼痛介质及免疫功能的影响[J].贵州医药,2023,47(12):1942-1944.
[28]王瑞霞,俞超芹.原发性痛经患者外周血T淋巴细胞亚群的研究[J].实用妇产科杂志,2004,20(4):229-230.

相似文献/References:

[1]纪 珮,陈小平,谢 波.复方左归胶囊治疗卵巢储备功能低下不孕症疗效研究*[J].陕西中医,2019,(3):338.
[2]郭书焕,周艳艳.补肾化痰汤对多囊卵巢不孕症患者卵巢功能、妊娠的影响研究*[J].陕西中医,2019,(2):195.
　GUO Shuhuan,ZHOU Yanyan..Effect of Bushen Huatan decoction on ovarian function and pregnancy in patients with polycystic ovary infertility[J].,2019,(3):195.
[3]王改梅,李 晶,张 励,等.苍附导痰方联合法地兰对PCOS合并不孕症患者性激素水平 及子宫内膜容受性的影响*[J].陕西中医,2019,(2):201.
　WANG Gaimei,LI Jing,ZHANG Li,et al.Effect of Cangfu Daotan prescription combined with Fadiland on sex hormone level and endometrial receptivity in PCOS patients with infertility[J].,2019,(3):201.
[4]李海霞,史秀英,王璀瑛,等.益肾化痰方治疗肥胖型多囊卵巢综合征不孕临床研究[J].陕西中医,2019,(7):839.
　LI Haixia,SHI Xiuying,WANG Cuiying,et al.Clinical study of Yishen Huatan decoction in the treatment of obese polycystic ovarian syndrome infertility[J].,2019,(3):839.
[5]黄 昕,汤春琼△.中医辨证治疗不孕症临床疗效研究[J].陕西中医,2019,(9):1219.
　HUANG Xin,TANG Chunqiong..Effect of TCM syndrome differentiation theory on infertility of different TCM types[J].,2019,(3):1219.
[6]周宇博,吴红斌△.壮医药线点灸对寒湿凝滞型痛经大鼠血栓素B2及血液流变学的影响*[J].陕西中医,2019,(10):1330.
　ZHOU Yubo,WU Hongbin..The effect of mtmz therapy on model of cold damp stagnation type dysmenorrhea rat thromboxane B2 and blood rheology[J].,2019,(3):1330.
[7]王晓莉,刘慧杰,于增瑞,等.柴附青金汤治疗原发性痛经气滞血瘀证疗效研究*[J].陕西中医,2020,(12):1704.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.006]
　WANG Xiaoli,LIU Huijie,YU Zengrui,et al.Efficacy of Chaifu Qingjin decoction in the treatment of primary dysmenorrhea with syndrome of Qizhi Xueyu[J].,2020,(3):1704.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.006]
[8]杜翠忠,张晓静,冯亚宏,等.基于NLRP3/NF-κB/COX-2信号通路探讨痛经胶囊对原发性痛经大鼠的影响[J].陕西中医,2025,46(1):25.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.005]
　DU Cuizhong,ZHANG Xiaojing,FENG Yahong,et al.Based on the NLRP3/NF-κB/COX-2 signal pathway to explore Tongjing capsule pairs effect of primary menstrual pain on rats[J].,2025,46(3):25.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.005]
[9]蒋红根,林真静,许学兵.加味温脐化湿汤联合毫针刺法治疗寒湿凝滞型原发性痛经临床研究[J].陕西中医,2025,46(5):694.[doi:DOI:10.3969/j.issn.1000-7369.2025.05.026]
　JIANG Honggen,LIN Zhenjing,XU Xuebing.Clinical efficacy of modified Wenqi Huashi decoction combined with Bo acupuncture in the treatment of primary dysmenorrhea of cold-dampness stagnation type[J].,2025,46(3):694.[doi:DOI:10.3969/j.issn.1000-7369.2025.05.026]
[10]严海兵,刘顺,杨秀珍.健脾益肾化浊方联合二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗疗效及对患者性激素和糖脂代谢的影响[J].陕西中医,2025,46(9):1193.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.008]
　YAN Haibing,LIU Shun,YANG Xiuzhen.Effects of Jianpi Yishen Huazhuo formula combined with metformin on efficacy,sex hormones,and glucose-lipid metabolism in patients with polycystic ovary syndrome complicated by insulin resistance[J].,2025,46(3):1193.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.008]

备注/Memo

备注/Memo:
四川省中医药管理局科学技术研究专项课题（2023MS157）
更新日期/Last Update: 2026-03-05