[1]杨济瑜,王颖.淫羊藿活性成分对女性生殖内分泌调节作用的研究进展[J].陕西中医,2026,(3):420.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.026]
　YANG Jiyu,WANG Ying.Research progress on the regulatory effects of epimedium active components on female reproductive endocrine function[J].,2026,(3):420.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.026]
点击复制

淫羊藿活性成分对女性生殖内分泌调节作用的研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
420
栏目:
综 述
出版日期:
2026-03-05

文章信息/Info

Title:
Research progress on the regulatory effects of epimedium active components on female reproductive endocrine function
作者:
杨济瑜1; 王颖2
（1.黑龙江中医药大学研究生院，黑龙江 哈尔滨 150040;2.黑龙江中医药大学附属第一医院妇科二科,黑龙江 哈尔滨 150040）
Author(s):
YANG Jiyu1; WANG Ying2
（1.Graduate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;2.Department Two of Gynecology,First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China）
关键词:
淫羊藿; 女性生殖内分泌; 类雌激素; 类固醇; 子宫内膜血管; 卵巢纤维化
Keywords:
Epimedium; Female reproductive endocrinology; Estrogen-like substances; Steroids;  Endometrial vessels; Ovarian fibrosis
分类号:
R 711.5
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.026
文献标志码:
A
摘要:
淫羊藿活性成分具有类雌激素作用，可改善雌激素相关的子宫内膜功能。淫羊藿活性成分可调节下丘脑-垂体-卵巢轴功能，调节性激素的分泌，促进内分泌平衡。淫羊藿活性成分可促进卵巢颗粒细胞类固醇生成，促进雌激素和孕酮的生成。淫羊藿活性成分可保护卵巢结构和功能，维持生殖内分泌稳态。淫羊藿活性成分调节子宫内膜血管功能，促进血管生成以增强内膜修复，还可抑制过度血管生成，改善血管通透性。淫羊藿活性成分可抑制卵巢纤维化，解除卵泡闭锁，提高卵巢储备功能。淫羊藿活性成分直接刺激卵巢颗粒细胞增殖，促进卵泡发育。淫羊藿活性成分可抑制卵巢颗粒细胞和子宫内膜基质细胞的凋亡，维持生殖功能稳定。淫羊藿活性成分通过提升抗氧化酶和信号通路活性，减轻卵巢组织氧化应激损伤。
Abstract:
Epimedium active components have estrogen-like effects and can improve estrogen-related endometrial function.Epimedium active components can regulate the hypothalamus-pituitary-ovarian axis,regulate sex hormone secretion,and promote endocrine balance.Epimedium active components can promote steroid production in ovarian granulosa cells,and promote the production of estrogen and progesterone.Epimedium active components can protect ovarian structure and function,and maintain reproductive endocrine homeostasis.Epimedium active components regulate endometrial vascular function,promote angiogenesis to enhance endometrial repair,and can also inhibit excessive angiogenesis and improve vascular permeability.Epimedium active components can inhibit ovarian fibrosis,relieve follicular atresia,and improve ovarian reserve.Epimedium active components directly stimulate the proliferation of ovarian granulosa cells and promote follicular development.Epimedium active components can inhibit apoptosis of ovarian granulosa cells and endometrial stromal cells,and maintain reproductive function stability.Epimedium active ingredients reduce oxidative stress damage to ovarian tissue by enhancing the activity of antioxidant enzymes and signaling pathways.

参考文献/References:

[1]郁琦,韩晓洁.2022年女性生殖内分泌领域研究进展[J].中国实用妇科与产科杂志,2023,39(1):39-42.
[2]段娟,刘莱莱.性发育与性早熟的中医认识及辨治思路[J].环球中医药,2022,15(11):2189-2193.
[3]王月娇,归雯佳,丛超,等.肝脾论治多囊卵巢综合征探析[J].陕西中医,2021,42(10):1442-1444.
[4]葛航,常惠,王宇,等.初潮年龄与育龄期多囊卵巢综合征不孕患者中医证型和生殖内分泌特征的关系[J].中华中医药杂志,2024,39(2):962-967.
[5]马青,王东梅.淫羊藿在妇科疾病中的应用[J].吉林中医药,2017,37(1):78-81.
[6]薛佳,陈海杰.淫羊藿不同部位多元活性成分的分析与评价[J].中国中药杂志,2023,48(13):3448-3461.
[7]韩洁,刘子怡,方振,等.重复制动应激对雌性大鼠下丘脑-垂体-卵巢轴的影响[J].中国应用生理学杂志，2020,36(3):245-249.
[8]于燕,颜虹.淫羊藿提取物的雌激素样作用研究[J].西安交通大学学报(医学版),2009,30(3):373-376.
[9]LE A W,SHAN L,WANG Z H,et al.Effects of icariin on the expression of ER,VEGF,and KDR in the endometrial cells of endometrium[J].Genet Mol Res,2015,14(3):11250-11258.
[10]MUNERI C W,AFEDO S Y,YAPING X,et al.Icariin impacts molecular changes in estrogen receptors but not other reproductive parameters in female mice[J].Indian Journal of Animal Research,2019,53(4):451-456.
[11]张璇,刘佳欣,夏晨,等.基于GnRH及其受体介导下丘脑-垂体-卵巢轴探讨温和灸干预妇科寒凝血瘀证作用机制[J].中国中医药信息杂志,2025,32(2):113-119.
[12]ZUO L,HAI Y,ZHANG R,et al.Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome[J].European Journal of Pharmacology,2023,953:175825.
[13]徐彩生,罗丽莉,曾如辉,等.淫羊藿总黄酮对多囊卵巢综合征大鼠性激素水平的影响[J].重庆医科大学学报，2013,38(2):147-150.
[14]张玉昆,牛雯颖,姜广坤,等.淫羊藿对雌性大鼠双侧卵巢摘除模型的影响[J].中医药学报,2016,44(3):24-26.
[15]LI N,WANG J,WANG X,et al.Icariin exerts a protective effect against d-galactose induced premature ovarian failure via promoting DNA damage repair[J].Biomedicine & Pharmacotherapy,2019,118:109218.
[16]CHEN H R,SONG L J,XU X F,et al.The effect of icariin on autoimmune premature ovarian insufficiency via modulation of Nrf2/HO-1/Sirt1 pathway in mice[J].Reproductive Biology,2022,22(2):100638.
[17]何晓,沈豪飞,姚莹,等.MicroRNA调控卵巢颗粒细胞功能的研究进展[J].中国计划生育和妇产科,2021,13(9):57-60.
[18]YANG L J,LU D F,GUO J J,et al.Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)[J].Journal of Ethnopharmacology,2013,145(3):715-721.
[19]NIE X W,SHENG W J,HOU D R,et al.Effect of Hyperin and Icariin on steroid hormone secretion in rat ovarian granulosa cells[J].Clinica Chimica Acta,2019,495:646-651.
[20]薛美昭,赵均.淫羊藿苷对环磷酰胺致小鼠卵巢早衰的影响[J].中国中医药信息杂志,2023,30(4):106-110.
[21]魏铭媛,高丽娟,王希,等.多囊卵巢综合征脑结构、功能异常及其与精神障碍的相关性研究进展[J].江苏大学学报（医学版),2024,34(5):451-455.
[22]董若曦,朱小丹,樊伯珍,等.淫羊藿苷对顺铂致卵巢早衰大鼠卵巢储备功能的作用研究[J].浙江医学，2019,41(3):230-233.
[23]王小洁,张云锋,张彦敏.淫羊藿苷基于GDF-9/Smads对多囊卵巢小鼠排卵的作用[J].西北药学杂志，2023,38(5):65-70.
[24]何燕妮,刘红梅.子宫内膜血管生成与血流灌注指标在评价子宫内膜容受性中的价值[J].中国实用妇科与产科杂志，2012,28(12):958-960.
[25]LE A W,WANG Z H.An experimental study on the use of icariin for improving thickness of thin endometrium[J].Genet Mol Res,2017,16(1):4210-4238.
[26]李玉琴,郭红,俄洛吉,等.淫羊藿苷对E2诱发去势大鼠子宫内膜渗出的干预作用研究[J].中国妇幼保健，2016,31(5):1039-1041.
[27]李冰冰,刘雁峰,王铁枫,等.从“肾阳虚,肝脉寒伏”辨治卵巢巧克力囊肿纤维化[J].中华中医药杂志，2019,34(5):2208-2211.
[28]LI Q F,XIAO Z L.Effect of icariin on the number of Follicles and endometrium thickness in mice with premature ovarian failure[J].Clinical and Experimental Obstetrics & Gynecology,2024,51(8):175.
[29]徐亚萍.淫羊藿苷和淫羊藿多糖对卵泡发育与抗氧化作用的影响[D].南京：南京农业大学,2016.
[30]马会明,黑常春,张永芳,等.EGF通过PI3K/AKT通路介导小鼠卵巢颗粒细胞增殖[J].宁夏医科大学学报，2014,36(5):483-486.
[31]徐亚萍,陈佳慧,刘萌萌,等.淫羊藿苷对小鼠卵泡卵母细胞体外发育与成熟的影响[J].畜牧与兽医，2016,48(5):105-107.
[32]王雪金,周云清,罗湘闽,等.邻苯二甲酸二丁酯对大鼠卵巢颗粒细胞中细胞凋亡因子Bcl-2、Bax表达的影响[J].实用预防医学,2015,22(2):155-158.
[33]蔺会兰,孙晓慧,刘俊霞,等.Bcl-2与卵巢颗粒细胞凋亡相关性研究[J].河北医药,2015,37(9):1316-1319.
[34]LI F F,ZHU F Y,WANG S Y,et al.Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway[J].Scientific Reports,2024,14(1):17318.
[35]徐琼芳,钟斐,李子帅.淫羊藿苷调节SDF-1/CXCR4信号通路对多囊卵巢综合征大鼠卵巢颗粒细胞凋亡的影响[J].天津医药,2024,52(7):727-732.
[36]邵梅,王家传.淫羊藿素对多囊卵巢综合征颗粒细胞凋亡和自噬的影响[J].中国临床药理学杂志，2021,37(20):2830-2833.
[37]LE A,WANG Z H,DAI X Y,et al.Icaritin inhibits decidualization of endometrial stromal cells[J].Experimental and Therapeutic Medicine,2017,14(6):5949-5955.
[38]洪芳青,方海娅,林平.氧化应激指标在中重度卵巢子宫内膜异位症发病中的作用及诊断效能研究[J].中国性科学,2022,31(6):87-91.

相似文献/References:

[1]董若曦,朱小丹,张 越,等.淫羊藿及其主要成分在卵巢早衰治疗中的应用进展*[J].陕西中医,2019,(5):678.

备注/Memo

备注/Memo:
国家自然科学基金资助面上项目（82374498）；国家中医药传承创新团队项目（ZYYCXTD-C-202404）；龙江科技英才春雁支持计划项目（2022CYCX0026）；黑龙江中医药管理局青年中医药科研课题（ZHY2023-206）；黑龙江中医药大学研究生创新科研项目（2024yjscx012）
更新日期/Last Update: 2026-03-05