[1]尹诗晴,刘旭成,杨维杰.中药调控 AMPK 信号通路干预肥胖的研究进展[J].陕西中医,2026,(3):424.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.027]
　YIN Shiqing,LIU Xucheng,YANG Weijie.Research progress on the regulation of AMPK signaling pathway by traditional Chinese medicine in the intervention of obesity[J].,2026,(3):424.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.027]
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中药调控 AMPK 信号通路干预肥胖的研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
424
栏目:
综 述
出版日期:
2026-03-05

文章信息/Info

Title:
Research progress on the regulation of AMPK signaling pathway by traditional Chinese medicine in the intervention of obesity
作者:
尹诗晴1; 刘旭成1; 杨维杰2
（1.甘肃中医药大学研究生院，甘肃 兰州 730000；2.甘肃中医药大学附属医院内分泌科，甘肃 兰州 730000）
Author(s):
YIN Shiqing1; LIU Xucheng1; YANG Weijie2
(1.Graduate School,Gansu University of Chinese Medicine,Lanzhou 730000,China;2.Department of Endocrinology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)
关键词:
中药; AMPK信号通路; 肥胖; 脂肪代谢; 中药活性成分; 中药复方
Keywords:
Traditional Chinese medicine; AMPK signaling pathway; Obesity; Fat metabolism; Active components of traditional Chinese medicine; Traditional Chinese medicine formulas
分类号:
R 723.14
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.027
文献标志码:
A
摘要:
肥胖是全球面临的重大公共卫生挑战，与多种代谢综合征密切相关。AMPK作为细胞能量代谢的核心调控因子，在脂质合成、分解及能量平衡中发挥着关键作用，是肥胖治疗的潜力靶点。然而，现有化学药物在靶向AMPK通路时仍存在选择性不足、不良反应明显等局限。中药凭借其“多成分-多靶点-多通路”的整体调节优势，为AMPK通路的精准调控提供了新策略。数据表明，多种中药活性成分、提取物及复方能够通过激活AMPK及其下游信号，进而发挥多效抗肥胖作用，包括：抑制脂肪生成、促进脂肪酸氧化、调节能量代谢和改善胰岛素敏感性。此外，中药在与生活方式干预或西药联合应用时，也显示出协同代谢调节与减重增效的潜力。本文系统综述了AMPK在脂肪代谢中的调控机制，重点探讨中药通过AMPK通路干预肥胖的研究进展，并对未来转化研究方向作出展望，以期为肥胖的防治提供新思路与理论依据。
Abstract:
Obesity is a major public health challenge worldwide and is closely related to various metabolic syndromes.AMPK serves as a core regulator of cellular energy metabolism and plays a crucial role in lipid synthesis,decomposition,and energy balance,making it a potential target for obesity treatment.However,existing chemical drugs still have limitations such as insufficient selectivity and obvious side effects when targeting the AMPK pathway.Traditional Chinese medicine,with its advantage of "multi-component-multi-target-multi-pathway" overall regulation,provides a new strategy for the precise regulation of the AMPK pathway.Data show that many active components,extracts,and formulas of traditional Chinese medicine can exert multiple anti-obesity effects by activating AMPK and its downstream signals,including:inhibiting fat synthesis,promoting fatty acid oxidation,regulating energy metabolism,and improving insulin sensitivity.Moreover,traditional Chinese medicine also shows potential for synergistic metabolic regulation and weight loss enhancement when combined with lifestyle intervention or Western medicine.This article systematically reviews the regulatory mechanism of AMPK in fat metabolism,focuses on the research progress of traditional Chinese medicine in the intervention of obesity through the AMPK pathway,and makes prospects for future translational research directions,in order to provide new ideas and theoretical basis for the prevention and treatment of obesity.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（8216150429）；甘肃省自然科学基金资助项目（22JR5RA607）
更新日期/Last Update: 2026-03-05