[1]贺屹巍,刘毅,李玮,等.八珍汤加减对腹腔镜胃癌根治术后患者肠道菌群、胃肠激素及免疫功能的影响[J].陕西中医,2026,(4):502-506.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.013]
　HE Yiwei,LIU Yi,LI Wei,et al.Effects of modified Bazhen decoction on intestinal flora,gastrointestinal hormones and immune function in patients after laparoscopic radical gastrectomy for gastric cancer[J].,2026,(4):502-506.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.013]
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八珍汤加减对腹腔镜胃癌根治术后患者肠道菌群、胃肠激素及免疫功能的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
502-506
栏目:
临床研究
出版日期:
2026-04-05

文章信息/Info

Title:
Effects of modified Bazhen decoction on intestinal flora,gastrointestinal hormones and immune function in patients after laparoscopic radical gastrectomy for gastric cancer
作者:
贺屹巍1; 刘毅2; 李玮1; 刘艳凤1; 申立中1; 李洪超3
（1.河北省中医院消化外科，河北 石家庄 050013；2.河北省深州市中西医结合医院外科，河北 深州 053800；3.河北省中医院肛肠科，河北 石家庄 050013）
Author(s):
HE Yiwei1; LIU Yi2; LI Wei1; LIU Yanfeng1; SHEN Lizhong1; LI Hongchao3
（1.Department of Gastrointestinal Surgery,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050013,China；2.Department of Surgery,Shenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhou 053800,China；3.Department of Anorectal Diseases,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050013,China）
关键词:
八珍汤; 腹腔镜胃癌根治术; 胃肠激素; 免疫功能; 肠道菌群; 胃肠功能
Keywords:
Bazhen decoction; Laparoscopic radical gastrectomy for gastric cancer; Gastrointestinal hormones; Immune function; Intestinal flora; Gastrointestinal function
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7369.2026.04.013
文献标志码:
A
摘要:
目的：观察八珍汤加减对腹腔镜胃癌根治术后患者肠道菌群、胃肠激素及免疫功能的影响。方法：选取择期行腹腔镜胃癌根治术的患者106例，采用信封法随机分为两组。对照组术后仅给予常规对症治疗，试验组在对照组基础上给予八珍汤加减治疗，连续治疗2周。记录两组一般情况、不良反应率，比较两组治疗前后胃肠激素水平、肠道菌群丰度、免疫功能指标、中医证候评分。结果：试验组肠鸣音恢复时间、首次排气时间、首次排便时间短于对照组（均P<0.05）。两组治疗后胃泌素、胃动素、血管活性肠肽、CD4+、CD4+/CD8+较治疗前升高（均P<0.05），试验组胃泌素、胃动素、血管活性肠肽、CD4+、CD4+/CD8+高于对照组（均P<0.05）。两组治疗后CD8+及中医证候评分较治疗前降低（均P<0.05），试验组CD8+及中医证候评分低于对照组（均P<0.05）。两组治疗后Ace指数、Chao指数及坚壁菌门、拟杆菌门、放线菌门水平相对丰度较治疗前升高（均P<0.05），试验组Ace指数、Chao指数及坚壁菌门、拟杆菌门、放线菌门水平相对丰度显著高于对照组（均P<0.05）。两组治疗后变形菌门水平相对丰度较治疗前降低（均P<0.05），试验组变形菌门水平相对丰度显著低于对照组（均P<0.05）。两组治疗前后Shannon指数、Simpson指数比较差异均无统计学意义（均P>0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：八珍汤加减可改善腹腔镜胃癌根治术后患者胃肠激素和免疫功能，调节肠道菌群，促进术后胃肠功能恢复。
Abstract:
Objective：To observe the effects of the addition and subtraction of Bazhen decoction on intestinal flora,gastrointestinal hormones and immune function of patients after laparoscopic radical gastric cancer surgery.Methods:A total of 106 patients undergoing elective laparoscopic gastrectomy for gastric cancer were selected and randomly divided into two groups using the envelope method.The control group received only conventional symptomatic treatment postoperatively,while the experimental group received Baizhen decoction plus additional treatment based on the control group,with continuous treatment for 2 weeks.Record the general conditions and adverse reaction rates of the two groups,and compare the levels of gastrointestinal hormones,intestinal flora abundance,immune function indicators,and traditional Chinese medicine syndrome scores of the two groups before and after treatment.Results:The recovery time of bowel sounds,the time of first exhaust,and the time of first defecation in the experimental group were shorter than those in the control group (all P<0.05).After treatment,the levels of gastrin,motilin,vasoactive intestinal peptide,CD4+,and CD4+/CD8+ in both groups were higher than those before treatment (all P<0.05),and the levels of gastrin,motilin,vasoactive intestinal peptide,CD4+,and CD4+/CD8+ in the experimental group were higher than those in the control group (all P<0.05).After treatment,the levels of CD8+ and the scores of traditional Chinese medicine syndromes in both groups were lower than those before treatment (all P<0.05),and the levels of CD8+ and the scores of traditional Chinese medicine syndromes in the experimental group were lower than those in the control group (all P<0.05).After treatment,the relative abundances of the Ace index,Chao index,and the levels of Firmicutes,Bacteroidetes,and Actinobacteria in both groups were higher than those before treatment (all P<0.05),and the relative abundances of the Ace index,Chao index,and the levels of Firmicutes,Bacteroidetes,and Actinobacteria in the experimental group were significantly higher than those in the control group (all P<0.05).After treatment,the relative abundance of Proteobacteria in both groups was lower than that before treatment (all P<0.05),and the relative abundance of Proteobacteria in the experimental group was significantly lower than that in the control group (all P<0.05).There were no significant differences in the Shannon index and Simpson index between the two groups before and after treatment (all P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The modified Bazhen decoction can improve gastrointestinal hormone and immune function,regulate intestinal flora,and promote the recovery of postoperative gastrointestinal function in patients after laparoscopic radical gastric cancer surgery.

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备注/Memo

备注/Memo:
河北省中医药管理局科研计划项目（2022044）
更新日期/Last Update: 2026-04-05