[1]左佳倩,束昕妍,黄玉洁,等.基于自噬探讨中药活性成分调节肿瘤微环境发挥抗肿瘤作用的研究进展[J].陕西中医,2026,(4):563-567.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.026]
　ZUO Jiaqian,SHU Xinyan,HUANG Yujie,et al.Research progress on the role of active ingredients in traditional Chinese medicine in regulating the tumor microenvironment and exerting anti-tumor effects based on autophagy[J].,2026,(4):563-567.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.026]
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基于自噬探讨中药活性成分调节肿瘤微环境发挥抗肿瘤作用的研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
563-567
栏目:
综 述
出版日期:
2026-04-05

文章信息/Info

Title:
Research progress on the role of active ingredients in traditional Chinese medicine in regulating the tumor microenvironment and exerting anti-tumor effects based on autophagy
作者:
左佳倩1; 2; 束昕妍1; 2; 黄玉洁1; 2; 任雯沁1; 2; 舒鹏1; 2
（1.南京中医药大学附属医院，江苏 南京 210029；2.南京中医药大学，江苏 南京 210000)
Author(s):
ZUO Jiaqian1; 2; SHU Xinyan1; 2; HUANG Yujie1; 2; REN Wenqin1; 2; SHU Peng1; 2
（1.Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029，China;2.Nanjing University of Chinese Medicine,Nanjing 210000，China）
关键词:
肿瘤微环境; 自噬; 肿瘤转移; 免疫功能; 程序性死亡因子1
Keywords:
Tumor microenvironment; Autophagy; Tumor metastasis; Immune function; Programmed death receptor 1
分类号:
R 73
DOI:
DOI:10.3969/j.issn.1000-7369.2026.04.026
文献标志码:
A
摘要:
在肿瘤的发生和发展过程中，癌症细胞与周围的微环境相互作用共同推动肿瘤的进展。自噬作为机体的一种调节机制，在肿瘤微环境中发挥的作用复杂且多面，对肿瘤的治疗、进展会产生不同影响。中医药治疗对于肿瘤细胞自噬具有增强、抑制或双向调控等多重作用，它可以重塑肿瘤微环境，防治肿瘤的转移复发。通过总结近年来中医药通过调控自噬重塑肿瘤微环境以发挥抗肿瘤作用的相关文献，探讨相关分子机制，以期为后期新型治疗策略的研发提供重要的理论基础。
Abstract:
During the development and progression of tumors,cancer cells interact with the surrounding microenvironment,collectively promoting tumor progression.Autophagy,as a self-regulatory mechanism of the body,plays a complex and multifaceted role in the tumor microenvironment,exerting varying effects on tumor treatment and progression.Traditional Chinese medicine (TCM) exerts multiple effects including enhancing,inhibiting,or bidirectionally regulating tumor cell autophagy.Additionally,it can reshape the tumor-associated microenvironment and help prevent tumor metastasis and recurrence.By reviewing recent literature on TCM-mediated autophagy regulation and tumor microenvironment remodeling in cancer treatment,this study explores the underlying molecular mechanisms,providing an important theoretical foundation for the future development of novel therapeutic strategies.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374539）；江苏省中医药科技发展计划重点项目（ZD202214）；江苏省中医药领军人才培养对象项目（SLJ0327）；南京中医药大学胃癌临床专病研究院项目（LCZBYJYZZ2024-001）
更新日期/Last Update: 2026-04-05