[1]杨玉祥,吕 浩,竺应浩,等.杜仲补肾方治疗椎间盘退变性腰痛临床研究[J].陕西中医,2026,(5):619-624.[doi:DOI:10.3969/j.issn.1000-7369.2026.05.007]
 YANG Yuxiang,LYU Hao,ZHU Yinghao,et al.Clinical study on treatment of lumbar pain caused by intervertebral disc degeneration with Duzhong Bushen formula[J].,2026,(5):619-624.[doi:DOI:10.3969/j.issn.1000-7369.2026.05.007]
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杜仲补肾方治疗椎间盘退变性腰痛临床研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年5期
页码:
619-624
栏目:
临床研究
出版日期:
2026-05-05

文章信息/Info

Title:
Clinical study on treatment of lumbar pain caused by intervertebral disc degeneration with Duzhong Bushen formula
作者:
杨玉祥1吕 浩1竺应浩1刘 强1衣海茹1王 毅1江 渟2
(1.安徽中医药大学第一临床医学院,安徽 合肥 230031;2.安徽中医药大学第一附属医院,安徽 合肥 230031)
Author(s):
YANG Yuxiang1LYU Hao1ZHU Yinghao1LIU Qiang1YI Hairu1WANG Yi1JIANG Ting2
(1.First Clinical Medical College,Anhui University of Chinese Medicine,Hefei 230031,China;2.The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)
关键词:
杜仲补肾方腰痹通胶囊椎间盘退变性腰痛肾虚血瘀证新安医学炎症
Keywords:
Duzhong Bushen formulaYaobitong capsuleDegenerative discogenic low back painShenxu Xueyu syndromeXin’an medical schoolInflammatory factors
分类号:
R274
DOI:
DOI:10.3969/j.issn.1000-7369.2026.05.007
文献标志码:
A
摘要:
目的:探讨杜仲补肾方对椎间盘退变性腰痛的临床疗效。方法:收集98例椎间盘退变性腰痛患者的病历资料开展回顾性研究。根据用药方案不同,将患者分为观察组50例、对照组48例。对照组患者口服腰痹通胶囊1.26 g/次,3次/d。观察组则采用杜仲补肾方随证加减治疗,两组疗程均为8周。比较治疗前后两组的临床总有效率、C反应蛋白(CRP)、血沉(ESR)、白介素6(IL-6)、超氧化物歧化酶(SOD)、磁共振成像T2加权像信号相对值,并进行临床功能评分,疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、罗兰-莫里斯功能障碍调查问卷(RMDQ),临床疗效评估。结果:观察组总有效率为90.00%,高于对照组的72.92%(P<0.05)。两组治疗后CRP、ESR、IL-6均较治疗前下降,SOD较前升高(P<0.05),且观察组各指标改善程度均优于对照组(P<0.05)。治疗后,两组的VAS、ODI及RMDQ评分均下降,且观察组各项评分均低于对照组(P<0.05)。MRI-T2WI信号相对值在两组治疗后均有提升,观察组提升幅度大于对照组(P<0.05)。结论:杜仲补肾方加减治疗椎间盘退变性腰痛,能有效减轻患者疼痛、改善功能状态,同时抑制炎症反应并提升抗氧化能力,临床疗效较好。
Abstract:
Objective:To explore clinical efficacy of modified Duzhong Bushen formula in the treatment of lumbar pain due to intervertebral disc degeneration.Methods:A retrospective study was conducted on the medical records of 98 patients with lumbar pain due to intervertebral disc degeneration.The patients were divided into observation group (50 cases) and control group (48 cases) based on different treatment regimens.The control group was treated with oral administration of Yaobitong capsules at a dose of 1.26 g each time,three times a day.The observation group was treated with modified Duzhong Bushen formula based on syndrome differentiation.Both groups were treated for 8 weeks.The total clinical effective rate,C-reactive protein (CRP),erythrocyte sedimentation rate (ESR),interleukin-6 (IL-6),superoxide dismutase (SOD),and the relative value of T2-weighted imaging signal intensity on magnetic resonance imaging (MRI-T2WI) were compared before and after treatment.Clinical function scores,visual analogue scale(VAS) for pain,oswestry disability index (ODI),and roland-morris disability questionnaire (RMDQ) were also evaluated.Results:The total effective rate of the observation group was 90.00%,which was higher than that the control group 72.92%(P<0.05).After treatment,CRP,ESR,and IL-6 levels decreased,while SOD levels increased in both groups (P<0.05),and the improvement in the observation group was better than that in the control group (P<0.05).After treatment,VAS,ODI and RMDQ scores decreased in both groups,and the scores in the observation group were lower than those in the control group (P<0.05).The relative value of MRI-T2WI signal intensity increased in both groups after treatment,and increase in the observation group was greater than that in the control group (P<0.05).Conclusion:The modified Duzhong Bushen formula can effectively relieve pain,improve functional status,inhibit inflammatory responses,and enhance antioxidant capacity in patients with lumbar pain due to intervertebral disc degeneration,demonstrating good clinical efficacy.

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备注/Memo

备注/Memo:
安徽省自然科学基金资助面上项目(2308085MH294);安徽省重点研究与计划开发项目(202104J07020010);安徽省教育厅自然科学研究重点项目(2022AH050510);安徽省中医药传承创新科研项目(2024ZYYXH010)
更新日期/Last Update: 2026-05-05