[1]韩 杰,祁浩然,刘 琪.益气蠲饮方联合左西孟旦治疗慢性心力衰竭疗效研究[J].陕西中医,2026,(5):630-634.[doi:DOI:10.3969/j.issn.1000-7369.2026.05.009]
　HAN Jie,QI Haoran,LIU Qi.Study on therapeutic effect of Yiqi Juanyin formula combined with levosimendan on chronic heart failure[J].,2026,(5):630-634.[doi:DOI:10.3969/j.issn.1000-7369.2026.05.009]
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益气蠲饮方联合左西孟旦治疗慢性心力衰竭疗效研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年5期
页码:
630-634
栏目:
临床研究
出版日期:
2026-05-05

文章信息/Info

Title:
Study on therapeutic effect of Yiqi Juanyin formula combined with levosimendan on chronic heart failure
作者:
韩 杰; 祁浩然; 刘 琪
（石家庄市中医院，河北 石家庄 050000）
Author(s):
HAN Jie; QI Haoran; LIU Qi
(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)
关键词:
慢性心力衰竭; 左西孟旦; 中药; 血管内皮功能; 心功能; 运动耐力; 心肌损伤
Keywords:
Chronic heart failure; Levosimendan; Traditional Chinese medicine; Vascular endothelial function; Cardiac function; Physical endurance; Myocardial injury
分类号:
R541.6
DOI:
DOI:10.3969/j.issn.1000-7369.2026.05.009
文献标志码:
A
摘要:
目的：探讨益气蠲饮方联合左西孟旦对慢性心力衰竭（CHF）干预的效果，及对患者心功能、血管内皮功能等的影响。方法：选择本院CHF患者90例，依据随机数字表法分为对照组45例、研究组45例。在常规治疗基础上，对照组采用左西孟旦治疗，研究组在西药基础上联合益气蠲饮方治疗。持续干预1个月后，比较两组中医证候积分、心功能、心肌损伤指标、血管内皮功能、总有效率、运动耐力及不良反应。结果：治疗后，研究组肌酸激酶同工酶（CK-MB）、证候总分、左室舒张末期内径（LVEDD）、心肌肌钙蛋白I（cTnI）、内皮素-1（ET-1）、N末端脑钠肽前体（NT-proBNP）水平低于对照组（均P＜0.05）。研究组左心室射血分数（LVEF）、一氧化氮（NO）、6 min内步行距离（6MWD）、心排血量（CO）均高于对照组（均P＜0.05）。研究组总有效率（91.11%）高于对照组（75.56%），差异有统计学意义（P＜0.05）。研究组与对照组恶心呕吐、低血压等不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：CHF患者接受益气蠲饮方联合左西孟旦干预，可有效纠正血管内皮功能，增强心脏射血能力，抑制病情进展，对患者运动耐力恢复具有良好促进作用，且安全性较好。
Abstract:
Objective:To explore intervention effects of Yiqi Juanyin formula and levosimendan on intervention of chronic heart failure (CHF),as well as their influences on patients' cardiac function and vascular endothelial function.Methods:90 patients with CHF in hospital were screened according to inclusion and exclusion criteria.They were divided into control group (45 cases) and study group (45 cases) based on random number table method.On the basis of conventional treatment,the control group adopted levosimendan,while the test group adopted the combination of Yiqi Juanyin formula.After continuous intervention for one month,traditional Chinese medicine syndrome,cardiac function,myocardial injury indicators,vascular endothelial function,total effective rate,exercise endurance and adverse reactionswere compared.Results:After medication,the test group had prominently lower creatine kinase isoenzymes (CK-MB),total syndrome score,left ventricular end diastolic diameter (LVEDD),cardiac troponin I (cTnI),endothelin-1 (ET-1),and N-terminal pro brain natriuretic peptide (NT-proBNP) than the control group (all P＜0.05).The test group had prominently higher left ventricular ejection fraction (LVEF),nitric oxide (NO),6-minute walking distance (6MWD),and cardiac output (CO) than the control group (all P＜0.05).Comparing overall effective rate,the test group was prominently higher than the control group （91.11% vs.75.56%），differences statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions such as nausea,vomiting,and hypotension between the study group and control group (P＞0.05).Conclusion:The intervention of Yiqi Juanyin formula combined with levosimendan can effectively correct vascular endothelial function,enhance cardiac ejection ability,inhibit disease progression,and promote the recovery of exercise endurance in CHF patients， moreover and better safy.

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备注/Memo

备注/Memo:
河北省中医药管理局中医药类科学研究课题（2025096）
更新日期/Last Update: 2026-05-05