[1]张婷,王迎春,朱慧芳,等.加味少腹逐瘀汤联合布洛芬治疗寒凝血瘀型原发性痛经临床研究[J].陕西中医,2026,(6):782-786.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.011]
 ZHANG Ting,WANG Yingchun,ZHU Huifang,et al.Clinical study on modified Shaofu Zhuyu decoction combined with ibuprofen for primary dysmenorrhea of cold coagulation and blood stasis type[J].,2026,(6):782-786.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.011]
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加味少腹逐瘀汤联合布洛芬治疗寒凝血瘀型原发性痛经临床研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
782-786
栏目:
临床研究
出版日期:
2026-06-05

文章信息/Info

Title:
Clinical study on modified Shaofu Zhuyu decoction combined with ibuprofen for primary dysmenorrhea of cold coagulation and blood stasis type
作者:
张婷1王迎春2朱慧芳2沈宏杰3
(1.北京市第六医院,北京 100007; 2.廊坊卫生职业学院,河北 廊坊 065001;3.廊坊市广阳区妇幼保健院,河北 廊坊 065000)
Author(s):
ZHANG Ting1WANG Yingchun2ZHU Huifang2SHEN Hongjie3
(1.Beijing Sixth Hospital,Beijing 100007,China;2.Langfang Health Vocational College,Langfang 065001,China;3.Langfang Guangyang District Maternal and Child Health Care Hospital,Langfang 065000,China)
关键词:
寒凝血瘀型原发性痛经加味少腹逐瘀汤布洛芬疼痛程度 5-羟色胺β-内啡肽前列腺素 E2环磷酸腺苷/蛋白激酶 A信号通路
Keywords:
Cold coagulation and blood stasis type primary dysmenorrheaModified Shaofu Zhuyu decoctionIbuprofenPain degree5-hydroxytryptamineβ-endorphinProstaglandin E2Cyclic Adenosine Monophosphate/Protein Kinase A signaling pathway
分类号:
R 271.113
DOI:
DOI:10.3969/j.issn.1000-7369.2026.06.011
文献标志码:
A
摘要:
目的:探讨加味少腹逐瘀汤联合布洛芬对寒凝血瘀型原发性痛经患者5-羟色胺(5-HT)、β-内啡肽(β-EP)、前列腺素 E2(PGE2)水平、环磷酸腺苷(cAMP)/蛋白激酶 A(PKA)信号通路的影响。方法:采用随机数字表法将130例血瘀型原发性痛经患者分为对照组和治疗组各65例,对照组给予布洛芬治疗,治疗组在对照组治疗基础上给予加味少腹逐瘀汤。对比两组疗效,统计两组治疗前后中医症候积分、VAS评分、5-HT、β-EP、PGE2水平、cAMP/PKA信号通路。结果:治疗组总有效率高于对照组(P<0.05)。治疗前,两组得温则痛势缓解、经前或经期小腹冷痛、畏寒肢冷、拒按、经期推迟、经血色暗伴血块、面色青白、白带增多、乳房或胸胁胀痛评分、VAS评分、5-HT、β-EP、PGE2水平、cAMP、PKA mRNA水平比较无统计学差异(P>0.05);治疗后,两组中医症候积分、VAS评分、5-HT水平、cAMP、PKA mRNA水平低于治疗前,β-EP、PGE2水平高于治疗前,治疗组得温则痛势缓解、经前或经期小腹冷痛、畏寒肢冷、拒按、经期推迟、经血色暗伴血块、面色青白、白带增多、乳房或胸胁胀痛评分、VAS评分、5-HT水平、cAMP、PKA mRNA水平低于对照组,β-EP、PGE2水平高于对照组(P<0.05)。结论:寒凝血瘀型原发性痛经患者采用加味少腹逐瘀汤联合布洛芬治疗,可提高β-EP、PGE2水平,降低5-HT水平,抑制cAMP/PKA信号通路,从而发挥缓解疼痛的作用。
Abstract:
Objective:To explore the effects of modified Shaofu Zhuyu decoction combined with ibuprofen on the levels of 5-hydroxytryptamine (5-HT),β-endorphin (β-EP),prostaglandin E2 (PGE2),and the cAMP/PKA signaling pathway in patients with primary dysmenorrhea of cold-stagnation blood stasis type.Methods:Using the random number table method,130 patients with blood stasis type primary dysmenorrhea were divided into a control group and a treatment group,with 65 cases in each group.The control group was treated with ibuprofen,while the treatment group was given the modified Shaofu Zhuyu decoction in addition to the treatment of the control group.The therapeutic effects of the two groups were compared,and the Chinese medicine symptom scores,VAS score,5-HT,β-EP,PGE2 levels,and cAMP/PKA signaling pathway were statistically analyzed before and after treatment in both groups.Results:The total effective rate of the treatment group was higher than that of the control group (P<0.05).Before treatment,there was no significant difference in the scores of pain relief,cold pain in the lower abdomen before or during menstruation,cold limbs,refusal to be touched,delayed menstruation,dark menstrual blood with clots,pale complexion,increased white discharge,pain in the breasts or chest and,score of pain relief,VAS score,5-HT,β-EP,PGE2 levels,cAMP,PKA mRNA levels between the two groups (P>0.05);After treatment,the Chinese medicine symptom scores,VAS score,5-HT level,cAMP,PKA mRNA level were lower than those before treatment,while β-EP and PGE2 levels were higher than those before treatment.The scores of pain relief,cold pain in the lower abdomen before or during menstruation,cold limbs,refusal to be touched,delayed menstruation,dark menstrual blood with clots,pale complexion,increased white discharge,pain in the breasts or chest and,VAS score,5-HT level,cAMP,PKA mRNA level of the treatment group were lower than those of the control group,while β-EP and PGE2 levels were higher than those of the control group (P<0.05).Conclusion:For patients with primary dysmenorrhea of the cold-blood-stasis type,the treatment with modified Shaofu Zhuyu decoction combined with ibuprofen can increase the levels of β-EP and PGE2,decrease the level of 5-HT,and inhibit the cAMP/PKA signaling pathway,thereby exerting the effect of relieving pain.

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备注/Memo

备注/Memo:
河北省科学技术研究与发展计划项目(122777644)
更新日期/Last Update: 2026-06-11