[1]赵彩霞,冯子豪,何平.血管内皮生长因子信号通路在儿童紫癜性肾炎中的作用及其中医药干预研究进展[J].陕西中医,2026,(6):860-864.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.026]
　ZHAO Caixia,FENG Zihao,HE Ping.Progress in research on the role of the vascular endothelial growth factor signaling pathway in purpura nephritis and its traditional chinese medicine intervention[J].,2026,(6):860-864.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.026]
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血管内皮生长因子信号通路在儿童紫癜性肾炎中的作用及其中医药干预研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
860-864
栏目:
综 述
出版日期:
2026-06-05

文章信息/Info

Title:
Progress in research on the role of the vascular endothelial growth factor signaling pathway in purpura nephritis and its traditional chinese medicine intervention
作者:
赵彩霞1; 冯子豪2; 何平3
（1.云南中医药大学第一临床医学院，云南 昆明 650500；2.昭通市中医医院，云南 昭通 657000；3.云南中医药大学第一附属医院，云南 昆明 650021）
Author(s):
ZHAO Caixia1; FENG Zihao2; HE Ping3
（1.The First Clinical College of Yunnan University of Traditional Chinese Medicine,Kunming 650500，China；2.Zhaotong Traditional Chinese Medicine Hospital,Zhaotong 657000，China；3.The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine，Kunming 650021，China）
关键词:
紫癜性肾炎; 过敏性紫癜; 血管内皮生长因子; 作用机制; 中医药干预; 综述
Keywords:
Purpura nephritis; Vascular endothelial growth factor; Mechanism of action; Traditional Chinese medicine intervention; Review
分类号:
R 726.9
DOI:
DOI:10.3969/j.issn.1000-7369.2026.06.026
文献标志码:
A
摘要:
紫癜性肾炎(HSPN)是过敏性紫癜(HSP)常见的肾脏并发症，临床发病率较高，其预后与病理损伤程度及治疗时机密切相关，若没有及时干预，将严重影响患儿生活质量及长期预后。目前，该病致病因素复杂，具体发病机制至今仍未完全明晰。近年来，血管内皮生长因子(VEGF)信号通路在HSPN中具有双重调控作用，深入研究该通路有助于阐明疾病机制，也为开发靶向治疗策略指明方向。中医药在HSPN临床实践中展现出其独特疗效，研究表明中医药疗法可通过调控VEGF信号通路，改善组织损伤并促进功能重建，为该病的治疗提供了新思路。本文系统综述VEGF信号通路在HSPN中的作用机制，并整合近年来中医药干预的相关研究进展，以期为优化临床治疗策略提供理论依据。
Abstract:
Henoch-Schonlein purpura nephritis(HSPN) is a prevalent renal complication of Henoch-Schonlein purpura(HSP),with a high clinical incidence.The prognosis of this condition is contingent upon the extent of pathological damage and the timing of treatment.Without prompt intervention,it can significantly compromise the quality of life and long-term prognosis of pediatric patients.At present,the aetiology of the disease is multifactorial,and its specific pathogenesis remains incompletely understood.Recently,the vascular endothelial growth factor (VEGF) signaling pathway has been identified as exerting dual regulatory effects in HSPN.A rigorous investigation of this pathway may elucidate disease mechanisms and guide the development of targeted therapeutic strategies.Traditional Chinese medicine (TCM) has demonstrated particular therapeutic benefits in the clinical management of purpura nephritis.Research indicates that TCM therapies can modulate the VEGF signaling pathway,thereby mitigating tissue damage and promoting functional recovery,offering novel therapeutic perspectives.The present systematic review examines the mechanisms of the VEGF signaling pathway in purpura nephritis and synthesises recent advances in TCM interventions,with a view to providing theoretical foundations for the optimisation of clinical treatment strategies.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82160922）；云南省科技厅科技计划项目（202301AG070116）；何平省级名老中医药专家传承工作室项目
更新日期/Last Update: 2026-06-11