[1]杜 倩,王 浜,吴晶晶.活血消癥方加减联合西药治疗异位妊娠疗效及对患者血清激素水平的影响[J].陕西中医杂志,2021,(4):430-433.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.006]
　DU Qian,WANG Bang,WU Jingjing.Effect of Huoxue Xiaozheng recipe combined with western medicine on ectopic pregnancy and its effect on serum hormone levels[J].,2021,(4):430-433.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.006]
点击复制

活血消癥方加减联合西药治疗异位妊娠疗效及对患者血清激素水平的影响
分享到：

《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年4期
页码:
430-433
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Effect of Huoxue Xiaozheng recipe combined with western medicine on ectopic pregnancy and its effect on serum hormone levels
作者:
杜 倩1; 王 浜1; 吴晶晶2
(1.淮北市人民医院,安徽 淮北 235000; 2.上海中医药大学附属龙华医院,上海 200032)
Author(s):
DU Qian;  WANG Bang;  WU Jingjing
(Huaibei People's Hospital,Huaibei 235000,China)
关键词:
活血消癥方;  异位妊娠;  临床症状;  血清激素;  炎症因子;  不良反应
Keywords:
Huoxue Xiaozheng recipe;  Ectopic pregnancy;  Clinical symptoms;  Serum hormones;  Inflammatory factors;  Adverse reactions
分类号:
R 714.22
DOI:
DOI:10.3969/j.issn.1000-7369.2020.04.006
文献标志码:
A
摘要:
目的:观察活血消癥方加减应用于异位妊娠患者中的临床效果,并观察其对患者血清激素水平及其炎性指标的影响。方法:选取异位妊娠患者(n=60)为研究对象,依据双盲法,将入选患者分成观察组与对照组,其中对照组(n=30)行甲氨蝶呤联合米非司酮治疗,观察组(n=30)在对照组治疗基础上行活血消癥方加减治疗。观察两组患者的疗效、不良反应、治疗前后的血清激素及炎性指标水平。结果:观察组无效1例,总有效率96.67%,对照组无效10例,总有效率66.67%,观察组总有效率高于对照组(P<0.05); 两组包块、腹痛、阴道出血消失时间及血清β-HCG 恢复正常值时间对比,观察组均明显短于对照组(P<0.05); 治疗前,两组患者β-HCG、孕酮、E2水平比较,差异均无统计学意义(P>0.05); 治疗后,两组均有所降低,且观察组明显低于对照组(P<0.05); 且经治疗,观察组CRP及IL-6水平下降低于对照组,差异均具有统计学意义(P<0.05); 观察组及对照组不良反应总发生率为16.67%、53.33%,两组比较差异有统计学意义(P<0.05)。结论:异位妊娠患者采用活血消癥方加减联合西药治疗效果明显,可降低患者血清激素水平,缩短临床症状消失时间,抑制炎症反应,且不良反应少。
Abstract:
Objective:To observe the clinical effect of Huoxue Xiaozheng recipe applied to patients with ectopic pregnancy,and to observe its effect on serum hormone levels and inflammatory indicators.Methods:The ectopic pregnancy patients(n=60)were selected as the research object.According to the double-blind method,the selected patients were divided into an observation group and a control group,of which the control group(n=30)treatment with methotrexate combined with mifepristone,observation group(n=30)added Huoxue Xiaozheng recipe addition and subtraction treatment on the basis of the control group observe the efficacy,adverse reactions,serum hormone levels and inflammatory index levels of the two groups of patients before and after treatment.Results:One case was ineffective in the observation group,with a total effective rate of 96.67%,and 10 cases were ineffective in the control group,with a total effective rate of 66.67%.The total effective rate in the observation group was higher than that in the control group(P<0.05).The disappearance time of vaginal bleeding and the time for serum β-HCG to return to normal value,the observation group was significantly shorter than the control group(P<0.05).Before treatment,the levels of β-HCG,progesterone and E2 in the two groups were not statistically significant(P>0.05).After treatment,both groups decreased,and the observation group was significantly lower than the control group(P<0.05).After treatment,the observation group CRP and IL-6 levels fell lower than the control group,with statistics Significance(P<0.05); The total incidence of adverse reactions in the observation group and the control group was 16.67% and 53.33%,compared between the two groups(P<0.05).Conclusion:The treatment of ectopic pregnancy patients with Huoxue Xiaozheng recipe combined with western medicine has obvious effect,which can reduce the serum hormone levels,shorten the disappearance time of clinical symptoms,inhibit inflammation,and have fewer adverse reactions.

参考文献/References:

[1] 周晴晴,王爱敏,廉 伟,等.口服自拟杀胚消癥汤加灌肠方联合米非司酮、甲氨蝶呤治疗异位妊娠的效果观察[J].中国妇幼保健,2019,34(10):2338-2341.
[2] 石珍珍,李伟莉,胡瑞华,等.异位妊娠药物保守治疗的中西医研究进展[J].中医药临床杂志,2012,24(7):692-694.
[3] 邱嘉菡,袁 烁.化瘀消癥复方联合甲氨蝶呤治疗异位妊娠疗效观察[J].陕西中医,2017,38(9):1203-1204.
[4] 郑春梅,刘晓峰.宫外孕Ⅱ号方加减方治疗异位妊娠的疗效和安全性研究[J].药学服务与研究,2019,19(1):35-37.
[5] 谢 幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:261.
[6] 刘敏如,欧阳惠卿.实用中医妇科学[M].上海:上海科学技术出版社,2010:189-190.
[7] 张玉珍.新编中医妇科学[M].北京:人民军医出版社,2001:433.
[8] 张永会,陈冬琼,彭强丽,等.中西医结合保守治疗异位妊娠的十年回顾性分析研究[J].现代生物医学进展,2018,18(24):4681-4685.
[9] 李 业,李 建,潘 玲,等.异位妊娠中西医病因病机探讨[J].中国中医药现代远程教育,2017,15(22):137-139.
[10] 李亚玲,王宝玲.腹腔镜联合小剂量甲氨蝶呤在160例异位妊娠治疗中的观察[J].陕西医学杂志,2016,45(8):988-990.
[11] 向 睿,杨智玲,叶礼翠,等.输卵管妊娠患者术后重复性异位妊娠情况及其影响因素分析[J].现代生物医学进展,2020,20(8):1536-1539,1544.
[12] 汪清梅,闫军红,王成星.β-HCG指导异位妊娠治疗方式的临床研究[J].河北医药,2019,41(21):3269-3272.
[13] 张崇媛,戴方军,王文容,等.祛瘀活血止痛方辅助治疗异位妊娠疗效观察[J].陕西中医,2017,38(6):744-745.
[14] 侯永丽,厉 健.厉健自拟杀胚消癥方治疗异位妊娠[J].中医药临床杂志,2018,30(4):650-653.
[15] 徐丽霞,顾 晴,吴晓华.异位妊娠从瘀论治再认识[J].浙江中医药大学学报,2016,40(6):475-478.
[16] 陈惠敏.中医外治法对提高不孕症疗效的Meta分析[D].南京:南京中医药大学,2019.
[17] 吴志远.反治法验案两则[J].浙江中医杂志,2018,53(9):17.
[18] 李亚敏,李鸿涛,金哲峰.火针“反治法”治疗热证[J].中国针灸,2019,39(3):296-298.
[19] 曾丽莉,徐春雪,黄丽嫚.血清β-人绒毛膜促性腺激素、降钙素原、C-反应蛋白在预测胎膜早破妊娠患者宫内感染中的应用[J].中国民间疗法,2020,28(12):82-83,88.
[20] 孟幸幸.血清β-HCG及孕酮联合测定诊断早期异常妊娠价值评价[J].云南医药,2020,41(2):180-182.
[21] 王洪玲,张 琰.早期异位妊娠患者β-HCG,E2和P水平变化及预测分析[J].现代预防医学,2019,46(1):64-67.

相似文献/References:

[1]黄 昕,廉 伟△.血府逐瘀汤联合米非司酮治疗异位妊娠疗效研究*[J].陕西中医杂志,2020,(10):1376.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.009]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81704074)
更新日期/Last Update: 2021-04-09