[1]贾 锐,李建武,刘丽霞,等.滋肾清肝化淤方联合阿司匹林治疗子痫前期疗效及安全性研究*[J].陕西中医,2019,(6):749-752.
　JIA Rui,LI Jianwu,LIU Lixia,et al.Study on clinical efficacy and safety Zishen Qinggan Huayu prescription combined with aspirin in patients with Pre-eclampsia patients[J].,2019,(6):749-752.
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滋肾清肝化淤方联合阿司匹林治疗子痫前期疗效及安全性研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年6期
页码:
749-752
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Study on clinical efficacy and safety Zishen Qinggan Huayu prescription combined with aspirin in patients with Pre-eclampsia patients
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.06.019
作者:
贾 锐; 李建武; 刘丽霞; 崔红英
河南省鹤壁市人民医院（鹤壁 458030）
Author(s):
JIA Rui; LI Jianwu; LIU Lixia; et al.
Hebi City People's Hospital in Henan Province（Hebi 458030）
关键词:
滋肾清肝化淤方; 阿司匹林; 子痫; 临床效果; 安全性; 新生儿
Keywords:
Key words Zishen Qinggan Huayu recipe; Aspirin; Eclampsia; Clinical effect; Safety; Newborn
分类号:
R714.24
文献标志码:
A
摘要:
摘 要 目的：探讨滋肾清肝化淤方联合阿司匹林对预防子痫前期效果及安全性的影响。方法：选择80例子痫前期患者，随机数字表法分为两组。对照组予口服阿司匹林75 mg/d直到分娩；观察组在此基础上加用滋肾清肝化淤方。比较两组24ｈ尿蛋白及凝血功能指标、新生儿体重、延长孕周时间以及产后出血量、并发症。结果：两组治疗前后尿蛋白定性及24h尿蛋白定量比较均有统计学差异 ( P ＜0.05)；且治疗后观察组两项指标均显著优于对照组( P ＜0.05)。APTT、纤维蛋白原水平治疗后两组APTT、纤维蛋白原指标有改善，观察组APTT(29.73±3.16)s较对照组(25.02±4.35)s显著增加（ P ＜0.05）。观察组纤维蛋白原(2.74±0.18)g/L较对照组(3.42±0.36)g/L降低（ P ＜0.05）。观察组新生儿体重显著重于对照组（ P ＜0.05）；观察组较对照组显著延长孕周（ P ＜0.05）,两组产后出血量无统计学差异（ P ＞0.05）。两组分娩方式及新生儿结局均无统计学差异（ P ＞0.05）；观察组总并发症发生率20%显著低于对照组35%（ P ＜0.05）。结论：滋肾清肝化淤方联合阿司匹林可有效预防子痫发生，降低子痫前期孕妇的血液高凝状态，延长孕周、改善妊娠结局，且并发症少，安全性较好。
Abstract:
Abstract Objective：To explore the effect of Zishen Qinggan Huayu prescription combined with aspirin on the prevention of preeclampsia effect and safety.Methods：Selected 80 cases of pre-eclampsia patients were admitted.The random number table method was divided into 60 control groups，oral aspirin 75 mg/d until delivery.60 observation group on this basis，add Zishen Qinggan Huayu prescription.The 24h urine protein and coagulation function indexes，neonatal weight，prolonged gestational age，postpartum hemorrhage and complications were compared between the two groups.Results：There were significant differences in urine protein and 24h urine protein between the two groups ( P ＜0.05).After treatment，the two indexes in the observation group were significantly better than the control group ( P ＜0.05).There was no significant difference in fibrinogen levels.After treatment，the APTT and fibrinogen indexes were improved.The APTT (29.73±3.16)s in the observation group was significantly increased compared with the control group (25.02±4.35)s ( P ＜0.05).The proteinogen (2.74±0.18) g/L was significantly lower than the control group (3.42±0.36) g/L ( P ＜0.05).The weight of the newborns in the observation group was significantly higher than that in the control group ( P ＜0.05).Significantly prolonged gestational age ( P ＜0.05).There was no statistically significant difference in postpartum hemorrhage between the two groups ( P ＞0.05).There was no statistically significant difference between the two groups of delivery methods and neonatal outcomes ( P ＞0.05).The incidence of 20% was significantly lower than that of the control group 35%( P ＜0.05).Conclusion：Zishen Qinggan Huayu prescription combined with aspirin can effectively prevent eclampsia，reduce blood hypercoagulability in pregnant women with preeclampsia，prolong gestational age，improve pregnancy outcome，and have fewer complications and better safety.

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备注/Memo

备注/Memo:
*河南省科技攻关计划项目（182102311143）
更新日期/Last Update: 2019-06-20