[1]李树岗.活血化痰通络法辨治老年类风湿关节炎及对患者CRP、ESR的影响研究[J].陕西中医,2018,(10):1429-1431.
 Li Shugang..Study on the effect of activating blood and resolving Phlegm and dredge collaterals on CRP and ESR in elderly-onset rheumatoid arthritis[J].,2018,(10):1429-1431.
点击复制

活血化痰通络法辨治老年类风湿关节炎及对患者CRP、ESR的影响研究
分享到:

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2018年10期
页码:
1429-1431
栏目:
临床研究
出版日期:
2018-12-31

文章信息/Info

Title:
Study on the effect of activating blood and resolving Phlegm and dredge collaterals on CRP and ESR in elderly-onset rheumatoid arthritis
文章编号:
DOI: 10.3969/j.issn.1000-7369.2018.10.036
作者:
李树岗
武汉市第一医院风湿免疫科(武汉 430000)
Author(s):
Li Shugang.
Department of Rheumatology,the First Hospital of Wuhan (Wuhan 430000)
关键词:
关节炎风湿性/中西医结合疗法活血祛瘀剂/治疗疗法祛痰剂/治疗应用老年
Keywords:
Key words Arthritis rheumatoid/integrated Chinese traditional and western medicine therapyAgedBlood-activating stasis-removing agents/therapeutic uses
分类号:
R593.22
文献标志码:
A
摘要:
摘要 目的:通过检测老年类风湿关节炎(EORA)患者在运用活血化痰通络法治疗前后的CRP及ESR指标变化,研究活血化痰通络法辨治老年类风湿性关节炎对CRP及ESR的影响。方法:选取老年类风湿性关节炎患者共317例。随机分为治疗组159例、对照组158例,患者年龄均在60岁以上,对照组仅进行西药治疗,治疗组是在对照组西药治疗的基础上加之活血化痰通络法的中药治疗,对两组患者治疗前后进行指标检测,应用统计学方法对实验结果进行对比分析。结果:活血化痰通络法治疗组有效率为86.79%,对照组有效率为59.49%,两组对比差异有统计学意义(P<0.05);治疗组及对照组治疗前后组内的CRP及ESR的情况对比,两组组内差异均有统计学意义(P均<0.05);活血化痰通络法治疗组的CRP及ESR的改善作用高于对照组,两组对比差异均有统计学意义(P均<0.05)。结论:活血化痰通络法对老年类风湿关节炎患者有较高的治疗作用,能有效改善CRP(C-反应蛋白)及ESR(血沉)等指标,明显改善老年类风湿性关节炎患者的生活状况,可以为以后的临床应用给出真实有效的理论依据的支撑数据,对临床患者的治疗有重要的意义。
Abstract:
Abstract Objective:To investigate the changes of CRP and ESR in elderly patients with rheumatoid arthritis (EORA) before and after treatment with activating blood and resolving Phlegm and dredge collaterals method. CRP and ESR. Methods:A total of 317 elderly patients with rheumatoid arthritis were eligible for inclusion criteria. 317 patients were randomly divided into treatment group (n= 159) and control group (n= 158). The age of the patients was over 60 years old. The control group was treated only by western medicine in the control group. Of traditional Chinese medicine treatment,the two groups of patients before and after treatment of indicators,the application of statistical methods to compare the experimental results. Results:The effective rate was 86.79% in the treatment group and 59.49% in the control group. The difference between the two groups was statistically significant (P<0.05); Treatment group and control group before and after treatment group within the CRP and ESR contrast,inside two way difference had statistical significance (P< 0.05) ;The improvement rate of ESR and ESR was higher than that of the control group (P<0.05). Conclusion:activating blood and resolving Phlegm and dredge collaterals method has a high therapeutic effect on elderly-onset rheumatoid arthritis,and can effectively improve the indexes of CRP and ESR,and improve the patients with rheumatoid arthritis of the living conditions can be given for future clinical application of real and effective data support for clinical treatment of patients has important significance.

参考文献/References:


[1] Zhang J,Chen L,Delzell E,et al. Republished:The association between inflammatory markers,serum lipids and the risk of cardiovascular events in patients with rheumatoid arthritis[J]. Postgraduate Medical Journal,2014,90(10):722-729.
[2]宋彦. 老年类风湿性关节炎患者抑郁状况调查及护理[J]. 贵阳中医学院学报,2014,36(1):132-134.
[3]Pers YM,Schaub R,Constant E,et al. Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis[J]. Joint Bone Spine,2015,82(1):25-30.
[4]王云霞,石怡,陶小芳,等. 强直性脊柱炎患者中医证型与生存质量关系的研究[J]. 辽宁中医杂志,2014,41(4):612-615.
[5]Karpouzas GA,Malpeso J,Choi TY,et al. Prevalence,extent and composition of coronary plaque in patients with rheumatoid arthritis without symptoms or prior diagnosis of coronary artery disease[J]. Annals of the rheumatic diseases,2014,73(10):1797-1804.
[6]温博,唐平,曾升平. 曾升平主任医师治疗类风湿关节炎 60 例临床观察[J]. 云南中医中药杂志,2014,35(5):1-4.
[7]Winthrop K L,Yamanaka H,Valdez H,et al. Herpes zoster and tofacitinib therapy in patients with rheumatoid arthritis[J]. Arthritis&Rheumatology,2014,66(10):2675-2684.
[8]张洁,蔡华珠,张六通. 益气化痰通络方治疗急性脑梗死的临床研究[J]. 中国中医急症,2014,23(7):1222-1223.
[9]毛湄,刘晓玲. 刘晓玲教授治疗系统性红斑狼疮经验介绍[J]. 新中医,2014,46(10):19-21.
[10]赵海方,陈宁,李慧. 宣肺化痰通络法治疗痰瘀阻肺型慢性阻塞性肺疾病稳定期疗效观察[J]. 新中医,2014,46(1):48-51.
[11]Payet S,Soubrier M,Perrodeau E,et al. Efficacy and safety of rituximab in elderly patients with rheumatoid arthritis enrolled in a French Society of Rheumatology registry[J]. Arthritis Care Research,2014,66(9):1289-1295.
[12]黄选华,黄立武,窦维华,等. 益气活血,化痰通络法治疗椎-基底动脉供血不足性眩晕的临床研究[J]. 大众科技,2014,16(5):109-111.
[13]郭芳,于文成,林存智,等. 益气化痰通络法对大鼠肺纤维化的干预作用及其机制的研究[J]. 中国中医急症,2014,23(11):1984-1987.
[14]陈云凤,刘洪,李群英,等. 补肺益肾,化瘀通络法治疗特发性肺间质纤维化的临床研究[J]. 中华中医药杂志,2014,29(9):3030-3032.
[15]周震,王凯,刘爽,等. 化痰通络方对急性脑梗死大鼠 rt-PA 溶栓后不同脑区星形胶质细胞特异性蛋白表达的影响[J]. 中国实验方剂学杂志,2014,20(9):184-189.
[16]Siemons L,ten Klooster PM,Vonkeman HE,et al. How age and sex affect the erythrocyte sedimentation rate and C-reactive protein in early rheumatoid arthritis[J]. BMC musculoskelet al disorders,2014,15(1):368-371.

相似文献/References:

[1]何春辉,马华.复方雪莲拈痛汤治疗活动期类风湿关节炎临床观察[J].陕西中医,2017,(06):748.
[2]田新玮,刘丽丹,游碧荣,等.活血化瘀方联合来氟米特及甲氨蝶呤对类风湿关节炎患者凝血功能的影响[J].陕西中医,2018,(10):1435.
 Tian Xinwei,Liu Lidan,You Birong,et al.Effect of Houxue Huayu decoction combined with leflunomide and methotrexate on coagulation function in patients with rheumatoid arthritis[J].,2018,(10):1435.
[3]唐桂军,郭泉滢△,李培旭.李培旭清热益气通络法治疗痛风性关节炎经验总结*[J].陕西中医,2019,(12):1759.
[4]徐 翀,申利民,苑文杰.当归多糖通过Wnt/β-catenin信号通路抑制骨关节炎软骨细胞氧化应激损伤与炎症反应[J].陕西中医,2022,(6):700.[doi:DOI:10.3969/j.issn.1000-7369.2022.06.005]

更新日期/Last Update: 2019-01-07