[1]马士超,陈秀民,齐志远,等.独活寄生汤对膝关节骨性关节炎行关节置换患者ESR、CRP、MMP9水平的影响[J].陕西中医,2019,(1):79-81.
　MA Shichao,CHEN Xiumin,QI Zhiyuan,et al.Effect of Duhuo Jisheng decoction on ESR, serum CRP and MMP9 levels in patients with knee joint qsteoarthritis[J].,2019,(1):79-81.
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独活寄生汤对膝关节骨性关节炎行关节置换患者ESR、CRP、MMP9水平的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
79-81
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of Duhuo Jisheng decoction on ESR, serum CRP and MMP9 levels in patients with knee joint qsteoarthritis
文章编号:
DOI:10.3969/j.issn.10007369.2019.01.025
作者:
马士超; 陈秀民; 齐志远; 李宇亮
河南省濮阳市中医医院（濮阳 457000）
Author(s):
MA Shichao; CHEN Xiumin; QI Zhiyuan; et al.
Puyang Traditional Chinese Medicine Hospital in Henan Province(Puyang 457000)
关键词:
膝关节骨性关节炎; 独活寄生汤; 全膝关节置换术; 红细胞沉降率; C 反应蛋白;  基质金属蛋白酶
Keywords:
Key words Knee osteoarthritis;  Duhuo Jisheng decoction;  Total knee joint placement;  Erythrocyte sedimentation rate;  Creactive protein;  Matrix metalloproteinase
分类号:
R684.3
文献标志码:
A
摘要:
摘 要 目的：探讨独活寄生汤对膝关节骨性关节炎行关节置换患者血液红细胞沉降率(ESR)、C反应蛋白(CRP)以及基质金属蛋白酶9(MMP9)水平的影响。方法：选取64例膝关节骨性关节炎关节置换手术患者为研究对象，按照随机数表法将患者分为两组，每组32例。两组均接受全膝关节置换治疗，常规护理。观察组在对照组治疗基础上给予独活寄生汤治疗。评价临床疗效和关节功能评分。治疗前后，采集静脉血3 ml，检测ESR、血清CRP、MMP9水平。结果：治疗后观察组总有效率为96.88%，明显高于对照组总有效率78.13%，差异有统计学意义（P<0.05）。治疗前两组患者关节功能评分对比差异不具有统计学意义（P>0.05）；观察组治疗后1个月和3个月关节功能评分均分别低于对照组治疗后1个月和3个月关节功能评分，差异比较具有统计学意义（P<0.05）。两组治疗前ESR、血清CRP、MMP9指标水平对比不具有统计学意义（P>0.05）；两组患者治疗后ESR、血清CRP、MMP9水平均显著下降，观察组指标水平明显低于对照组指标水平，且两组指标水平对比有统计学意义（P<0.05）。 结论：独活寄生汤能够降低膝关节骨性关节炎行关节置换患者的炎症反应水平，且能够改善患者关节功能，提高治疗效果，值得临床应用。 
Abstract:
Abstract Objective: To investigate the clinical effects of Duhuo Jisheng decoction ERS (CRP) and (MMP9) levels in patients with arthritis of knee joint. Methods: 64 patients with knee joint osteoarthritis joint replacement surgery were enrolled in the study. The patients were divided into two groups according to the random number table method, 32 cases in each group. Both groups underwent total knee arthroplasty and routine care. The observation group was given the treatment of Duhuo Jisheng decoction on the basis of the treatment of the control group. Clinical efficacy and joint function scores were evaluated. Before and after treatment, 3 ml of venous blood was collected, and ESR, serum CRP, and MMP9 levels were measured. Results: After treatment, the total effective rate of observation group was 96.88%, which was significantly higher than the total effective rate of the control group of 78.13%, and the data were statistically significant between the two groups(P<0.05). There was no significant difference in the scores of joint functions between the observation group and the control group before treatment (P>0.05). The joint function scores of the observation group at 1 month and 3 months after treatment were lower than those of the control group 1 month and 3 months after treatment, and the joint function scores were statistically significant between the two groups(P<0.05). There was no significant difference in the levels of ESR, serum CRP and MMP9 between the observation group and the control group before treatment (P>0.05). The ESR, serum CRP and MMP9 levels were significantly decreased after treatment, and the observation group was significantly lower than the control group (P<0.05). Conclusion: Duhuo Jisheng decoction can reduce the level of inflammatory reaction in patients with arthrodesis of knee joint osteoarthritis, and can improve the joint function of patients and improve the therapeutic effect. It is worthy of clinical recommendation.

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更新日期/Last Update: 2019-03-13