[1]贾东佩,李春雷△.调神通络针刺法对脑梗死后血管性痴呆患者血清BDNF、VEGF、MMP9的影响*[J].陕西中医,2019,(1):119-121.
　JIA Dongpei,LI Chunlei..Effect of Tiaoshen Tongluo acupuncture in patients with vascular dementia after cerebral infarction and its effects on serum BDNF, VEGF and MMP9[J].,2019,(1):119-121.
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调神通络针刺法对脑梗死后血管性痴呆患者血清BDNF、VEGF、MMP9的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
119-121
栏目:
针灸经络
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of Tiaoshen Tongluo acupuncture in patients with vascular dementia after cerebral infarction and its effects on serum BDNF, VEGF and MMP9
文章编号:
DOI:10.3969/j.issn.10007369.2019.01.038
作者:
贾东佩; 李春雷△
河南省南阳市中心医院神经康复科（南阳 473000）
Author(s):
JIA Dongpei; LI Chunlei.
Department of Neurorehabilitation, Nanyang Central Hospital in Henan Province（Nanyang473000）
关键词:
调神通络针刺法; 脑梗死; 血管性痴呆; 脑源性神经生长因子; 血管内皮生长因子;  基质金属蛋白酶9
Keywords:
Key words Tiaoshen Tongluo acupuncture; Cerebral infarction;  Vascular dementia; Brainderived nerve growth factor; Vascular endothelial growth factor;  Matrix metalloproteinase9〖HK〗〖HT〗〖HJ1〗〖HJ〗
分类号:
R743.3
文献标志码:
A
摘要:
摘 要 目的：研究调神通络针刺法对脑梗死后血管性痴呆患者血清脑源性神经生长因子（BDNF）、血管内皮生长因子（VEGF）、基质金属蛋白酶9（MMP9）的影响。方法：选取83例脑梗死后血管性痴呆患者，根据随机数字法分为观察组（45例）和对照组（38例）。对照组使用常规针刺法，观察组使用调神通络针刺法。比较两组患者生活自理能力，生活质量，精神状况及血清BDNF、VEGF、MMP9水平。结果：治疗后，观察组生活自理能力总有效率显著高于对照组（P<0.05）。观察组生活质量和精神状况评分显著高于对照组（P<0.05）。观察组的血清BDNF、VEGF显著高于对照组（P<0.05），MMP9显著低于对照组（P<0.05）。 结论：调神通络针刺法能有效升高脑梗塞后血管性痴呆患者血清BDNF、VEGF水平，降低 MMP9水平，有助于改善患者生活自理能力、生活质量及精神状况，临床疗效良好。 
Abstract:
Abstract Objective: To study the effects of Tiaoshen Tongluo acupuncture on serum brainderived nerve growth factor (BDNF), vascular endothelial growth factor (VEGF) and matrix metalloproteinase9 (MMP9) in patients with vascular dementia after cerebral infarction influences. Methods: Eightythree patients with vascular dementia after cerebral infarction were enrolled. The patients were divided into observation group (45 cases) and control group (38 cases) according to random number method. The control group was treated with conventional acupuncture, and the observation group was treated with acupuncture. The selfcare ability, quality of life, mental status and serum BDNF, VEGF and MMP9 levels were compared between the two groups. Results: After treatment, the total effective rate of selfcare ability in the observation group was significantly higher than that in the control group (P<0.05). The quality of life and mental status of the observation group were significantly higher than the control group (P<0.05). Serum BDNF and VEGF in the observation group were significantly higher than those in the control group (P<0.05), and MMP9 was significantly lower than the control group (P<0.05). Conclusion: Tiaoshen Tongluo acupuncture can effectively increase the levels of serum BDNF and VEGF and decrease the level of MMP9 in patients with vascular dementia after cerebral infarction, which is helpful to improve the selfcare ability, quality of life and mental state of patients with good clinical efficacy.

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备注/Memo

备注/Memo:
*河南省高等学校青年骨干教师资助计划项目（2011GGJS285）
更新日期/Last Update: 2019-03-13