[1]朱 薇.通脉调脂方治疗冠心病稳定性心绞痛疗效及对患者血流变、VCAM1〖JZ〗及ICAM1影响的研究*[J].陕西中医,2019,(3):290-293.
　ZHU Wei..Effect of Tongmai Tiaozhi recipe on the efficacy, Hemorheology, VCAM1 and ICAM1 〖JZ〗in patients with stable angina pectoris of coronary heart disease[J].,2019,(3):290-293.
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通脉调脂方治疗冠心病稳定性心绞痛疗效及对患者血流变、VCAM1〖JZ〗及ICAM1影响的研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年3
页码:
290-293
栏目:
临床研究
出版日期:
2019-03-05

文章信息/Info

Title:
Effect of Tongmai Tiaozhi recipe on the efficacy, Hemorheology, VCAM1 and ICAM1 〖JZ〗in patients with stable angina pectoris of coronary heart disease
文章编号:
DOI: 10.3969/j.issn.10007369.2019.03.005
作者:
朱 薇
郑州大学附属郑州中心医院中医科（郑州 450007）
Author(s):
ZHU Wei.
Department of Traditional Chinese Medicine,〖JZ〗Zhengzhou Central Hospital Affiliated to Zhengzhou University（Zhengzhou 450007）
关键词:
通脉调脂方; 冠心病; 心绞痛; 稳定型; 血流变; VCAM1; ICAM1
Keywords:
Key words Tongmai Tiaozhi recipe;  Coronary heart disease;  Angina; stable;  Hemorrheology;  VCAM1;  ICAM1
分类号:
R711.74
文献标志码:
A
摘要:
摘 要 目的：探讨自拟通脉调脂方对冠心病稳定性心绞痛患者疗效、血流变、VCAM1及ICAM1的影响。方法：选择我院收治的90例冠心病稳定性心绞痛患者作为研究对象，采用随机数字法分为45例对照组予以常规西药治疗；45例观察组，在对照组基础上予以自拟通脉调脂方口服治疗。系统观察两组患者疗效、血流变及VCAM1、ICAM1指标。结果：两组患者临床疗效比较，观察组总有效率为95.56%，对照组总有效率为75.56%，两组患者临床疗效比较有显著差异（P＜0.05）。两组患者心电图疗效比较，观察组总有效率为86.67%，对照组总有效率为64.44%，两组患者临床疗效比较有统计学差异（P＜0.05）。治疗后观察组运动持续时间、诱发心绞痛发作时间、ST 段下降1 mm时间显著优于对照组（P＜0.05）。治疗后，两组患者血液流变学各指标较治疗前有所降低，观察组血流变指标显著优于对照组(P＜0.05)。治疗后，两组患者VCAM1及ICAM1均较治疗前有所降低，观察组VCAM1及ICAM1水平低于对照组(P＜0.05)。结论：在冠心病稳定性心绞痛的治疗过程中,加用自拟通脉调脂方能有效减少心绞痛发作次数，减轻胸痛症状,提高临床疗效，其机制可能与自拟通脉调脂方改善冠心病稳定性心绞痛患者血流变指标及调节VCAM1、ICAM1表达有关。
Abstract:
Abstract Objective：To explore the effect of Tongmai Tiaozhi recipe on the curative effect, blood rheology, VCAM1 and ICAM1 in patients with stable angina pectoris. Methods：90 patients with stable angina pectoris in our hospital were selected as the research object, and 45 patients in the control group were treated with routine western medicine and 45 patients in the observation group were treated with Tongmai Tiaozhi recipe. The efficacy, blood rheology and VCAM1 and ICAM1 indexes of the two groups were observed. Results： The total effective rate was 95.56% in the observation group and 75.56% in the control group. There was significant difference in the two groups (P<0.05). The total effective rate was 86.67% in the observation group and 64.44% in the control group. Two value of bed effect was significantly difference (P<0.05).After treatment, VCAM1 and ICAM1 in both groups were lower than those before treatment, and the levels of VCAM1 and ICAM1 in the observation group were significantly lower than those in the control group (P<0.05). Conclusion：In the treatment of stable angina pectoris of coronary heart disease, Tongmai Tiaozhi recipe can effectively reduce the frequency of attack of angina pectoris, relieve the symptoms of chest pain and improve the clinical efficacy. The mechanism may be related to the improvement of blood rheological indexes and the regulation of VCAM1 and ICAM1 expression in stable angina pectoris of coronary heart disease by Tongmai Tiaozhi recipe. It is worthy of clinical promotion and application.

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备注/Memo

备注/Memo:
*河南省科技计划项目（201406131025）
更新日期/Last Update: 2019-03-13