[1]马志宾,陈 燕,苏 永.促排卵汤对多囊卵巢综合征患者血清淀粉样蛋白P、脂肪因子 与白介素-18的影响研究*[J].陕西中医,2019,(5):651-654.
　MA Zhibin,HU Xiaohua,SU Yong ..Effect of Cupailuan decoction combined with life style on serum SAP, Apelin and IL-18 in women with polycystic ovary syndrome[J].,2019,(5):651-654.
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促排卵汤对多囊卵巢综合征患者血清淀粉样蛋白P、脂肪因子 与白介素-18的影响研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年5期
页码:
651-654
栏目:
临床研究
出版日期:
2019-05-05

文章信息/Info

Title:
Effect of Cupailuan decoction combined with life style on serum SAP, Apelin and IL-18 in women with polycystic ovary syndrome
文章编号:
DOI:〖HT5K〗10.3969/j.issn.1000-7369.2019.05.031
作者:
马志宾1 ; 陈 燕2 ; 苏 永
1．河南省南阳市第一人民医院生殖医学科（南阳 473000）；2．河南省南阳市中心医院（郑州 473000）； 3．河南省人民医院妇产科（郑州 450000）
Author(s):
MA Zhibin; HU Xiaohua;  SU Yong .
Reproductive Medicine of the First People's Hospital of Nanyang City( Nanyang 473000)
关键词:
多囊卵巢综合征; 促排卵汤; 氯米芬; 血清淀粉样蛋白P; 脂肪因子; 白细胞介素-18
Keywords:
Polycystic ovary syndrome; Cupailuan decoction;  Chlorine meters finn;  SAP; Apelin ; IL-18
分类号:
R711.75
文献标志码:
A
摘要:
摘 要 目的：探究促排卵汤对多囊卵巢综合征患者血清淀粉样蛋白P（SAP）、脂肪因子（Apelin）与白细胞介素-18（IL-18）的影响。方法：选取98例多囊卵巢综合征患者为研究对象，将患者采用随机数字表法分为对照组和观察组各49例。对照组采用氯米芬治疗，观察组患者在此基础上给予促排卵汤治疗。比较两组患者促性腺激素、IL-18、SAP、AST、尿素氮、血肌酐、临床疗效。结果：治疗前观察组和对照组患者的血清IL-18、LH、FSH、E2 、T水平差异无统计学意义（P＞0.05）；治疗后两组患者的血清IL-18、LH、E2 水平较治疗前均降低，FSH水平升高，且观察组患者变化程度较对照组患者显著（P＜0.05）。治疗前观察组和对照组患者的血清SAP、AST、尿素氮、血肌酐、Apelin水平差异无统计学意义（P＞0.05）；治疗后观察组和对照组患者的血清AST、尿素氮、血肌酐水平差异无统计学意义（P＞0.05）；治疗后血清SAP、Apelin较治疗前均降低，且观察组患者变化程度较对照组患者显著（P＜0.05）。治疗后观察组和对照组患者的临床总有效率分别为87.74％和71.42％，差异具有统计学意义（P＜0.05）。结论：多囊卵巢综合征患者经促排卵汤治疗较单纯使用氯米芬治疗能显著改善促性腺激素的分泌，降低血清SAP、Apelin与IL-18水平，改善临床疗效。
Abstract:
Abstract Objective: To explore the effect of Cupailuan decoction on serum amyloid P (SAP), Apelin and interleukin-18 (IL-18) in women with polycystic ovary syndrome. Methods: A total of 98 patients with polycystic ovary syndrome (pcos) were selected as study objects. The control group was treated with clomiphene, and the observation group was treated with Cupailuan decoction. The clinical efficacy of gonadotropin, il-18, SAP, AST, urea nitrogen, blood creatinine and serum were compared between the two groups. Results: There was no statistically significant difference in serum il-18, LH, FSH, E2 and T levels between the observation group and the control group before treatment (P> 0.05). After treatment, serum il-18, LH and E2 levels of the two groups were decreased and FSH levels were increased compared with those of the control group (P<0.05). There was no statistically significant difference in serum SAP, AST, urea nitrogen, creatinine and Apelin levels between the observation group and the control group before treatment (P>0.05). There was no significant difference in serum AST, urea nitrogen and serum creatinine levels between the observation group and the control group after treatment (P>0.05). After treatment, serum SAP and Apelin decreased compared with before treatment, and the change degree of the observation group was greater than that of the control group (P<0.05). After treatment, the total clinical efficiency of the observation group and the control group was 87.74% and 71.42%, respectively, with statistically significant differences (P<0.05). Conclusion:Compared with clomiphene alone, the treatment of Cupailuan decoction can significantly improve the secretion of gonadotropin, reduce the level of serum SAP, Apelin and il-18, and improve the clinical efficacy, which can be further promoted and used. 〖LM〗

参考文献/References:

[1] Haoula,Z,Shaw,B,Daykin,C. et al.Validation of proteomic biomarkers previously found to be differentially Expressed in women with polycystic ovary syndrome: a cross-sectional study [J].Gynecological Endocrinology: the Official Journal of the International Society of Gynecological Endocrinology,2014,30(3):213-216.
[2] Shi,Y,Cui,Y,Sun,X. et al.Hypertension in women with polycystic ovary syndrome: Prevalence and associated cardiovascular risk factors [J].European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal,2014,173(1):66-70.
[3] 王 权,秦 芬.多囊卵巢综合征患者血清SAP表达的临床意义 [J].浙江临床医学,2015,17(11):1952-1953.
[4] 蒋婷婷,潘 景,苏 莹,等.脂肪因子Vaspin、Apelin及瘦素与多囊卵巢综合征的相关性 [J].昆明医科大学学报,2016,37(10):41-46.
[5] 陈 静,李 萍,沙艳伟,等.白细胞介素-18与多囊卵巢综合征患者自然流产的关系研究 [J].中国妇幼保健,2015,30(35):6285-6286.
[6] 杨焕芳.中西医结合治疗多囊卵巢综合征的应用与疗效评估 [J].实用中西医结合临床,2018,18(5):85-86.
[7] Shen W,Li T,Hu Y. et al.Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression [J].Archives of Gynecology and Obstetrics,2014,289(1):107-118.
[8] Sprung VS,Jones H,Pugh C,et al.Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition [J].Clinical Science,2014,126(1/2):67-74.
[9] 王国萍,吴瑞芳,汤慧茹,等.氯米芬和来曲唑在多囊卵巢综合征不孕患者微刺激促排卵中的应用比较 [J].实用妇产科杂志,2014,30(10):746-749.
[10] 陈 欣,宋 岩,邓永志,等.慢性炎症因子参与多囊卵巢综合征发病的初步探讨 [J].中国妇幼保健,2016,31(22):4635-4636.
[11] 陈沛林,陈光元,谢家滨,等.血清炎症因子在多囊卵巢综合征患者中的表达及其临床意义 [J].海南医学,2016,27(12):1945-1947.
[12] 郭银华,谈 勇,邹奕洁,等.补肾促排卵汤对PCOS模型大鼠颗粒细胞芳香化酶的影响 [J].南京中医药大学学报,2016,32(1):38-40.
[13] 邱建萍.肾虚血瘀型青春期多囊卵巢综合征中药干预临床研究[D].新疆医科大学,2017.
[14] 黄 豆,丁秋雪,李海燕,等.多囊卵巢综合征患者血清中C-反应蛋白、白介素-18的表达水平及临床意义 [J].中国保健营养,2016,26(14):35-36.
[15] 王 钰,李小燕,宋民喜.不同表型多囊卵巢综合征患者甲状腺功能改变及临床意义 [J].陕西医学杂志,2016,45(10):1303-1305.
[16] 黄红艺,莫 云,何 冰,等.多囊卵巢综合征不孕患者血清Apelin水平与胰岛素抵抗的关系 [J].实用医学杂志,2014,11(4):551-553.
[17] 谢 伟,牛建昭,薛晓鸥.牛建昭教授治疗多囊卵巢综合征经验拾要 [J].陕西中医,2017,38(12):1763-1764.

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备注/Memo

备注/Memo:
*河南省卫生厅基础研究计划项目（132300410040）
更新日期/Last Update: 2019-05-07