[1]吕永飞,陈爱莲.益心康泰胶囊治疗冠心病经皮冠状动脉介入术术后疗效及对患者血流变、血管内皮功能的影响*[J].陕西中医,2019,(6):714-717.
　LV Yongfei,CHEN Ailian..Effect of Yixin Kangtai capsule on the curative effect hemorheology and vascular endothelial function after coronary artery disease PCI[J].,2019,(6):714-717.
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益心康泰胶囊治疗冠心病经皮冠状动脉介入术术后疗效及对患者血流变、血管内皮功能的影响*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年6期
页码:
714-717
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Effect of Yixin Kangtai capsule on the curative effect hemorheology and vascular endothelial function after coronary artery disease PCI
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.06.009
作者:
吕永飞; 陈爱莲
河南省濮阳市中医院心内科（濮阳 457000）
Author(s):
LV Yongfei; CHEN Ailian.
Department of Cardiology,Puyang City Hospital of Traditional Chinese Medicine（Puyang 457000）
关键词:
冠心病; 益心康泰胶囊;  经皮冠状动脉介入术; 临床疗效; 血流变; 血管内皮功能
Keywords:
Key words Coronary heart disease; Yixin Kangtai capsule; Percutaneous coronary intervention; Curative effect; Hmorheology; Vcular endothelial function
分类号:
R541.4
文献标志码:
A
摘要:
摘 要 目的：探讨益心康泰胶囊治疗冠心病经皮冠状动脉介入术（PCI）术后疗效及对患者血流变及血管内皮功能的影响。方法：选择120例冠心病PCI患者作为研究对象，采用随机数字法分为60例对照组，予以常规西药治疗；60例观察组，在对照组基础上予以益心康泰胶囊口服治疗。系统观察两组患者疗效、血流变及血管内皮功能指标。结果：治疗后，两组患者中医症候总积分均较治疗前显著改善（ P ＜0.05），组间比较，观察组中医症候积分显著优于对照组（ P ＜0.05）。观察组总有效率为91.67%，显著高于对照组总有效率73.33%（ P ＜0.05）。治疗后，两组患者血液流变学各指标较治疗前有所降低，观察组血流变指标显著优于对照组( P ＜0.05)。经治疗，两组患者血清NO及ET-1均较治疗前显著改善，组间比较，观察组血清NO及ET-1均显著优于对照组（ P ＜0.05）。结论：益心康泰胶囊能够显著改善冠心病PCI术后患者自觉症状，提高临床疗效，其机制可能与益心康泰胶囊能改善冠心病PCI术后患者血流变指标及血管内皮功能有关。
Abstract:
Abstract Objective：To investigate the effect of Yixin Kangtai capsule on hemorheology and vascular endothelial function after PCI for coronary heart disease .Methods：120 patients with PCI of coronary heart disease admitted were selected as the research objects，and randomly divided into 60 cases of control groups treated with conventional western medicine. 60 cases of observation group were treated with Yixin Kangtai capsule on the basis of control group.Systematic observation indexes：curative effect，blood rheology and vascular endothelial function of the two groups.Results：After treatment，the total scores of TCM symptoms in the two groups were significantly improved compared with those before treatment ( P ＜0.05)，and the scores of TCM symptoms in the observation group were significantly better than those in the control group ( P ＜0.05).The total effective rate in the observation group was 91.67%，which was significantly higher than that in the control group 73.33%( P ＜0.05).After treatment，the indexes of hemorheology in the two groups were decreased compared with those before treatment. The indexes of blood rheology in the observation group were significantly better than those in the control group ( P ＜0.05).After treatment，the levels of serum nitric oxide (NO) and ET-1 in the two groups were significantly improved compared with those before treatment.The levels of serum NO and ET-1 in the observation group were significantly better than those in the control group ( P ＜0.05).Conclusion：Yixin Kangtai capsule can significantly improve the conscious symptoms and clinical efficacy of patients with coronary heart disease after PCI.Its mechanism may be related to Yixin Kangtai capsule can improve blood rheological parameters and vascular endothelial function after PCI，which is worthy of clinical promotion.

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备注/Memo

备注/Memo:
*河南省濮阳市科学技术局科研项目（1421310208）
更新日期/Last Update: 2019-06-20