[1]闫 风,连永红,姚成栋,等.大黄红藤消炎合剂治疗急性胰腺炎疗效及对患者淀粉酶、炎症因子影响*[J].陕西中医,2019,(6):729-732.
　YAN Feng,LIAN Yonghong,YAO Chengdong,et al.Effect of Dahuang Hongteng Xiaoyan mixture on acute pancreatitis amylase and inflammatory factors[J].,2019,(6):729-732.
点击复制

大黄红藤消炎合剂治疗急性胰腺炎疗效及对患者淀粉酶、炎症因子影响*
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年6期
页码:
729-732
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Effect of Dahuang Hongteng Xiaoyan mixture on acute pancreatitis amylase and inflammatory factors
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.06.013
作者:
闫 风1; 连永红1; 姚成栋1; 于刘芳1; 谢 清
1.河南省开封市中医院（开封 475000）；2.河南大学第一附属东京医院（开封475001）
Author(s):
YAN Feng; LIAN Yonghong; YAO Chengdong; et al.
Kaifeng City Hospital of Traditional Chinese Medicine,in Henan Provence（Kaifeng 475000）
关键词:
大黄红藤消炎合剂; 急性胰腺炎; 临床疗效; 淀粉酶; 炎症因子; APACHEⅡ评分; Ｒanson评分
Keywords:
Key words Dahuang Hongteng Xiaoyan mixture; Acute pancreatitis; Clinical efficacy; Amylase; Inflammatory factor; APACHEⅡscore; Ranson score
分类号:
R657.5
文献标志码:
A
摘要:
摘 要 目的：探讨大黄红藤消炎合剂治疗急性胰腺炎疗效及对患者淀粉酶及炎症因子的影响。方法：对60例重症急性胰腺炎患者，按照随机数字表法分为两组，每组30例。对照组予常规内科治疗，观察组在对照组基础上加用大黄红藤消炎合剂联合治疗。系统观察两组临床疗效、淀粉酶及炎症因子指标。结果：观察组总有效率90%，显著高于对照组76.67%（ P ＜0.05）。两组APACHEⅡ、Ranson、MCTSI、IAP评分均较治疗前有显著改善（ P ＜0.05）。两组之间比较，观察组较对照组显著改善（ P ＜0.05）；观察组缓解时间各指标均显著少于对照组（ P ＜0.05）。治疗后两组淀粉酶及白细胞计数显著降低，且观察组显著低于对照组（ P ＜0.05）。治疗前两组患者IL-1β、Endotoxin、PCT、sICAM-1水平比较均无统计学差异（ P ＞0.05）。治疗后，两组均较治疗前有显著改善（ P ＜0.05），两组之间比较，观察组较对照组显著改善（ P ＜0.05）。结论：大黄红藤消炎合剂佐治急性胰腺炎疗效显著，改善APACHEⅡ、Ｒanson评分及临床症状，尽快降低血尿淀粉酶及炎症因子含量，促进其早日康复。
Abstract:
Abstract Objective：To explore the effect of Dahuang Hongteng Xiaoyan mixture on the treatment of acute pancreatitis，amylase and inflammatory factors.Medthods：60 patients with severe acute pancreatitis admitted were divided into two groups according to the random number table method，30 patients in each group.The control group received routine medical treatment.The observation group was supplemented with Dahuang Hongteng Xiaoyan mixture on the basis of the control group.Auxiliary treatment.Systematic observation：clinical efficacy，amylase and inflammatory factors in both groups.Results：Total effective rate of the observation group was 90% significantly higher than that of the control group 76.67% ( P ＜0.05).The scores of APACHEII，Ranson，MCTSI and IAP in the two groups were significantly improved compared with those before treatment （ P ＜0.05）.The observation group was significantly improved compared with the control group（ P ＜0.05）.The observation time of the observation group was significantly lower than that of the control group( P ＜0.05).After treatment，the amylase and white blood cell counts of the two groups were significantly lower，and the observation group was significantly lower than the control group（ P ＜0.05）.Before treatment，there was no significant difference in IL-1β，Endotoxin，PCT and sICAM-1 between the two groups （ P ＞0.05）.After treatment，the two groups were significantly improved compared with before treatment （ P ＜0.05）.Compared with the control group，the observation group showed significant improvement （ P ＜0.05）.Conclusion：Dahuang Hongteng Xiaoyan mixture is effective in treating acute pancreatitis，improving APACHE II，Ranson score and clinical symptoms，reducing blood urease amylase and inflammatory factors as soon as possible，and promoting its early recovery.

参考文献/References:

[1] 于春林，张国志.一氧化氮对急性胰腺炎影响的研究进展[J].实用药物与临床,2016，19(7):909-912.
[2]刘 妍.大柴胡汤对急性胰腺炎患者凝血功能和炎症因子的影响[J].陕西中医,2016，37(7):854-855.
[3] 邱嘉华,黄锦文,张春忙.奥曲肽联合柴胡承气汤对急性胰腺炎血清炎症介质的影响[J].陕西中医,2016,37(8):942-943.
[4] 钟利国,高俊美,冯文忠.中药内服与高位保留灌肠治疗急性胰腺炎40例疗效观察[J].湖北中医药大学学报，2017，19(2):66-68.
[5] 王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013年,上海)[J].中华消化杂志，2013，29(7):656-660.
[6] 张声生,李乾构,李慧臻,等.急性胰腺炎中医诊疗专家共识意见[J].中华中医药杂志，2013，10(6):1826-1831.
[7] 刘敏姬,陈维顺,金少纯,等.高脂血症性急性胰腺炎的临床特点分析[J].中国现代医药杂志，2016，15(1):55-57.
[8] 洪 琛,向正国,陈旭峰,等.乌司他丁联合奥曲肽治疗急性胰腺炎的疗效及对细胞因子影响的研究[J].山西医药杂志,2017,46(16):2011-2013.
[9] 冯小萌,王 原.急性胰腺炎发病机制及治疗研究进展[J].世界最新医学信息文摘，2017，40(2):26-30.〖ZK)〗
[10] 李敏利,张晓华,金鑫鑫. 前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察[J].解放军医学杂志,2017,42(2):140-143.
[11] 林 楠,滕 旭,许玲芬,等.IL-1β对肠上皮细胞屏障通透性的影响[J].国际儿科学杂志,2016,43(5):409-412.
[12] 吕有凯,林明强,王日兴,等.急性感染性休克患者血清PCT和急性时相蛋白动态表达及其临床意义[J].海南医学,2016,27(11):1744-1746.
[13] 杨记康,邢志芳.加减清胰汤经空肠管鼻饲治疗重症急性胰腺炎临床观察[J].陕西中医，2017,38(9):1189-1191.
[14] 杨卫生,吴 峰,周 岑,等.大黄芒硝汤联合参麦注射液辅助治疗重症急性胰腺炎疗效观察[J].中国中西医结合消化杂志,2017，12(1):59-61.
[15] 杜进龙. 中医综合方案联合西医常规治疗急性胰腺炎的临床疗效观察[J].中国中医基础医学杂志，2018，10(1):87-89.
[16] 孟 海,程 辉.参麦注射液治疗急性胰腺炎患者的临床研究[J].世界中西医结合杂志，2017,7(4):527-529.
[17] 李 敏,高 凯,王华林,等.柴胡皂苷d-黄芩苷配伍对CCl_4诱导大鼠HSC的TLR4-NF-κB通路作用研究[J].陕西中医,2018，39(1):110-114.

相似文献/References:

[1]程相超.重症急性胰腺炎应用凉膈散联合乳果糖治疗对患者炎症反应的影响[J].陕西中医,2019,(7):879.
　CHENG Xiangchao..Influence for inflammatory reaction and microcirculation of severe acute pancreatitis in icu by Lianggesan and lactulose[J].,2019,(6):879.
[2]代晓玉,吴秋葶,姚佳琦,等.升降散治疗急性胰腺炎并发多器官功能障碍机制研究[J].陕西中医,2022,(5):550.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.002]
　DAI Xiaoyu,WU Qiuting,YAO Jiaqi,et al.The potential mechanisms of Shengjiang powder protect against multiple organ dysfunction in acute pancreatitis mice[J].,2022,(6):550.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.002]
[3]刘鸿雁,王 敏,古玉兰.柴芩承气汤保留灌肠治疗腑实热结型急性胰腺炎疗效及对患者中医症候积分、血清淀粉酶的影响[J].陕西中医,2022,(11):1551.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.014]
　LIU Hongyan,WANG Min,GU Yulan.Efficacy of Chaiqin Chengqi decoction retention enema in the treatment of acute pancreatitis of heat stagnation and Fu-organ excess type and its influence on scores of TCM syndromes and serum amylase[J].,2022,(6):1551.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.014]
[4]刘锟荣,卢 洁,秦百君,等.清解化攻汤对急性胰腺炎大鼠肠黏膜屏障和血清炎症因子的影响[J].陕西中医,2023,(2):149.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.003]
　LIU Kunrong,LU Jie,QIN Baijun,et al.Effects of Qingjie Huagong decoction on intestinal mucosal barrier and serum inflammatory factors in rats with acute pancreatitis[J].,2023,(6):149.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.003]
[5]尹 诗,谢安卫,肖敬鄂,等.二草清胰汤内服及保留灌肠联合乌司他丁治疗急性胰腺炎临床研究[J].陕西中医,2023,(2):183.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.010]
　YIN Shi,XIE Anwei,XIAO Jing'e,et al.Clinical study of oral administration and retention enema with Ercao Qingyi decoction combined with ulinastatin in the treatment of acute pancreatitis[J].,2023,(6):183.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.010]
[6]唐 莉,李丹丹.大承气汤联合清热通腑灌肠方治疗急性胰腺炎疗效研究[J].陕西中医,2023,(3):333.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.014]
　TANG Li,LI Dandan.Efficacy study on Dachengqi decoction combined with Qingre Tongfu Guanchang decoction in treating acute pancreatitis[J].,2023,(6):333.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.014]
[7]王 敏,罗小华,卢娟娟.通腑解毒方联合六合丹辅助西医治疗急性胰腺炎临床研究[J].陕西中医,2023,(4):471.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.014]
　WANG Min,LUO Xiaohua,LU Juanjuan.Clinical study of Tongfu Jiedu recipe combined with Liuhe Dan assisted western medicine in treating acute pancreatitis[J].,2023,(6):471.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.014]
[8]龙丹丹,姜 爽.清胆解毒汤合四逆散治疗急性胰腺炎肝胆湿热证临床研究[J].陕西中医,2024,(6):767.[doi:DOI:10.3969/j.issn.1000-7369.2024.06.009]
　LONG Dandan,JIANG Shuang.Qingdan Jiedu decoction combined with Sini powder in the treatment of acute pancreatitis with liver and gallbladder damp-heat syndrome[J].,2024,(6):767.[doi:DOI:10.3969/j.issn.1000-7369.2024.06.009]

备注/Memo

备注/Memo:
*河南省卫生和计划生育委员会科研项目（H2017555）
更新日期/Last Update: 2019-06-20