[1]屈 凯,王悦彤,王漱非,等.基于文献研究探讨益肾散结法防治肾小球硬化的理论内涵*[J].陕西中医,2019,(7):919-923.
　QU Kai,WANG Yuetong,WANG Shufei,et al.Based on literature research to explore the theoretical connotation of Kidney-reinforcing and Mass-disintegrating for prevention and treatment of glomerulosclerosis[J].,2019,(7):919-923.
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基于文献研究探讨益肾散结法防治肾小球硬化的理论内涵*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年7期
页码:
919-923
栏目:
学术探讨
出版日期:
2019-07-05

文章信息/Info

Title:
Based on literature research to explore the theoretical connotation of Kidney-reinforcing and Mass-disintegrating for prevention and treatment of glomerulosclerosis
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.07.030
作者:
屈 凯1; 王悦彤2; 王漱非1; 李现成1; 张 楠1; 赵亚峰1△; 王 宇1; 张 鹏1; 程小红
1.陕西省中医医院（西安 710003）；2.陕西中医药大学（咸阳712046）
Author(s):
QU Kai; WANG Yuetong; WANG Shufei; et al.
Shaanxi Hospital of Chinese Medicine （Xi’an 710003）
关键词:
益肾散结; 肾小球硬化; 文献研究; 防治; 慢性肾脏病; 理论内涵
Keywords:
Key words Kidney-reinforcing and Mass-disintegrating; Glomerulosclerosis; Literature research;  Prevention and treatment; Chronic kidney disease; Theoretical connotation
分类号:
R692.6
文献标志码:
A
摘要:
摘 要 目的：探讨“益肾散结”学术观点防治肾小球硬化的理论内涵。方法：采用EpiData3.0建立数据库，运用SPSS16.0软件描述性统计分析,梳理肾小球硬化的证候分布规律及中药性味归经等特点。结果：基于文献研究结果得出，肾小球硬化中医病位类证候要素由高至低依次为肾（24，50.0%）、脾（17，35.4%）、肝（3，6.3%）、肺（2，4.2%）、心（2，4.2%）、络（2，4.2%）；病性类证候要素由高至低依次为气虚（28，32.9%）、血瘀（25，29.4%）、湿浊（16，18.8%）、阴虚（13，15.3%）、湿热（9，10.6%）、浊毒（8，9.4%）、痰（3，3.5%）、风（3，3.5%）、水（1，1.2%）。从归经角度分析，181味药物中归肾经的药物有60味，归肝经的药物有96味，归脾经的药物有63味，归肺经的药物有62味，归心经的药物有40味，从性味角度分析，归酸味的药物有18味，归苦味的药物有81味，归甘味的药物有91味，归辛味的药物有53味，归咸味的药物有17味。结论：从肾小球硬化的中医理论、临床应用文献角度分析，肾虚日久致瘀血阻肾络的功能失调是肾小球硬化的主要中医病因病机，进一步诠释益肾散结法防治肾小球硬化具有科学内涵。
Abstract:
Abstract Objective:To explore the theoretical connotation of the academic viewpoint of Kidney-reinforcing and Mass-disintegrating in preventing and treating glomerulosclerosis.Methods:EpiData 3.0 was used to establish the database,SPSS16.0 software was used to describe the statistical analysis,combing the distribution of glomerulosclerosis symptoms and the meridian attribution characteristics of traditional Chinese medicine.Results:Based on the results of literature research,the TCM location syndrome elements of glomerulosclerosis from high to low were kidney(24,50.0%),spleen(17,35.4%),liver(3,6.3%),lung(2,4.2%),heart(2,4.2%) and collaterals(2,4.2%);The pathogenic syndrome elements were deficiency of vital energy(28,32.9%),blood stasis(25,29.4%),turbid damp(16,18.8%),Yin deficiency(13,15.3%),dampness and heat(9,10.6%),turbidity and toxin(8,9.4%),phlegm(3,3.5%),wind(3,3.5%),and water(1,1.2%) from high to low.From the perspective of meridians,among 181 drugs,there were 60 drugs for kidney channel,96 medicines for the liver meridian,63 medicines for the spleen meridian,62 medicines for the lung meridian,40 medicines for the heart meridian,From the point of view of property and flavor,there were 18 sour drugs,81 bitter ones,91 sweet ones,53 spicy ones,17 salty ones,47 mild ones and 9 astringent ones.Conclusion:Based on literature research and practice,it is confirmed that the academic viewpoint of Kidney-reinforcing and Mass-disintegrating has scientific connotation in preventing and treating glomerulosclerosis.

参考文献/References:

[1] 王海燕.肾脏病学[M].北京：人民卫生出版社,2008:783-785. [2] 屈 凯,李现成,张 楠,等.肾复康Ⅱ号胶囊中两种主要药物的有效成分对大鼠肾小球系膜细胞氧化应激反应相关因子的影响[J].中国中西医结合肾病杂志,2016,17(2)：400-402. [3] 王漱非.益肾散结法对阿霉素肾病模型大鼠肾组织podocin蛋白及尿中足细胞数量的影响[D].陕西中医学院,2014. [4] 王漱非,程小红.肾复康Ⅱ号胶囊对阿霉素肾病模型大鼠尿中足细胞计数及骨架蛋白podocin影响的实验研究[J].陕西中医,2014,35(5):609-611. [5] 李德新.中医基础理论[M].北京:人民卫生出版社,2010:76-77,269. [6] 屈 凯.基于证候要素及病证结合模式建立慢性肾衰竭诊断标准的思路[J].中华中医药杂志,2014,29(11):3364-3365. [7] 王天芳.病证结合诊断标准的建立[J].中国中西医结合杂志,2011,31(8):1025-1026. [8] 王小雪,卢 杉,郑思悦.归经中药化学成分、药理作用及临床应用的实证分析[J].中华中医药杂志,2018,33(11):5193-5194. [9] 史 健,刘建红,程小红,等.肾复康Ⅱ号对大鼠肾间质纤维化及转化生长因子-β1的影响[J].中药药理与临床,2012,28(3):99-100. [10] 史 健,杨洪涛,胡 锐,等.肾复康Ⅱ号抗肾间质纤维化及对人肾上皮小管细胞转分化的作用[J].陕西中医,2014,35(1):103-105.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目（81603454） 陕西省科技厅社会发展领域项目（2017SF-295
更新日期/Last Update: 2019-07-12