参考文献/References:
[1] 雷蕊娥,康 健.四逆汤治疗冠心病心绞痛64例疗效分析[J].中国实用医药,2012,7(18):193.
[2] 喻少峰.四逆汤治疗心力衰竭临床疗效及其对血浆BNP水平的影响[J].河南中医,2014,34(5):801.
[3] 赵小祺,王春光,焦 宏,等.四逆汤对急性心肌梗死溶栓后再灌注损伤的保护作用[J].中国老年学杂志,2014,34(3):590.
[4] Luo J,Zhang Y,Hu X,et al.The effects of modified sini decoction on liver injury and regeneration in acute liver failure induced by D-galactosamine in rats[J].J Ethnopharmacol.2015,23(161):53-59.
[5] 李 洁,邱建利,许 华.加味茵陈四逆汤对肝纤维化小鼠Smad7及Ⅰ、Ⅲ型胶原蛋白表达的影响[J].中药材，2016,39(6):1384-1388.
[6] 陈嘉璐,李湧健,张晓迪,等.四逆汤上调p53蛋白表达诱导肝癌细胞凋亡研究[J].中华中医药杂志，2013,28(2):548-551.
[7] 陈嘉璐,李湧健,张 蕾,等.四逆汤对肝癌细胞PCNA和cyclinD1影响的实验研究[J].时珍国医国药,2013,24(5):1162-1165.
[8] 孙志祥,郭琳琳,田 野.四逆汤对脓毒性休克患者目标导向性治疗和血清炎性因子的影响[J].世界中医药,2018,13(4):842-845.
[9] 陈兰英,吴 刚,陈 卓,等.四逆汤抗失血性休克大鼠肠黏膜损伤及菌群移位药效研究[J].中国实验方剂学杂志,2011,17(23):121-124.
[10] Tan G, Liao W,Dong X,et al.Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats[J].PLoS One,2012,7(4):e34157.
[11] Peter K,Schinnerl J,Felsinger S,et al. A novel concept for detoxification:complexation between aconitine and liquiritin in a Chinese herbal formula(Sini Tang) [J].Journal of Ethnopharmacology，2013，149,562-569.
[12] Cai Y,Gao Y,Tan G，et al.Myocardial lipidomics profiling delineate the toxicity of traditional Chinese medicine Aconiti Lateralis radix praeparata[J].Journal of Ethnopharmacology， 2013，147,349-356.
[13] Zhou J,Ma X,Shi M,et al.Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats[J].Phytomedicine，2017,15(31):18-31.
[14] Liu YT,Jia HM,Chang X,et al.The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics[J].Molecular bioSystems,2013,9:2823-2834.
[15] Drews J.Drug discovery:a historical perspective[J].Science,2000,287(5460):1960-1964.
[16] Wang L,Zhou GB,Liu P,et al.Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia[J].Proc Natl Acad Sci USA,2008,105(12):4826-4831.
[17] Chen S,Wu S,Li W,et al.Investigation of the therapeutic effectiveness of active components in Sini decoction by acomprehensive GC/LC-MS based metabolomics and network pharmacology approaches[J].Mol Biosyst,2014,10(12):3310-3321.
[18] Tan G,Liu M,Dong X,et al.A strategy for rapid analysis of xenobiotic metabolome of Sini decoction in vivo using ultra-performance liquid chromatography-electrospray ionization quadrupole-time-of-flight mass spectrometry combined with pattern recognition approach[J].J Pharm Biomed Anal,2014,96:187-196.
[19] 李志勇,鲍红娟,张硕峰,等.四逆汤配伍环境下的附子“效-毒网络”交集调控研究[J].中国中医药杂志,2015,40(4)：733-738.
[20] 吴德坤,郑景辉,张新春,等.基于文献的四逆汤干预心肌梗死模型代谢组的生物信息学分析[J].中药新药与临床药理,2017,28(3):400-405.