[1]杨文佳,张华海,谢福恒.滋水涵木方联合多巴丝肼片治疗肝肾亏虚型帕金森病临床研究*[J].陕西中医,2019,(8):1021-1024.
　YANG Wenjia,ZHANG Huahai,XIE Fuheng..Clinical observation on cognitive function of patients with Parkinson's disease of liver and kidney deficiency by Zishui Hanmu prescription combined with dopazide tablets[J].,2019,(8):1021-1024.
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滋水涵木方联合多巴丝肼片治疗肝肾亏虚型帕金森病临床研究*
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年8期
页码:
1021-1024
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Clinical observation on cognitive function of patients with Parkinson's disease of liver and kidney deficiency by Zishui Hanmu prescription combined with dopazide tablets
文章编号:
DOI:10.3969/j.issn.1000-7369.2019.08.010
作者:
杨文佳1; 张华海2; 谢福恒3
1.陕西省杨凌示范区医院（杨凌 712100）；2.西北农林科技大学（杨凌712100）；3.陕西中医药大学（咸阳 712046 ）
Author(s):
YANG Wenjia; ZHANG Huahai; XIE Fuheng.
Shaanxi Yangling Demonstration Area Hospital （Yangling 712100）
关键词:
滋水涵木方; 多巴丝肼片; 帕金森; 认知功能; 肝肾亏虚型; 临床研究
Keywords:
Key words Zishui Hanmu prescription; Dopazide tablets; Parkinson; Cognitive function; Liver and kidney deficiency type; Clinical observation
分类号:
R259
文献标志码:
A
摘要:
摘 要 目的：观察滋水涵木方联合多巴丝肼片对肝肾亏虚型帕金森患者认知功能及血清炎性因子的影响，为临床治疗帕金森患者认知功能提供有效治疗方法。方法：将73例肝肾亏虚型帕金森患者随机分为治疗组37例与对照组36例，对照组给予多巴丝肼片口服，治疗组在对照组基础上给予滋水涵木方加减，治疗90 d，观察两组治疗前后帕金森病评定量表(UPDRS)、蒙特利尔认知评估量表(MoCA)、中医证候积分表、日常生活能力量表(ADL)、血清炎性因子IL-1β、IL-2、IL-6 、神经营养因子-3(NT-3)等。结果：①治疗组完全缓解率为29.7%，总缓解率为91.8%；对照组完全缓解率为11.1%，总缓解率为80.5%，两组在缓解率方面比较（P＜0.05）；② 两组治疗后帕金森病评定量表(UPDRS)、蒙特利尔认知评估量表( MoCA)、中医证候积分表、日常生活能力量表(ADL)对比，两组对比治疗组优于对照组（P＜0.05）；③两组治疗后IL-1β、IL-2、IL-6 、NT-3方面对比(P＜0.05)。结论：滋水涵木方联合多巴丝肼片对肝肾亏虚型帕金森患者认知功能有确切疗效。
Abstract:
Abstract Objective：To observe the effect of Zishui Hanmu prescription combined with Dopazide tablets on cognitive function and serum inflammatory factors in patients with Parkinson's disease of liver and kidney deficiency,in order to provide effective treatment for cognitive function of patients with Parkinson's disease. Methods：73 patients with Parkinson's disease of deficiency of liver and kidney were randomly divided into treatment group (37 cases) and control group (36 cases). The control group was given dopazide tablets orally. The treatment group was given Zishui Hanmu prescription on the basis of the control group for 90 days. The Parkinson's disease rating scale (UPDRS),Montreal cognitive assessment scale (MoCA),TCM syndrome integral scale and ADL were observed before and after treatment. ADL,serum inflammatory factors IL-1beta,IL-2,IL-6,neurotrophic factor-3 (NT-3) adverse reactions and so on. Results：The complete remission rate was 29.7%,total remission rate was 91.8% in the treatment group；the complete remission rate in the control group was 11.1%,total remission rate was 80.5%. The remission rates of the two groups were compared (P＜0.05). The Parkinson's disease rating scale (UPDRS),Montreal cognitive assessment scale (MoCA),TCM syndrome integral scale and days after treatment were compared between the two groups. Compared with ADL,the treatment group was better than the control group (P＜0.05). After treatment,IL-1beta,IL-2,IL-6 and NT-3 were compared between the two groups (P＜0.05). Conclusion：Zishui Hanmu decoction combined with dopazide tablets has definite effect on cognitive function of patients with Parkinson's disease of liver and kidney deficiency.

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备注/Memo

备注/Memo:
*陕西省教育厅科研课题（16JK1201）
更新日期/Last Update: 2019-08-15